Sébastien PETTON
Océanographie physique côtière / instrumentation et modélisation
Ingénieur(e) de Recherche
Ifremer
Laboratoire LEMAR – 2018
Affectation
Laboratoire LEMAR
Discovery
Contact
02 98 89 29 53
Liens
Publications dans des revues à comité de lecture répertoriées dans les bases internationales (ACL) depuis 2010
355235
ACL
petton
items
1
apa
0
default
desc
1
Petton, S.
185452
https://www-iuem.univ-brest.fr/lemar/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-c8d93face19d36db88c9cc202bdf7b23%22%2C%22meta%22%3A%7B%22request_last%22%3A50%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22YDUSCRMN%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Petton%20et%20al.%22%2C%22parsedDate%22%3A%222024-04-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Pernet%2C%20F.%2C%20Le%20Roy%2C%20V.%2C%20Huber%2C%20M.%2C%20Martin%2C%20S.%2C%20Mace%2C%20E.%2C%20Bozec%2C%20Y.%2C%20Loisel%2C%20S.%2C%20Rimmelin-Maury%2C%20P.%2C%20Grossteffan%2C%20E.%2C%20Repecaud%2C%20M.%2C%20Quemener%2C%20L.%2C%20Retho%2C%20M.%2C%20Manac%26%23x2019%3Bh%2C%20S.%2C%20Papin%2C%20M.%2C%20Pineau%2C%20P.%2C%20Lacoue-Labarthe%2C%20T.%2C%20Deborde%2C%20J.%2C%20Costes%2C%20L.%2C%20%26%23x2026%3B%20Gazeau%2C%20F.%20%282024%29.%20French%20coastal%20network%20for%20carbonate%20system%20monitoring%3A%20the%20CocoriCO%3Csub%3E2%3C%5C%2Fsub%3E%20dataset.%20%3Ci%3EEARTH%20SYSTEM%20SCIENCE%20DATA%3C%5C%2Fi%3E%2C%20%3Ci%3E16%3C%5C%2Fi%3E%284%29%2C%201667%26%23x2013%3B1688.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5194%5C%2Fessd-16-1667-2024%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5194%5C%2Fessd-16-1667-2024%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DYDUSCRMN%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22French%20coastal%20network%20for%20carbonate%20system%20monitoring%3A%20the%20CocoriCO%3Csub%3E2%3C%5C%2Fsub%3E%20dataset%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valerian%22%2C%22lastName%22%3A%22Le%20Roy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Huber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Mace%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Bozec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22Loisel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peggy%22%2C%22lastName%22%3A%22Rimmelin-Maury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Grossteffan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michel%22%2C%22lastName%22%3A%22Repecaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loic%22%2C%22lastName%22%3A%22Quemener%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Retho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soazig%22%2C%22lastName%22%3A%22Manac%27h%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathias%22%2C%22lastName%22%3A%22Papin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Pineau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Lacoue-Labarthe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Deborde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%22%2C%22lastName%22%3A%22Costes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Polsenaere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loic%22%2C%22lastName%22%3A%22Rigouin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Benhamou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Gouriou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josephine%22%2C%22lastName%22%3A%22Lequeux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Labourdette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Savoye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%22%2C%22lastName%22%3A%22Messiaen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Foucault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Ouisse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marion%22%2C%22lastName%22%3A%22Richard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franck%22%2C%22lastName%22%3A%22Lagarde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Voron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentin%22%2C%22lastName%22%3A%22Kempf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Mas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Giannecchini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Vidussi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Behzad%22%2C%22lastName%22%3A%22Mostajir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Leredde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samir%22%2C%22lastName%22%3A%22Alliouane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Gattuso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Gazeau%22%7D%5D%2C%22abstractNote%22%3A%22Since%20the%20beginning%20of%20the%20industrial%20revolution%2C%20atmospheric%20carbon%20dioxide%20%28CO2%29%20concentrations%20have%20risen%20steadily%20and%20have%20induced%20a%20decrease%20of%20the%20averaged%20surface%20ocean%20pH%20by%200.1%20units%2C%20corresponding%20to%20an%20increase%20in%20ocean%20acidity%20of%20about%2030%20%25.%20In%20addition%20to%20ocean%20warming%2C%20ocean%20acidification%20poses%20a%20tremendous%20challenge%20to%20some%20marine%20organisms%2C%20especially%20calcifiers.%20The%20need%20for%20long-term%20oceanic%20observations%20of%20pH%20and%20temperature%20is%20a%20key%20element%20to%20assess%20the%20vulnerability%20of%20marine%20communities%20and%20ecosystems%20to%20these%20pressures.%20Nearshore%20productive%20environments%2C%20where%20a%20large%20majority%20of%20shellfish%20farming%20activities%20are%20conducted%2C%20are%20known%20to%20present%20pH%20levels%20as%20well%20as%20amplitudes%20of%20daily%20and%20seasonal%20variations%20that%20are%20much%20larger%20than%20those%20observed%20in%20the%20open%20ocean.%20Yet%2C%20to%20date%2C%20there%20are%20very%20few%20coastal%20observation%20sites%20where%20these%20parameters%20are%20measured%20simultaneously%20and%20at%20high%20frequency.%20To%20bridge%20this%20gap%2C%20an%20observation%20network%20was%20initiated%20in%202021%20in%20the%20framework%20of%20the%20CocoriCO%282%29%20project.%20Six%20sites%20were%20selected%20along%20the%20French%20Atlantic%20and%20Mediterranean%20coastlines%20based%20on%20their%20importance%20in%20terms%20of%20shellfish%20production%20and%20the%20presence%20of%20high-%20and%20low-frequency%20monitoring%20activities.%20At%20each%20site%2C%20autonomous%20pH%20sensors%20were%20deployed%2C%20both%20inside%20and%20outside%20shellfish%20production%20areas%2C%20next%20to%20high-frequency%20CTD%20%28conductivity-temperature-depth%29%20probes%20operated%20through%20two%20operating%20monitoring%20networks.%20pH%20sensors%20were%20set%20to%20an%20acquisition%20rate%20of%2015%20min%2C%20and%20discrete%20seawater%20samples%20were%20collected%20biweekly%20in%20order%20to%20control%20the%20quality%20of%20pH%20data%20%28laboratory%20spectrophotometric%20measurements%29%20as%20well%20as%20to%20measure%20total%20alkalinity%20and%20dissolved%20inorganic%20carbon%20concentrations%20for%20full%20characterization%20of%20the%20carbonate%20system.%20While%20this%20network%20has%20been%20up%20and%20running%20for%20more%20than%202%20years%2C%20the%20acquired%20dataset%20has%20already%20revealed%20important%20differences%20in%20terms%20of%20pH%20variations%20between%20monitored%20sites%20related%20to%20the%20influence%20of%20diverse%20processes%20%28freshwater%20inputs%2C%20tides%2C%20temperature%2C%20biological%20processes%29.%20Data%20are%20available%20at%2010.17882%5C%2F96982%20%28Petton%20et%20al.%2C%202023a%29.%22%2C%22date%22%3A%22APR%204%202024%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.5194%5C%2Fessd-16-1667-2024%22%2C%22ISSN%22%3A%221866-3508%2C%201866-3516%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fapi%5C%2Fgateway%3FGWVersion%3D2%26SrcAuth%3DPQPLP%26SrcApp%3DWOS%26DestURL%3Dhttps%253A%252F%252Fwww.proquest.com%252Fdocview%252F3031526433%252Fembedded%252F1960DKFZYQ2U5YA1%253Fpq-origsite%253Dwos%26DestApp%3DPQP_ExternalLink%26SrcItemId%3DWOS%3A001197977400001%26SrcAppSID%3DEUW1ED0B52ubZEUL3BeMV9hOamtff%26HMAC%3DKKgLdFHHYDMMG1Ka0IUe3AW0Y3kJH5bPYr1k6AlisEs%253D%22%2C%22collections%22%3A%5B%22MXS8HMWQ%22%5D%2C%22dateModified%22%3A%222024-04-20T13%3A24%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22VP5BG24E%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Metzl%20et%20al.%22%2C%22parsedDate%22%3A%222024-01-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMetzl%2C%20N.%2C%20Fin%2C%20J.%2C%20Lo%20Monaco%2C%20C.%2C%20Mignon%2C%20C.%2C%20Alliouane%2C%20S.%2C%20Antoine%2C%20D.%2C%20Bourdin%2C%20G.%2C%20Boutin%2C%20J.%2C%20Bozec%2C%20Y.%2C%20Conan%2C%20P.%2C%20Coppola%2C%20L.%2C%20Diaz%2C%20F.%2C%20Douville%2C%20E.%2C%20de%20Madron%2C%20X.%20D.%2C%20Gattuso%2C%20J.-P.%2C%20Gazeau%2C%20F.%2C%20Golbol%2C%20M.%2C%20Lansard%2C%20B.%2C%20Lefevre%2C%20D.%2C%20%26%23x2026%3B%20Wimart-Rousseau%2C%20C.%20%282024%29.%20A%20synthesis%20of%20ocean%20total%20alkalinity%20and%20dissolved%20inorganic%20carbon%20measurements%20from%201993%20to%202022%3A%20the%20SNAPO-CO2-v1%20dataset.%20%3Ci%3EEARTH%20SYSTEM%20SCIENCE%20DATA%3C%5C%2Fi%3E%2C%20%3Ci%3E16%3C%5C%2Fi%3E%281%29%2C%2089%26%23x2013%3B120.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5194%5C%2Fessd-16-89-2024%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5194%5C%2Fessd-16-89-2024%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DVP5BG24E%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20synthesis%20of%20ocean%20total%20alkalinity%20and%20dissolved%20inorganic%20carbon%20measurements%20from%201993%20to%202022%3A%20the%20SNAPO-CO2-v1%20dataset%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Metzl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Fin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%22%2C%22lastName%22%3A%22Lo%20Monaco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claude%22%2C%22lastName%22%3A%22Mignon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samir%22%2C%22lastName%22%3A%22Alliouane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Antoine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Bourdin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Boutin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Bozec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Conan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laurent%22%2C%22lastName%22%3A%22Coppola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Diaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Douville%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%20Durrieu%22%2C%22lastName%22%3A%22de%20Madron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Pierre%22%2C%22lastName%22%3A%22Gattuso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederic%22%2C%22lastName%22%3A%22Gazeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melek%22%2C%22lastName%22%3A%22Golbol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Lansard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Lefevre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%22%2C%22lastName%22%3A%22Lefevre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Lombard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ferial%22%2C%22lastName%22%3A%22Louanchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liliane%22%2C%22lastName%22%3A%22Merlivat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Olivier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Petrenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mireille%22%2C%22lastName%22%3A%22Pujo-Pay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Rabouille%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Reverdin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Celine%22%2C%22lastName%22%3A%22Ridame%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aline%22%2C%22lastName%22%3A%22Tribollet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincenzo%22%2C%22lastName%22%3A%22Vellucci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thibaut%22%2C%22lastName%22%3A%22Wagener%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Wimart-Rousseau%22%7D%5D%2C%22abstractNote%22%3A%22Total%20alkalinity%20%28A%28T%29%29%20and%20dissolved%20inorganic%20carbon%20%28C-T%29%20in%20the%20oceans%20are%20important%20properties%20with%20respect%20to%20understanding%20the%20ocean%20carbon%20cycle%20and%20its%20link%20to%20global%20change%20%28ocean%20carbon%20sinks%20and%20sources%2C%20ocean%20acidification%29%20and%20ultimately%20finding%20carbon-based%20solutions%20or%20mitigation%20procedures%20%28marine%20carbon%20removal%29.%20We%20present%20a%20database%20of%20more%20than%2044%20400%20A%28T%29%20and%20C-T%20observations%20along%20with%20basic%20ancillary%20data%20%28spatiotemporal%20location%2C%20depth%2C%20temperature%20and%20salinity%29%20from%20various%20ocean%20regions%20obtained%2C%20mainly%20in%20the%20framework%20of%20French%20projects%2C%20since%201993.%20This%20includes%20both%20surface%20and%20water%20column%20data%20acquired%20in%20the%20open%20ocean%2C%20coastal%20zones%20and%20in%20the%20Mediterranean%20Sea%20and%20either%20from%20time%20series%20or%20dedicated%20one-off%20cruises.%20Most%20A%28T%29%20and%20C-T%20data%20in%20this%20synthesis%20were%20measured%20from%20discrete%20samples%20using%20the%20same%20closed-cell%20potentiometric%20titration%20calibrated%20with%20Certified%20Reference%20Material%2C%20with%20an%20overall%20accuracy%20of%20%2B%5C%2F-%204%20mu%20mol%20kg%28-1%29%20for%20both%20A%28T%29%20and%20C-T.%20The%20data%20are%20provided%20in%20two%20separate%20datasets%20-%20for%20the%20Global%20Ocean%20and%20the%20Mediterranean%20Sea%20%28https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.17882%5C%2F95414%2C%20Metzl%20et%20al.%2C%202023%29%2C%20respectively%20-%20that%20offer%20a%20direct%20use%20for%20regional%20or%20global%20purposes%2C%20e.g.%2C%20A%28T%29-salinity%20relationships%2C%20long-term%20C-T%20estimates%2C%20and%20constraint%20and%20validation%20of%20diagnostic%20C-T%20and%20A%28T%29%20reconstructed%20fields%20or%20ocean%20carbon%20and%20coupled%20climate-carbon%20models%20simulations%20as%20well%20as%20data%20derived%20from%20Biogeochemical-Argo%20%28BGC-Argo%29%20floats.%20When%20associated%20with%20other%20properties%2C%20these%20data%20can%20also%20be%20used%20to%20calculate%20pH%2C%20the%20fugacity%20of%20CO2%20%28fCO%282%29%29%20and%20other%20carbon%20system%20properties%20to%20derive%20ocean%20acidification%20rates%20or%20air-sea%20CO2%20fluxes.%22%2C%22date%22%3A%22JAN%209%202024%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.5194%5C%2Fessd-16-89-2024%22%2C%22ISSN%22%3A%221866-3508%2C%201866-3516%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fapi%5C%2Fgateway%3FGWVersion%3D2%26SrcAuth%3DPQPLP%26SrcApp%3DWOS%26DestURL%3Dhttps%253A%252F%252Fwww.proquest.com%252Fdocview%252F2911701338%252Fembedded%252F81S32YD9KSNIP41D%253Fpq-origsite%253Dwos%26DestApp%3DPQP_ExternalLink%26SrcItemId%3DWOS%3A001173390600001%26SrcAppSID%3DEUW1ED0E5AVGMk7Y5L95F8mCGak72%22%2C%22collections%22%3A%5B%22MXS8HMWQ%22%5D%2C%22dateModified%22%3A%222024-03-22T08%3A00%3A55Z%22%7D%7D%2C%7B%22key%22%3A%228FPHRGYF%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dantan%20et%20al.%22%2C%22parsedDate%22%3A%222024-02-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDantan%2C%20L.%2C%20Toulza%2C%20E.%2C%20Petton%2C%20B.%2C%20Montagnani%2C%20C.%2C%20Degremont%2C%20L.%2C%20Morga%2C%20B.%2C%20Fleury%2C%20Y.%2C%20Mitta%2C%20G.%2C%20Gueguen%2C%20Y.%2C%20Vidal-Dupiol%2C%20J.%2C%20%26amp%3B%20Cosseau%2C%20C.%20%282024%29.%20Microbial%20education%20for%20marine%20invertebrate%20disease%20prevention%20in%20aquaculture.%20%3Ci%3EREVIEWS%20IN%20AQUACULTURE%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fraq.12893%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fraq.12893%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D8FPHRGYF%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Microbial%20education%20for%20marine%20invertebrate%20disease%20prevention%20in%20aquaculture%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luc%22%2C%22lastName%22%3A%22Dantan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Morga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Celine%22%2C%22lastName%22%3A%22Cosseau%22%7D%5D%2C%22abstractNote%22%3A%22The%20holobiont%20theory%20expands%20the%20notion%20of%20individual%20multicellular%20organisms%20as%20a%20community%20composed%20of%20a%20host%20and%20all%20its%20associated%20microorganisms.%20This%20concept%20has%20been%20extensively%20studied%20in%20the%20field%20of%20aquaculture%2C%20where%20increasing%20evidence%20has%20highlighted%20the%20importance%20of%20the%20host%20associated%20microorganisms%20in%20species%20fitness.%20Here%2C%20we%20focus%20our%20review%20on%20mollusc%20and%20crustacean%20species%20in%20which%20microbiota%20dysbiosis%20has%20recently%20been%20described%20in%20the%20context%20of%20various%20diseases%2C%20resulting%20in%20significant%20economic%20losses.%20Influencing%20the%20holobiont%20structure%20through%20the%20use%20of%20probiotics%20is%20a%20potential%20strategy%20that%20could%20improve%20the%20fitness%20or%20the%20robustness%20of%20cultivated%20species.%20We%20discuss%20here%20the%20possibility%20of%20developing%20microbiome%20targeted%20prophylactic%20approaches%20by%20promoting%20%281%29%20methods%20to%20identify%20host%20microbial%20community%20that%20fosters%20good%20health%20status%20and%20%282%29%20early%20life%20microbial%20education%20to%20favour%20long-term%20resistance%20to%20stress%20or%20disease.%20This%20review%20aims%20to%20inform%20the%20aquaculture%20industry%20about%20potential%20strategies%20in%20rearing%20practices%20to%20mitigate%20diseases%20and%20economic%20losses.%20Microbial%20education%20during%20the%20early%20life%20stages%20enhances%20the%20robustness%20of%20cultivated%20species%20and%20favour%20a%20long%20term%20disease%20resistance.%20image%22%2C%22date%22%3A%222024%20FEB%2015%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1111%5C%2Fraq.12893%22%2C%22ISSN%22%3A%221753-5123%2C%201753-5131%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A001162791600001%22%2C%22collections%22%3A%5B%22MXS8HMWQ%22%5D%2C%22dateModified%22%3A%222024-02-29T14%3A18%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22Q3P6EC84%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gawra%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGawra%2C%20J.%2C%20Valdivieso%2C%20A.%2C%20Roux%2C%20F.%2C%20Laporte%2C%20M.%2C%20de%20Lorgeril%2C%20J.%2C%20Gueguen%2C%20Y.%2C%20Saccas%2C%20M.%2C%20Escoubas%2C%20J.-M.%2C%20Montagnani%2C%20C.%2C%20Destoumieux-Garzon%2C%20D.%2C%20Lagarde%2C%20F.%2C%20Leroy%2C%20M.%20A.%2C%20Haffner%2C%20P.%2C%20Petton%2C%20B.%2C%20Cosseau%2C%20C.%2C%20Morga%2C%20B.%2C%20Degremont%2C%20L.%2C%20Mitta%2C%20G.%2C%20Grunau%2C%20C.%2C%20%26amp%3B%20Vidal-Dupiol%2C%20J.%20%282023%29.%20Epigenetic%20variations%20are%20more%20substantial%20than%20genetic%20variations%20in%20rapid%20adaptation%20of%20oyster%20to%20Pacific%20oyster%20mortality%20syndrome.%20%3Ci%3ESCIENCE%20ADVANCES%3C%5C%2Fi%3E%2C%20%3Ci%3E9%3C%5C%2Fi%3E%2836%29%2C%20eadh8990.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.adh8990%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.adh8990%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DQ3P6EC84%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Epigenetic%20variations%20are%20more%20substantial%20than%20genetic%20variations%20in%20rapid%20adaptation%20of%20oyster%20to%20Pacific%20oyster%20mortality%20syndrome%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janan%22%2C%22lastName%22%3A%22Gawra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%22%2C%22lastName%22%3A%22Valdivieso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Laporte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Saccas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franck%22%2C%22lastName%22%3A%22Lagarde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%20A.%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Haffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Celine%22%2C%22lastName%22%3A%22Cosseau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Morga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Grunau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%5D%2C%22abstractNote%22%3A%22Disease%20emergence%20is%20accelerating%20with%20global%20changes.%20Understanding%20by%20which%20mechanisms%20host%20populations%20can%20rapidly%20adapt%20will%20be%20crucial%20for%20management%20practices.%20Pacific%20oyster%20mortality%20syndrome%20%28POMS%29%20imposes%20a%20substantial%20and%20recurrent%20selective%20pressure%20on%20oyster%20populations%2C%20and%20rapid%20adaptation%20may%20arise%20through%20genetics%20and%20epigenetics.%20In%20this%20study%2C%20we%20used%20%28epi%29genome-wide%20association%20mapping%20to%20show%20that%20oysters%20differentially%20exposed%20to%20POMS%20displayed%20genetic%20and%20epigenetic%20signatures%20of%20selection.%20Consistent%20with%20higher%20resistance%20to%20POMS%2C%20the%20genes%20targeted%20included%20many%20genes%20in%20several%20pathways%20related%20to%20immunity.%20By%20combining%20correlation%2C%20DNA%20methylation%20quantitative%20trait%20loci%2C%20and%20variance%20partitioning%2C%20we%20revealed%20that%20a%20third%20of%20phenotypic%20variation%20was%20explained%20by%20interactions%20between%20the%20genetic%20and%20epigenetic%20information%2C%20similar%20to%2014%25%20by%20the%20genome%2C%20and%20up%20to%2025%25%20by%20the%20epigenome%20alone.%20Similar%20to%20genetically%20based%20adaptation%2C%20epigenetic%20mechanisms%20notably%20governing%20immune%20responses%20can%20contribute%20substantially%20to%20the%20rapid%20adaptation%20of%20hosts%20to%20emerging%20infectious%20diseases.%22%2C%22date%22%3A%22SEP%208%202023%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1126%5C%2Fsciadv.adh8990%22%2C%22ISSN%22%3A%222375-2548%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A001129563900011%22%2C%22collections%22%3A%5B%22IMMDEEP2%22%2C%2222KMVUMD%22%5D%2C%22dateModified%22%3A%222024-01-26T12%3A13%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22639NK9EI%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Oyanedel%20et%20al.%22%2C%22parsedDate%22%3A%222023-10-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOyanedel%2C%20D.%2C%20Lagorce%2C%20A.%2C%20Bruto%2C%20M.%2C%20Haffner%2C%20P.%2C%20Morot%2C%20A.%2C%20Labreuche%2C%20Y.%2C%20Dorant%2C%20Y.%2C%20Divonne%2C%20S.%20de%20L.%20F.%2C%20Delavat%2C%20F.%2C%20Inguimbert%2C%20N.%2C%20Montagnani%2C%20C.%2C%20Morga%2C%20B.%2C%20Toulza%2C%20E.%2C%20Chaparro%2C%20C.%2C%20Escoubas%2C%20J.-M.%2C%20Gueguen%2C%20Y.%2C%20Vidal-Dupiol%2C%20J.%2C%20de%20Lorgeril%2C%20J.%2C%20Petton%2C%20B.%2C%20%26%23x2026%3B%20Destoumieux-Garzon%2C%20D.%20%282023%29.%20Cooperation%20and%20cheating%20orchestrate%20Vibrio%20assemblages%20and%20polymicrobial%20synergy%20in%20oysters%20infected%20with%20OsHV-1%20virus.%20%3Ci%3EPROCEEDINGS%20OF%20THE%20NATIONAL%20ACADEMY%20OF%20SCIENCES%20OF%20THE%20UNITED%20STATES%20OF%20AMERICA%3C%5C%2Fi%3E%2C%20%3Ci%3E120%3C%5C%2Fi%3E%2840%29%2C%20e2305195120.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2305195120%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2305195120%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D639NK9EI%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cooperation%20and%20cheating%20orchestrate%20Vibrio%20assemblages%20and%20polymicrobial%20synergy%20in%20oysters%20infected%20with%20OsHV-1%20virus%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Oyanedel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Lagorce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Bruto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Haffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amandine%22%2C%22lastName%22%3A%22Morot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Labreuche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Dorant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%20de%20La%20Forest%22%2C%22lastName%22%3A%22Divonne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois%22%2C%22lastName%22%3A%22Delavat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Inguimbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Morga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Tourbiez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea-Lou%22%2C%22lastName%22%3A%22Pimpare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oceane%22%2C%22lastName%22%3A%22Romatif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliette%22%2C%22lastName%22%3A%22Pouzadoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%20M.%22%2C%22lastName%22%3A%22Charriere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Agnes%22%2C%22lastName%22%3A%22Travers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%5D%2C%22abstractNote%22%3A%22Polymicrobial%20infections%20threaten%20the%20health%20of%20humans%20and%20animals%20but%20remain%20under-studied%20in%20natural%20systems.%20We%20recently%20described%20the%20Pacific%20Oyster%20Mortality%20Syndrome%20%28POMS%29%2C%20a%20polymicrobial%20disease%20affecting%20oyster%20production%20worldwide.%20In%20the%20French%20Atlantic%20coast%2C%20the%20disease%20involves%20coinfection%20with%20ostreid%20herpesvirus%201%20%28OsHV-1%29%20and%20virulent%20Vibrio.%20However%2C%20it%20is%20unknown%20whether%20consistent%20Vibrio%20populations%20are%20associated%20with%20POMS%20in%20different%20regions%2C%20how%20Vibrio%20contribute%20to%20POMS%2C%20and%20how%20they%20interact%20with%20OsHV-%201%20during%20pathogenesis.%20By%20connecting%20field%20-based%20approaches%20in%20a%20Mediterranean%20ecosystem%2C%20laboratory%20infection%20assays%20and%20functional%20genomics%2C%20we%20uncovered%20a%20web%20of%20interdependencies%20that%20shape%20the%20structure%20and%20function%20of%20the%20POMS%20pathobiota.%20We%20show%20that%20Vibrio%20harveyi%20and%20Vibrio%20rotiferianus%20are%20predomi-nant%20in%20OsHV-1-%20diseased%20oysters%20and%20that%20OsHV-1%20drives%20the%20partition%20of%20the%20Vibrio%20community%20observed%20in%20the%20field.%20However%20only%20V.%20harveyi%20synergizes%20with%20OsHV-1%20by%20promoting%20mutual%20growth%20and%20accelerating%20oyster%20death.%20V.%20harveyi%20shows%20high-%20virulence%20potential%20and%20dampens%20oyster%20cellular%20defenses%20through%20a%20type%203%20secretion%20system%2C%20mak-ing%20oysters%20a%20more%20favorable%20niche%20for%20microbe%20colonization.%20In%20addition%2C%20V.%20harveyi%20produces%20a%20key%20siderophore%20called%20vibrioferrin.%20This%20important%20resource%20promotes%20the%20growth%20of%20V.%20rotiferianus%2C%20which%20cooccurs%20with%20V.%20harveyi%20in%20diseased%20oysters%2C%20and%20behaves%20as%20a%20cheater%20by%20benefiting%20from%20V.%20harveyi%20metabolite%20sharing.%20Our%20data%20show%20that%20cooperative%20behaviors%20contribute%20to%20synergy%20between%20bacterial%20and%20viral%20coinfecting%20partners.%20Additional%20cheating%20behaviors%20further%20shape%20the%20polymicrobial%20consortium.%20Controlling%20cooperative%20behaviors%20or%20countering%20their%20effects%20opens%20avenues%20for%20miti-gating%20polymicrobial%20diseases.%22%2C%22date%22%3A%22OCT%203%202023%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.2305195120%22%2C%22ISSN%22%3A%220027-8424%2C%201091-6490%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A001088032800002%22%2C%22collections%22%3A%5B%22IMMDEEP2%22%2C%2222KMVUMD%22%5D%2C%22dateModified%22%3A%222023-11-12T06%3A35%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22ZCY4LVKR%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dupoue%20et%20al.%22%2C%22parsedDate%22%3A%222023-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDupoue%2C%20A.%2C%20Mello%2C%20D.%20F.%2C%20Trevisan%2C%20R.%2C%20Dubreuil%2C%20C.%2C%20Queau%2C%20I.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Huvet%2C%20A.%2C%20Guevel%2C%20B.%2C%20Com%2C%20E.%2C%20Pernet%2C%20F.%2C%20Salin%2C%20K.%2C%20Fleury%2C%20E.%2C%20%26amp%3B%20Corporeau%2C%20C.%20%282023%29.%20Intertidal%20limits%20shape%20covariation%20between%20metabolic%20plasticity%2C%20oxidative%20stress%20and%20telomere%20dynamics%20in%20Pacific%20oyster%3Ci%3E%20%28Crassostrea%3C%5C%2Fi%3E%3Ci%3E%20gigas%29%3C%5C%2Fi%3E.%20%3Ci%3EMARINE%20ENVIRONMENTAL%20RESEARCH%3C%5C%2Fi%3E%2C%20%3Ci%3E191%3C%5C%2Fi%3E%2C%20106149.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.marenvres.2023.106149%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.marenvres.2023.106149%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DZCY4LVKR%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intertidal%20limits%20shape%20covariation%20between%20metabolic%20plasticity%2C%20oxidative%20stress%20and%20telomere%20dynamics%20in%20Pacific%20oyster%3Ci%3E%20%28Crassostrea%3C%5C%2Fi%3E%3Ci%3E%20gigas%29%3C%5C%2Fi%3E%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreaz%22%2C%22lastName%22%3A%22Dupoue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Danielle%20Ferraz%22%2C%22lastName%22%3A%22Mello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Trevisan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Dubreuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Queau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Huvet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Blandine%22%2C%22lastName%22%3A%22Guevel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%22%2C%22lastName%22%3A%22Com%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karine%22%2C%22lastName%22%3A%22Salin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Corporeau%22%7D%5D%2C%22abstractNote%22%3A%22In%20intertidal%20zones%2C%20species%20such%20as%20sessile%20shellfish%20exhibit%20extended%20phenotypic%20plasticity%20to%20face%20rapid%20environmental%20changes%2C%20but%20whether%20frequent%20exposure%20to%20intertidal%20limits%20of%20the%20distribution%20range%20impose%20physiological%20costs%20for%20the%20animal%20remains%20elusive.%20Here%2C%20we%20explored%20how%20phenotypic%20plasticity%20varied%20along%20foreshore%20range%20at%20multiple%20organization%20levels%2C%20from%20molecular%20to%20cellular%20and%20whole%20organism%20acclimatization%2C%20in%20the%20Pacific%20oyster%20%28Crassostrea%20gigas%29.%20We%20exposed%207-month-old%20individuals%20for%20up%20to%2016%20months%20to%20three%20foreshore%20levels%20covering%20the%20vertical%20range%20for%20this%20species%2C%20representing%2020%2C%2050%20and%2080%25%20of%20the%20time%20spent%20submerged%20monthly.%20Individuals%20at%20the%20upper%20range%20limit%20produced%20energy%20more%20efficiently%2C%20as%20seen%20by%20steeper%20metabolic%20reactive%20norms%20and%20unaltered%20ATP%20levels%20despite%20reduced%20mitochondrial%20density.%20By%20spending%20most%20of%20their%20time%20emerged%2C%20oysters%20mounted%20an%20antioxidant%20shielding%20concomitant%20with%20lower%20levels%20of%20pro-oxidant%20proteins%20and%20postponed%20age-related%20telomere%20attrition.%20Instead%2C%20individuals%20exposed%20at%20the%20lower%20limit%20range%20near%20subtidal%20conditions%20showed%20lower%20energy%20efficiencies%2C%20greater%20oxidative%20stress%20and%20shorter%20telomere%20length.%20These%20results%20unraveled%20the%20extended%20acclimatization%20strategies%20and%20the%20physiological%20costs%20of%20living%20too%20fast%20in%20subtidal%20conditions%20for%20an%20intertidal%20species.%22%2C%22date%22%3A%22OCT%202023%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.marenvres.2023.106149%22%2C%22ISSN%22%3A%220141-1136%2C%201879-0291%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A001072189400001%22%2C%22collections%22%3A%5B%22IMMDEEP2%22%5D%2C%22dateModified%22%3A%222023-10-21T10%3A14%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22LLNUYGC8%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Piel%20et%20al.%22%2C%22parsedDate%22%3A%222022-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPiel%2C%20D.%2C%20Bruto%2C%20M.%2C%20Labreuche%2C%20Y.%2C%20Blanquart%2C%20F.%2C%20Goudenege%2C%20D.%2C%20Barcia-Cruz%2C%20R.%2C%20Chenivesse%2C%20S.%2C%20Le%20Panse%2C%20S.%2C%20James%2C%20A.%2C%20Dubert%2C%20J.%2C%20Petton%2C%20B.%2C%20Lieberman%2C%20E.%2C%20Wegner%2C%20K.%20M.%2C%20Hussain%2C%20F.%20A.%2C%20Kauffman%2C%20K.%20M.%2C%20Polz%2C%20M.%20F.%2C%20Bikard%2C%20D.%2C%20Gandon%2C%20S.%2C%20Rocha%2C%20E.%20P.%20C.%2C%20%26amp%3B%20Le%20Roux%2C%20F.%20%282022%29.%20Phage-host%20coevolution%20in%20natural%20populations.%20%3Ci%3ENature%20Microbiology%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%287%29%2C%201075-%2B.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41564-022-01157-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41564-022-01157-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DLLNUYGC8%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Phage-host%20coevolution%20in%20natural%20populations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Piel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Bruto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Labreuche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois%22%2C%22lastName%22%3A%22Blanquart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Goudenege%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruben%22%2C%22lastName%22%3A%22Barcia-Cruz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Chenivesse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Le%20Panse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adele%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%22%2C%22lastName%22%3A%22Dubert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erica%22%2C%22lastName%22%3A%22Lieberman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20Mathias%22%2C%22lastName%22%3A%22Wegner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fatima%20A.%22%2C%22lastName%22%3A%22Hussain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%20M.%22%2C%22lastName%22%3A%22Kauffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20F.%22%2C%22lastName%22%3A%22Polz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Bikard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Gandon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%20P.%20C.%22%2C%22lastName%22%3A%22Rocha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%5D%2C%22abstractNote%22%3A%22Coevolution%20between%20bacteriophages%20%28phages%29%20and%20their%20bacterial%20hosts%20occurs%20through%20changes%20in%20resistance%20and%20counter-resistance%20mechanisms.%20To%20assess%20phage-host%20evolution%20in%20wild%20populations%2C%20we%20isolated%20195%20Vibrio%20crassostreae%20strains%20and%20243%20vibriophages%20during%20a%205-month%20time%20series%20from%20an%20oyster%20farm%20and%20combined%20these%20isolates%20with%20existing%20V.%20crassostreae%20and%20phage%20isolates.%20Cross-infection%20studies%20of%2081%2C926%20host-phage%20pairs%20delineated%20a%20modular%20network%20where%20phages%20are%20best%20at%20infecting%20co-occurring%20hosts%2C%20indicating%20local%20adaptation.%20Successful%20propagation%20of%20phage%20is%20restricted%20by%20the%20ability%20to%20adsorb%20to%20closely%20related%20bacteria%20and%20further%20constrained%20by%20strain-specific%20defence%20systems.%20These%20defences%20are%20highly%20diverse%20and%20predominantly%20located%20on%20mobile%20genetic%20elements%2C%20and%20multiple%20defences%20are%20active%20within%20a%20single%20genome.%20We%20further%20show%20that%20epigenetic%20and%20genomic%20modifications%20enable%20phage%20to%20adapt%20to%20bacterial%20defences%20and%20alter%20host%20range.%20Our%20findings%20reveal%20that%20the%20evolution%20of%20bacterial%20defences%20and%20phage%20counter-defences%20is%20underpinned%20by%20frequent%20genetic%20exchanges%20with%2C%20and%20between%2C%20mobile%20genetic%20elements.%20Analysis%20of%20a%20large%20set%20of%20marine%20vibrios%20and%20their%20phages%20identifies%20mechanisms%20of%20phage-host%20coevolution.%22%2C%22date%22%3A%22JUL%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41564-022-01157-1%22%2C%22ISSN%22%3A%222058-5276%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A000817028500005%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%2222KMVUMD%22%5D%2C%22dateModified%22%3A%222023-06-12T08%3A53%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22ZL4PREEP%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guillou%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGuillou%2C%20N.%2C%20Chapalain%2C%20G.%2C%20%26amp%3B%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%20%282023%29.%20Predicting%20sea%20surface%20salinity%20in%20a%20tidal%20estuary%20with%20machine%20learning.%20%3Ci%3EOceanologia%3C%5C%2Fi%3E%2C%20%3Ci%3E65%3C%5C%2Fi%3E%282%29%2C%20318%26%23x2013%3B332.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.oceano.2022.07.007%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.oceano.2022.07.007%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DZL4PREEP%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Predicting%20sea%20surface%20salinity%20in%20a%20tidal%20estuary%20with%20machine%20learning%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Guillou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georges%22%2C%22lastName%22%3A%22Chapalain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Petton%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2204%5C%2F2023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.oceano.2022.07.007%22%2C%22ISSN%22%3A%2200783234%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0078323422000835%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22IMMDEEP2%22%5D%2C%22dateModified%22%3A%222023-06-01T12%3A47%3A16Z%22%7D%7D%2C%7B%22key%22%3A%228ENAJ5V5%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Clerissi%20et%20al.%22%2C%22parsedDate%22%3A%222023-05-03%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EClerissi%2C%20C.%2C%20Luo%2C%20X.%2C%20Lucasson%2C%20A.%2C%20Mortaza%2C%20S.%2C%20De%20Lorgeril%2C%20J.%2C%20Toulza%2C%20E.%2C%20Petton%2C%20B.%2C%20Escoubas%2C%20J.-M.%2C%20D%26%23xE9%3Bgremont%2C%20L.%2C%20Gueguen%2C%20Y.%2C%20Destoumieux-Garz%26%23x3CC%3Bn%2C%20D.%2C%20Jacq%2C%20A.%2C%20%26amp%3B%20Mitta%2C%20G.%20%282023%29.%20A%20core%20of%20functional%20complementary%20bacteria%20infects%20oysters%20in%20Pacific%20Oyster%20Mortality%20Syndrome.%20%3Ci%3EAnimal%20Microbiome%3C%5C%2Fi%3E%2C%20%3Ci%3E5%3C%5C%2Fi%3E%281%29%2C%2026.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs42523-023-00246-8%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs42523-023-00246-8%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D8ENAJ5V5%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20core%20of%20functional%20complementary%20bacteria%20infects%20oysters%20in%20Pacific%20Oyster%20Mortality%20Syndrome%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Clerissi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xing%22%2C%22lastName%22%3A%22Luo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aude%22%2C%22lastName%22%3A%22Lucasson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shogofa%22%2C%22lastName%22%3A%22Mortaza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22De%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22D%5Cu00e9gremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garz%5Cu03ccn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annick%22%2C%22lastName%22%3A%22Jacq%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20Pacific%20oyster%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Crassostrea%20gigas%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20is%20one%20of%20the%20main%20cultivated%20invertebrate%20species%20worldwide.%20Since%202008%2C%20oyster%20juveniles%20have%20been%20confronted%20with%20a%20lethal%20syndrome%20known%20as%20the%20Pacific%20Oyster%20Mortality%20Syndrome%20%28POMS%29.%20POMS%20is%20a%20polymicrobial%20disease%20initiated%20by%20a%20primary%20infection%20with%20the%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20herpesvirus%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20OsHV-1%20%5Cu00b5Var%20that%20creates%20an%20oyster%20immunocompromised%20state%20and%20evolves%20towards%20a%20secondary%20fatal%20bacteremia.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20present%20article%2C%20we%20describe%20the%20implementation%20of%20an%20unprecedented%20combination%20of%20metabarcoding%20and%20metatranscriptomic%20approaches%20to%20show%20that%20the%20sequence%20of%20events%20in%20POMS%20pathogenesis%20is%20conserved%20across%20infectious%20environments.%20We%20also%20identified%20a%20core%20bacterial%20consortium%20which%2C%20together%20with%20OsHV-1%20%5Cu00b5Var%2C%20forms%20the%20POMS%20pathobiota.%20This%20bacterial%20consortium%20is%20characterized%20by%20high%20transcriptional%20activities%20and%20complementary%20metabolic%20functions%20to%20exploit%20host%5Cu2019s%20resources.%20A%20significant%20metabolic%20specificity%20was%20highlighted%20at%20the%20bacterial%20genus%20level%2C%20suggesting%20low%20competition%20for%20nutrients%20between%20members%20of%20the%20core%20bacteria.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Lack%20of%20metabolic%20competition%20between%20the%20core%20bacteria%20might%20favor%20complementary%20colonization%20of%20host%20tissues%20and%20contribute%20to%20the%20conservation%20of%20the%20POMS%20pathobiota%20across%20distinct%20infectious%20environments.%22%2C%22date%22%3A%222023-05-03%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs42523-023-00246-8%22%2C%22ISSN%22%3A%222524-4671%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fanimalmicrobiome.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs42523-023-00246-8%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22IMMDEEP2%22%5D%2C%22dateModified%22%3A%222023-05-26T11%3A06%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22UDJ6RMEN%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lemonnier%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELemonnier%2C%20C.%2C%20Chalopin%2C%20M.%2C%20Huvet%2C%20A.%2C%20Le%20Roux%2C%20F.%2C%20Labreuche%2C%20Y.%2C%20Petton%2C%20B.%2C%20Maignien%2C%20L.%2C%20Paul-Pont%2C%20I.%2C%20%26amp%3B%20Reveillaud%2C%20J.%20%282022%29.%20Time-series%20incubations%20in%20a%20coastal%20environment%20illuminates%20the%20importance%20of%20early%20colonizers%20and%20the%20complexity%20of%20bacterial%20biofilm%20dynamics%20on%20marine%20plastics.%20%3Ci%3EEnvironmental%20Pollution%3C%5C%2Fi%3E%2C%20%3Ci%3E312%3C%5C%2Fi%3E%2C%20119994.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.envpol.2022.119994%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.envpol.2022.119994%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DUDJ6RMEN%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Time-series%20incubations%20in%20a%20coastal%20environment%20illuminates%20the%20importance%20of%20early%20colonizers%20and%20the%20complexity%20of%20bacterial%20biofilm%20dynamics%20on%20marine%20plastics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lemonnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Chalopin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Huvet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Labreuche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Maignien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Paul-Pont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Reveillaud%22%7D%5D%2C%22abstractNote%22%3A%22The%20problematic%20of%20microplastics%20pollution%20in%20the%20marine%20environment%20is%20tightly%20linked%20to%20their%20colonization%20by%20a%20wide%20diversity%20of%20microorganisms%2C%20the%20so-called%20plastisphere.%20The%20composition%20of%20the%20plastisphere%20relies%20on%20a%20complex%20combination%20of%20multiple%20factors%20including%20the%20surrounding%20environment%2C%20the%20time%20of%20incuba-tion%20along%20with%20the%20polymer%20type%2C%20making%20it%20difficult%20to%20understand%20how%20the%20biofilm%20evolves%20during%20the%20microplastic%20lifetime%20over%20the%20oceans.%20To%20better%20define%20bacterial%20community%20assembly%20processes%20on%20plastics%2C%20we%20performed%20a%205%20months%20spatio-temporal%20survey%20of%20the%20plastisphere%20in%20an%20oyster%20farming%20area%20in%20the%20Bay%20of%20Brest%20%28France%29.%20We%20deployed%20three%20types%20of%20plastic%20pellets%20in%20two%20positions%20in%20the%20foreshore%20and%20in%20the%20water%20column.%20Plastic-associated%20biofilm%20composition%20in%20all%20these%20conditions%20was%20monitored%20using%2016%20S%20rRNA%20metabarcoding%20and%20compared%20to%20free-living%20and%20attached%20bacterial%20members%20of%20seawater.%20We%20observed%20that%20bacterial%20families%20associated%20to%20plastic%20pellets%20were%20significantly%20distinct%20from%20the%20ones%20found%20in%20seawater%2C%20with%20a%20significant%20prevalence%20of%20filamentous%20Cyanobacteria%20on%20plastics.%20No%20convergence%20towards%20a%20unique%20plastisphere%20was%20detected%20between%20polymers%20exposed%20in%20the%20intertidal%20and%20subtidal%20area%2C%20emphasizing%20the%20central%20role%20of%20the%20surrounding%20envi-ronment%20on%20constantly%20shaping%20the%20plastisphere%20community%20diversity.%20However%2C%20we%20could%20define%20a%20bulk%20of%20early-colonizers%20of%20marine%20biofilms%20such%20as%20Alteromonas%2C%20Pseudoalteromonas%20or%20Vibrio.%20These%20early-colonizers%20could%20reach%20high%20abundances%20in%20floating%20microplastics%20collected%20in%20field-sampling%20studies%2C%20suggesting%20the%20plastic%20-associated%20biofilms%20could%20remain%20at%20early%20development%20stages%20across%20large%20oceanic%20scales.%20Our%20study%20raises%20the%20hypothesis%20that%20most%20members%20of%20the%20plastisphere%2C%20including%20putative%20pathogens%2C%20could%20result%20of%20opportunistic%20colonization%20processes%20and%20unlikely%20long-term%20transport.%22%2C%22date%22%3A%22NOV%201%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.envpol.2022.119994%22%2C%22ISSN%22%3A%220269-7491%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A000864603800006%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%227BD5VS8S%22%5D%2C%22dateModified%22%3A%222023-04-28T10%3A33%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22RGWT5FNZ%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fallet%20et%20al.%22%2C%22parsedDate%22%3A%222022-06-04%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFallet%2C%20M.%2C%20Montagnani%2C%20C.%2C%20Petton%2C%20B.%2C%20Dantan%2C%20L.%2C%20de%20Lorgeril%2C%20J.%2C%20Comarmond%2C%20S.%2C%20Chaparro%2C%20C.%2C%20Toulza%2C%20E.%2C%20Boitard%2C%20S.%2C%20Escoubas%2C%20J.-M.%2C%20Vergnes%2C%20A.%2C%20Le%20Grand%2C%20J.%2C%20Bulla%2C%20I.%2C%20Gueguen%2C%20Y.%2C%20Vidal-Dupiol%2C%20J.%2C%20Grunau%2C%20C.%2C%20Mitta%2C%20G.%2C%20%26amp%3B%20Cosseau%2C%20C.%20%282022%29.%20Early%20life%20microbial%20exposures%20shape%20the%20Crassostrea%20gigas%20immune%20system%20for%20lifelong%20and%20intergenerational%20disease%20protection.%20%3Ci%3EMicrobiome%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%281%29%2C%2085.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40168-022-01280-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs40168-022-01280-5%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DRGWT5FNZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Early%20life%20microbial%20exposures%20shape%20the%20Crassostrea%20gigas%20immune%20system%20for%20lifelong%20and%20intergenerational%20disease%20protection%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manon%22%2C%22lastName%22%3A%22Fallet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luc%22%2C%22lastName%22%3A%22Dantan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Comarmond%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Boitard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%22%2C%22lastName%22%3A%22Vergnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Le%20Grand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ingo%22%2C%22lastName%22%3A%22Bulla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Grunau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Celine%22%2C%22lastName%22%3A%22Cosseau%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20The%20interaction%20of%20organisms%20with%20their%20surrounding%20microbial%20communities%20influences%20many%20biological%20processes%2C%20a%20notable%20example%20of%20which%20is%20the%20shaping%20of%20the%20immune%20system%20in%20early%20life.%20In%20the%20Pacific%20oyster%2C%20Crassostrea%20gigas%2C%20the%20role%20of%20the%20environmental%20microbial%20community%20on%20immune%20system%20maturation%20-%20and%2C%20importantly%2C%20protection%20from%20infectious%20disease%20-%20is%20still%20an%20open%20question.%20Results%3A%20Here%2C%20we%20demonstrate%20that%20early%20life%20microbial%20exposure%20durably%20improves%20oyster%20survival%20when%20challenged%20with%20the%20pathogen%20causing%20Pacific%20oyster%20mortality%20syndrome%20%28POMS%29%2C%20both%20in%20the%20exposed%20generation%20and%20in%20the%20subsequent%20one.%20Combining%20microbiota%2C%20transcriptomic%2C%20genetic%2C%20and%20epigenetic%20analyses%2C%20we%20show%20that%20the%20microbial%20exposure%20induced%20changes%20in%20epigenetic%20marks%20and%20a%20reprogramming%20of%20immune%20gene%20expression%20leading%20to%20long-term%20and%20intergenerational%20immune%20protection%20against%20POMS.%20Conclusions%3A%20We%20anticipate%20that%20this%20protection%20likely%20extends%20to%20additional%20pathogens%20and%20may%20prove%20to%20be%20an%20important%20new%20strategy%20for%20safeguarding%20oyster%20aquaculture%20efforts%20from%20infectious%20disease.%20tag%20the%20videobyte%5C%2Fvideoabstract%20in%20this%20section%22%2C%22date%22%3A%22JUN%204%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1186%5C%2Fs40168-022-01280-5%22%2C%22ISSN%22%3A%222049-2618%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A000805942700001%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%5D%2C%22dateModified%22%3A%222023-04-28T09%3A47%3A53Z%22%7D%7D%2C%7B%22key%22%3A%228TDUYDXD%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Petton%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPetton%2C%20B.%2C%20Alunno-Bruscia%2C%20M.%2C%20Mitta%2C%20G.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282023%29.%20Increased%20growth%20metabolism%20promotes%20viral%20infection%20in%20a%20susceptible%20oyster%20population.%20%3Ci%3EAquaculture%20Environment%20Interactions%3C%5C%2Fi%3E%2C%20%3Ci%3E15%3C%5C%2Fi%3E%2C%2019%26%23x2013%3B33.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Faei00450%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Faei00450%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D8TDUYDXD%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Increased%20growth%20metabolism%20promotes%20viral%20infection%20in%20a%20susceptible%20oyster%20population%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Alunno-Bruscia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22The%20magnitude%20of%20an%20epidemic%20depends%20on%20host%20susceptibility%20to%20the%20disease%2C%20a%20trait%20influenced%20by%20the%20genetic%20constitution%20of%20the%20host%20and%20its%20environment.%20While%20the%20genetic%20basis%20of%20disease%20susceptibility%20is%20often%20associated%20with%20immune%20capacities%2C%20environmental%20effects%20generally%20reflect%20complex%20physiological%20trade-offs.%20We%20suggest%20here%20that%20in%20the%20case%20of%20obligate%20pathogens%20whose%20proliferation%20depends%20on%20the%20cellular%20machinery%20of%20the%20host%20%28e.g.%20viruses%29%2C%20disease%20susceptibility%20is%20directly%20influenced%20by%20host%20growth.%20To%20test%20our%20hypothesis%2C%20we%20focussed%20on%20a%20viral%20disease%20affecting%20an%20ecologically%20relevant%20model%20exploited%20worldwide%2C%20the%20Pacific%20oyster%20Crassostrea%20gigas.%20Oysters%20originating%20from%203%20lines%20with%20contrasting%20resistance%20to%20the%20disease%20were%20divided%20into%203%20groups%20displaying%20different%20growth%20rates%20and%20acclimated%20to%203%20food%20levels%20and%202%20temperatures%20to%20generate%20different%20growth%20rates.%20These%20oysters%20were%20then%20exposed%20to%20the%20virus%2C%20and%20survival%20and%20viral%20shedding%20were%20measured.%20Finally%2C%20we%20developed%20a%20risk%20model%20to%20rank%20the%20relative%20importance%20of%20temperature%2C%20food%2C%20genetic%20selection%20and%20growth%20on%20disease-induced%20mortality.%20We%20found%20that%20increasing%20growth%20through%20temperature%2C%20food%20level%20or%20selection%20of%20fast-growing%20animals%20all%20increased%20mortality%2C%20especially%20in%20host%20populations%20where%20susceptible%20phenotypes%20dominated.%20Food%20provisioning%20was%20the%20most%20influential%20factor%20associated%20with%20higher%20viral%20shedding%2C%20followed%20by%20temperature%2C%20resistance%20phenotype%20and%20growth%20rate.%20We%20suggest%20that%20growth-forcing%20factors%20may%20promote%20the%20development%20of%20obligate%20intracellular%20pathogens%20and%20epidemic%20risk%2C%20thus%20opening%20up%20avenues%20for%20disease%20management%20based%20on%20the%20manipulation%20of%20host%20metabolism.%22%2C%22date%22%3A%22FEB%202%202023%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3354%5C%2Faei00450%22%2C%22ISSN%22%3A%221869-215X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A000946607700001%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22IMMDEEP2%22%5D%2C%22dateModified%22%3A%222023-04-03T13%3A27%3A46Z%22%7D%7D%2C%7B%22key%22%3A%227QN9LCXA%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bruyere%20et%20al.%22%2C%22parsedDate%22%3A%222022-12-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBruyere%2C%20O.%2C%20Soulard%2C%20B.%2C%20Lemonnier%2C%20H.%2C%20Laugier%2C%20T.%2C%20Hubert%2C%20M.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Desclaux%2C%20T.%2C%20Van%20Wynsberge%2C%20S.%2C%20Le%20Tesson%2C%20E.%2C%20Lefevre%2C%20J.%2C%20Dumas%2C%20F.%2C%20Kayara%2C%20J.-F.%2C%20Bourassin%2C%20E.%2C%20Lalau%2C%20N.%2C%20Antypas%2C%20F.%2C%20%26amp%3B%20Le%20Gendre%2C%20R.%20%282022%29.%20Hydrodynamic%20and%20hydrological%20processes%20within%20a%20variety%20of%20coral%20reeflagoons%3A%20field%20observations%20during%20six%20cyclonic%20seasons%20in%20New%20Caledonia.%20%3Ci%3EEarth%20System%20Science%20Data%3C%5C%2Fi%3E%2C%20%3Ci%3E14%3C%5C%2Fi%3E%2812%29%2C%205439%26%23x2013%3B5462.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5194%5C%2Fessd-14-5439-2022%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5194%5C%2Fessd-14-5439-2022%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D7QN9LCXA%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hydrodynamic%20and%20hydrological%20processes%20within%20a%20variety%20of%20coral%20reeflagoons%3A%20field%20observations%20during%20six%20cyclonic%20seasons%20in%20New%20Caledonia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oriane%22%2C%22lastName%22%3A%22Bruyere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Soulard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugues%22%2C%22lastName%22%3A%22Lemonnier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Laugier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morgane%22%2C%22lastName%22%3A%22Hubert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Terence%22%2C%22lastName%22%3A%22Desclaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Van%20Wynsberge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Le%20Tesson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22Lefevre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franck%22%2C%22lastName%22%3A%22Dumas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Francois%22%2C%22lastName%22%3A%22Kayara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuel%22%2C%22lastName%22%3A%22Bourassin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noemie%22%2C%22lastName%22%3A%22Lalau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Antypas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Le%20Gendre%22%7D%5D%2C%22abstractNote%22%3A%22From%202014%20to%202021%20during%20the%20cyclone%20seasons%2C%20extensive%20monitoring%20of%20the%20hydrodynamics%20within%20a%20variety%20of%20lagoons%20of%20New%20Caledonia%20was%20conducted%20as%20a%20part%20of%20the%20PRESENCE%20project%20%28PRESsures%20on%20coral%20Ecosystems%20of%20New%20CalEdonia%29.%20The%20PRESENCE%20project%20is%20aimed%20at%20building%20an%20efficient%20representation%20of%20the%20land-lagoon-ocean%20continuum%20at%20Grande%20Terre%2C%20New%20Caledonia%27s%20main%20island.%20Overall%2C%20coastal%20physical%20observations%20encompassed%20five%20different%20lagoons%20%28four%20of%20which%20were%20never%20before%20monitored%29%20and%20at%20least%20eight%20major%20atmospheric%20events%20ranging%20from%20tropical%20depressions%20to%20category%204%20cyclones.%20The%20main%20objectives%20of%20this%20study%20were%20to%20characterize%20the%20processes%20controlling%20the%20hydrodynamics%20and%20hydrology%20of%20these%20lagoons%20%28e.g.%2C%20ocean-lagoon%20exchanges%2C%20circulation%2C%20level%20dynamics%2C%20temperature%2C%20and%20salinity%20variability%29%2C%20and%20to%20capture%20the%20magnitude%20of%20change%20during%20extreme%20events.%20An%20additional%20objective%20was%20to%20compile%20an%20adequate%20data%20set%20for%20future%20use%20in%20high-resolution%20hydrodynamic%20models.%20Autonomous%20oceanographic%20instruments%20were%20moored%20at%20strategic%20locations%20to%20collect%20time%20series%20of%20temperature%2C%20salinity%2C%20pressure%2C%20and%20Eulerian%20currents.%20Additionally%2C%20Lagrangian%20surface%20currents%20were%20observed%20through%20deploying%20drifter%20buoys%2C%20and%20cross-shore%20hydrological%20profile%20radials%20were%20carried%20out%20using%20CTDs%20%28conductivity%2C%20temperature%2C%20depth%29.%20In%20total%2C%20five%20survey%20campaigns%20were%20conducted%2C%20beginning%20with%20the%20SPHYNX%20campaign%20which%20lasted%2015%20months%20%28December%202014%20to%20February%202016%29%20in%20the%20Hienghene-Touho%20lagoon%20and%20ended%20with%20the%209%20months%20NEMO%20campaign%20%28September%202020%20to%20April%202021%29%20in%20Moindou%20lagoon.%20Between%20these%20were%20the%205%20months%20NOUMEA%20campaign%20%28December%202016%20to%20April%202017%29%20in%20Noumea%20lagoon%2C%20the%206%20months%20ELADE%20campaign%20%28February%20to%20August%202018%29%20in%20the%20Poe%20lagoon%2C%20and%20the%205%20months%20CADHYAK%20campaign%20%28December%202019%20to%20May%202020%29%20in%20Koumac%20lagoon.%20In%20addition%20to%20characterizing%20these%20lagoons%2C%20the%20data%20set%20identifies%20important%20features%20and%20processes%2C%20such%20as%20the%20presence%20of%20internal%20waves%20on%20forereefs%2C%20wave-driven%20fluxes%20over%20reef%20barriers%2C%20and%20exchanges%20through%20passes.%20Signatures%20from%20strong%20events%20were%20also%20identified%2C%20including%20surges%2C%20thermal%20drops%20inside%20lagoons%2C%20and%20massive%20flash%20flood%20plume%20dispersion.%20Raw%20data%20sets%20were%20processed%2C%20controlled%20for%20quality%2C%20validated%2C%20and%20analyzed.%20Processed%20files%20are%20made%20publicly%20available%20in%20dedicated%20repositories%20on%20the%20SEANOE%20marine%20data%20platform%20in%20NetCDF%20format.%20Links%20%28DOI%29%20of%20individual%20data%20sets%20are%20provided%20herein.%22%2C%22date%22%3A%22DEC%2015%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.5194%5C%2Fessd-14-5439-2022%22%2C%22ISSN%22%3A%221866-3508%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A000899247500001%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%2222KMVUMD%22%5D%2C%22dateModified%22%3A%222023-01-26T08%3A31%3A51Z%22%7D%7D%2C%7B%22key%22%3A%224DHWBYDK%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nicolas%20et%20al.%22%2C%22parsedDate%22%3A%222022-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENicolas%2C%20N.%20D.%20S.%2C%20Asokan%2C%20A.%2C%20Rosa%2C%20R.%20D.%2C%20Voisin%2C%20S.%20N.%2C%20Travers%2C%20M.-A.%2C%20Rocha%2C%20G.%2C%20Dantan%2C%20L.%2C%20Dorant%2C%20Y.%2C%20Mitta%2C%20G.%2C%20Petton%2C%20B.%2C%20Charriere%2C%20G.%20M.%2C%20Escoubas%2C%20J.-M.%2C%20Boulo%2C%20V.%2C%20Pouzadoux%2C%20J.%2C%20Meudal%2C%20H.%2C%20Loth%2C%20K.%2C%20Aucagne%2C%20V.%2C%20Delmas%2C%20A.%20F.%2C%20Bulet%2C%20P.%2C%20%26%23x2026%3B%20Destoumieux-Garzon%2C%20D.%20%282022%29.%20Functional%20Diversification%20of%20Oyster%20Big%20Defensins%20Generates%20Antimicrobial%20Specificity%20and%20Synergy%20against%20Members%20of%20the%20Microbiota.%20%3Ci%3EMarine%20Drugs%3C%5C%2Fi%3E%2C%20%3Ci%3E20%3C%5C%2Fi%3E%2812%29%2C%20745.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmd20120745%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmd20120745%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D4DHWBYDK%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Functional%20Diversification%20of%20Oyster%20Big%20Defensins%20Generates%20Antimicrobial%20Specificity%20and%20Synergy%20against%20Members%20of%20the%20Microbiota%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noemie%20De%20San%22%2C%22lastName%22%3A%22Nicolas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aromal%22%2C%22lastName%22%3A%22Asokan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%20D.%22%2C%22lastName%22%3A%22Rosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%20N.%22%2C%22lastName%22%3A%22Voisin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Agnes%22%2C%22lastName%22%3A%22Travers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gustavo%22%2C%22lastName%22%3A%22Rocha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luc%22%2C%22lastName%22%3A%22Dantan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Dorant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%20M.%22%2C%22lastName%22%3A%22Charriere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viviane%22%2C%22lastName%22%3A%22Boulo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliette%22%2C%22lastName%22%3A%22Pouzadoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herve%22%2C%22lastName%22%3A%22Meudal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karine%22%2C%22lastName%22%3A%22Loth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Aucagne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%20F.%22%2C%22lastName%22%3A%22Delmas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Bulet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%5D%2C%22abstractNote%22%3A%22Big%20defensins%20are%20two-domain%20antimicrobial%20peptides%20%28AMPs%29%20that%20have%20highly%20diversified%20in%20mollusks.%20Cg-BigDefs%20are%20expressed%20by%20immune%20cells%20in%20the%20oyster%20Crassostrea%20gigas%2C%20and%20their%20expression%20is%20dampened%20during%20the%20Pacific%20Oyster%20Mortality%20Syndrome%20%28POMS%29%2C%20which%20evolves%20toward%20fatal%20bacteremia.%20We%20evaluated%20whether%20Cg-BigDefs%20contribute%20to%20the%20control%20of%20oyster-associated%20microbial%20communities.%20Two%20Cg-BigDefs%20that%20are%20representative%20of%20molecular%20diversity%20within%20the%20peptide%20family%2C%20namely%20Cg-BigDef1%20and%20Cg-BigDef5%2C%20were%20characterized%20by%20gene%20cloning%20and%20synthesized%20by%20solid-phase%20peptide%20synthesis%20and%20native%20chemical%20ligation.%20Synthetic%20peptides%20were%20tested%20for%20antibacterial%20activity%20against%20a%20collection%20of%20culturable%20bacteria%20belonging%20to%20the%20oyster%20microbiota%2C%20characterized%20by%2016S%20sequencing%20and%20MALDI%20Biotyping.%20We%20first%20tested%20the%20potential%20of%20Cg-BigDefs%20to%20control%20the%20oyster%20microbiota%20by%20injecting%20synthetic%20Cg-BigDef1%20into%20oyster%20tissues%20and%20analyzing%20microbiota%20dynamics%20over%2024%20h%20by%2016S%20metabarcoding.%20Cg-BigDef1%20induced%20a%20significant%20shift%20in%20oyster%20microbiota%20beta-diversity%20after%206%20h%20and%2024%20h%2C%20prompting%20us%20to%20investigate%20antimicrobial%20activities%20in%20vitro%20against%20members%20of%20the%20oyster%20microbiota.%20Both%20Cg-BigDef1%20and%20Cg-BigDef5%20were%20active%20at%20a%20high%20salt%20concentration%20%28400%20mM%20NaCl%29%20and%20showed%20broad%20spectra%20of%20activity%20against%20bacteria%20associated%20with%20C.%20gigas%20pathologies.%20Antimicrobial%20specificity%20was%20observed%20for%20both%20molecules%20at%20an%20intra-%20and%20inter-genera%20level.%20Remarkably%2C%20antimicrobial%20spectra%20of%20Cg-BigDef1%20and%20Cg-BigDef5%20were%20complementary%2C%20and%20peptides%20acted%20synergistically.%20Overall%2C%20we%20found%20that%20primary%20sequence%20diversification%20of%20Cg-BigDefs%20has%20generated%20specificity%20and%20synergy%20and%20extended%20the%20spectrum%20of%20activity%20of%20this%20peptide%20family.%22%2C%22date%22%3A%22DEC%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3390%5C%2Fmd20120745%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Fsummary%5C%2F8f92b190-4a98-40e7-a1a6-18362629beb2-6b5cc4d6%5C%2Frelevance%5C%2F1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%227BD5VS8S%22%5D%2C%22dateModified%22%3A%222023-01-19T10%3A20%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22LYNIUFHG%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Soree%20et%20al.%22%2C%22parsedDate%22%3A%222022-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESoree%2C%20M.%2C%20Delavat%2C%20F.%2C%20Lambert%2C%20C.%2C%20Lozach%2C%20S.%2C%20Papin%2C%20M.%2C%20Petton%2C%20B.%2C%20Passerini%2C%20D.%2C%20Degremont%2C%20L.%2C%20%26amp%3B%20Heath%2C%20D.%20H.%20%282022%29.%20Life%20history%20of%20oysters%20influences%20Vibrio%20parahaemolyticus%20accumulation%20in%20Pacific%20oysters%20%28Crassostrea%20gigas%29.%20%3Ci%3EEnvironmental%20Microbiology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1462-2920.15996%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1462-2920.15996%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DLYNIUFHG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life%20history%20of%20oysters%20influences%20Vibrio%20parahaemolyticus%20accumulation%20in%20Pacific%20oysters%20%28Crassostrea%20gigas%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marion%22%2C%22lastName%22%3A%22Soree%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois%22%2C%22lastName%22%3A%22Delavat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Solen%22%2C%22lastName%22%3A%22Lozach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathias%22%2C%22lastName%22%3A%22Papin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Passerini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Hervio%22%2C%22lastName%22%3A%22Heath%22%7D%5D%2C%22abstractNote%22%3A%22Vibrio%20parahaemolyticus%20infection%20in%20humans%20is%20associated%20with%20raw%20oyster%20consumption.%20Evaluation%20of%20V.%20parahaemolyticus%20presence%20in%20oysters%20is%20of%20most%20interest%20because%20of%20the%20economic%20and%20public%20health%20issues%20that%20it%20represents.%20To%20explore%20V.%20parahaemolyticus%20accumulation%20and%20depuration%20in%20adult%20Crassostrea%20gigas%2C%20we%20developed%20a%20GFP-tagged%20V.%20parahaemolyticus%20strain%20%28IFVp201-gfp%28%2B%29%29%2C%20as%20well%20as%20a%20rapid%20and%20efficient%20quantification%20method%20in%20C.%20gigas%20oysters%20haemolymph%20by%20flow%20cytometry.%20Impact%20of%20the%20life%20history%20of%20C.%20gigas%20on%20accumulation%20and%20depuration%20of%20V.%20parahaemolyticus%20IFVp201%20was%20subsequently%20investigated.%20We%20found%20that%20naive%20oysters%2C%20i.e.%20grown%20in%20controlled%20facilities%20with%20UV%20treated%20seawater%2C%20accumulated%20significantly%20more%20IFVp201%20than%20environmental%20oysters%2C%20i.e.%20grown%20in%20intertidal%20environment.%20We%20hypothesized%20that%20environmental%20oysters%20could%20have%20been%20immune%20primed%2C%20thus%20could%20limit%20V.%20parahaemolyticus%20accumulation.%20Meanwhile%2C%20both%20naive%20and%20environmental%20oysters%20had%20similar%20depuration%20rates.%22%2C%22date%22%3A%22SEP%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1111%5C%2F1462-2920.15996%22%2C%22ISSN%22%3A%221462-2912%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Fsummary%5C%2F805bf4b3-0090-4c34-bfe1-bb1b8ce00db2-3bcaf294%5C%2Frelevance%5C%2F1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%227BD5VS8S%22%5D%2C%22dateModified%22%3A%222022-11-03T12%3A38%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22XLQCV4UA%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lalau%20et%20al.%22%2C%22parsedDate%22%3A%222022-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELalau%2C%20N.%2C%20Van%20Wynsberge%2C%20S.%2C%20Soulard%2C%20B.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20%26amp%3B%20Le%20Gendre%2C%20R.%20%282022%29.%20A%20quick%20and%20cost-effective%20method%20for%20modelling%20water%20renewal%20in%20shallow%20coral%20reef%20lagoons.%20%3Ci%3ECoral%20Reefs%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00338-022-02319-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00338-022-02319-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DXLQCV4UA%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20quick%20and%20cost-effective%20method%20for%20modelling%20water%20renewal%20in%20shallow%20coral%20reef%20lagoons%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noemie%22%2C%22lastName%22%3A%22Lalau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Van%20Wynsberge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Soulard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Le%20Gendre%22%7D%5D%2C%22abstractNote%22%3A%22Water%20renewal%20exerts%20a%20preponderant%20role%20in%20eutrophication%2C%20yet%20few%20hydrodynamic%20indicators%20exist%20for%20performing%20quick%20and%20cost-effective%20assessments%20of%20ecosystem%20vulnerability.%20Using%20field%20data%2C%20we%20closed%20the%20water%20budget%20of%20a%20shallow%20coral%20reef%20lagoon%20recently%20exposed%20to%20high%20levels%20of%20nutrient%20loading%20that%20triggered%20green%20tides.%20Then%2C%20we%20tested%20the%20relevance%20of%20modelling%20flushing-time%2C%20a%20proxy%20of%20water%20renewal%2C%20from%20oceanic%20and%20atmospheric%20open%20access%20data.%20Water%20inflows%20in%20the%20lagoon%20were%20mainly%20driven%20by%20waves%20breaking%20on%20exposed%20reefs%2C%20but%20tide%20and%20wind%20also%20influenced%20water%20renewal%20during%20low-wave%20periods.%20Modelling%20flushing-time%20as%20a%20function%20of%20the%20wave%20features%20%28significant%20wave%20height%2C%20direction%2C%20and%20period%29%2C%20tide%2C%20and%20wind%20direction%20provided%20the%20most%20convincing%20model%2C%20with%20greater%20contribution%20of%20wave%20height%2C%20and%20adequately%20reproduced%20observations%20for%20an%20independent%20dataset.%20Using%20this%20model%20to%20hindcast%20flushing-time%20over%20the%20period%202000-2019%20highlighted%20that%20green%20tides%20that%20recently%20struck%20the%20area%20in%20January%202018%20and%20June%202019%20followed%20periods%20of%20slow%20water%20renewal%2C%20which%20therefore%20contributed%20to%20amplify%20the%20blooms.%20The%20analysis%20also%20demonstrated%20that%20renewal%20events%20even%20slower%20than%20those%20recorded%20in%202018-2019%20are%20frequent%20in%20this%20lagoon%2C%20which%20highlights%20the%20high%20vulnerability%20of%20this%20UNESCO%20World%20Heritage%20Site%20to%20other%20pulses%20of%20nutrient%20loading.%20Since%20the%20methodology%20developed%20in%20this%20study%20can%20be%20easily%20applied%20to%20many%20other%20coastal%20barrier%20and%20fringing%20reefs%2C%20it%20offers%20a%20promising%20perspective%20for%20quick%20and%20cost-effective%20assessments%20of%20coral%20reef%20vulnerability%20to%20eutrophication%20and%20other%20ecosystem%20crises%20magnified%20by%20slow%20water%20renewal.%22%2C%22date%22%3A%22OCT%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00338-022-02319-7%22%2C%22ISSN%22%3A%220722-4028%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%5D%2C%22dateModified%22%3A%222022-11-03T12%3A32%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22A6FESTYB%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Corporeau%20et%20al.%22%2C%22parsedDate%22%3A%222022-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECorporeau%2C%20C.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Vilaca%2C%20R.%2C%20Delisle%2C%20L.%2C%20Quere%2C%20C.%2C%20Le%20Roy%2C%20V.%2C%20Dubreuil%2C%20C.%2C%20Lacas-Gervais%2C%20S.%2C%20Guitton%2C%20Y.%2C%20Artigaud%2C%20S.%2C%20Bernay%2C%20B.%2C%20Pichereau%2C%20V.%2C%20Huvet%2C%20A.%2C%20Petton%2C%20B.%2C%20Pernet%2C%20F.%2C%20Fleury%2C%20E.%2C%20Madec%2C%20S.%2C%20Brigaudeau%2C%20C.%2C%20Brenner%2C%20C.%2C%20%26amp%3B%20Mazure%2C%20N.%20M.%20%282022%29.%20Harsh%20intertidal%20environment%20enhances%20metabolism%20and%20immunity%20in%20oyster%20%28Crassostrea%20gigas%29%20spat.%20%3Ci%3EMarine%20Environmental%20Research%3C%5C%2Fi%3E%2C%20%3Ci%3E180%3C%5C%2Fi%3E%2C%20105709.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.marenvres.2022.105709%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.marenvres.2022.105709%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DA6FESTYB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Harsh%20intertidal%20environment%20enhances%20metabolism%20and%20immunity%20in%20oyster%20%28Crassostrea%20gigas%29%20spat%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Corporeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romain%22%2C%22lastName%22%3A%22Vilaca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lizenn%22%2C%22lastName%22%3A%22Delisle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudie%22%2C%22lastName%22%3A%22Quere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valerian%22%2C%22lastName%22%3A%22Le%20Roy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Dubreuil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Lacas-Gervais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Guitton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Artigaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Bernay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vianney%22%2C%22lastName%22%3A%22Pichereau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Huvet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Madec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Brigaudeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20M.%22%2C%22lastName%22%3A%22Mazure%22%7D%5D%2C%22abstractNote%22%3A%22The%20Pacific%20oyster%20Crassostrea%20gigas%20is%20established%20in%20the%20marine%20intertidal%20zone%2C%20experiencing%20rapid%20and%20highly%20dynamic%20environmental%20changes%20throughout%20the%20tidal%20cycle.%20Depending%20on%20the%20bathymetry%2C%20oysters%20face%20oxygen%20deprivation%2C%20lack%20of%20nutrients%2C%20and%20high%20changes%20in%20temperature%20during%20alternation%20of%20the%20cycles%20of%20emersion%5C%2F%20immersion.%20Here%20we%20showed%20that%20intertidal%20oysters%20at%20a%20bathymetry%20level%20of%203%20and%205%20m%20delayed%20by%20ten%20days%20the%20onset%20of%20mortality%20associated%20with%20Pacific%20Oyster%20Mortality%20Syndrome%20%28POMS%29%20as%20compared%20to%20subtidal%20oysters.%20Intertidal%20oysters%20presented%20a%20lower%20growth%20but%20similar%20energetic%20reserves%20to%20subtidal%20oysters%20but%20induced%20pro-teomic%20changes%20indicative%20of%20a%20boost%20in%20metabolism%2C%20inflammation%2C%20and%20innate%20immunity%20that%20may%20have%20improved%20their%20resistance%20during%20infection%20with%20the%20Ostreid%20herpes%20virus.%20Our%20work%20highlights%20that%20intertidal%20harsh%20envi-ronmental%20conditions%20modify%20host-pathogen%20interaction%20and%20improve%20oyster%20health.%20This%20study%20opens%20new%20per-spectives%20on%20oyster%20farming%20for%20mitigation%20strategies%20based%20on%20tidal%20height.%22%2C%22date%22%3A%22SEP%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.marenvres.2022.105709%22%2C%22ISSN%22%3A%220141-1136%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Fsummary%5C%2F2a9be2a0-beb1-49ba-a5c1-34ef9a174b94-4f15af84%5C%2Frelevance%5C%2F1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%5D%2C%22dateModified%22%3A%222022-10-13T06%3A59%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22XGASZXD6%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Delmotte%20et%20al.%22%2C%22parsedDate%22%3A%222022-05-19%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDelmotte%2C%20J.%2C%20Pelletier%2C%20C.%2C%20Morga%2C%20B.%2C%20Galinier%2C%20R.%2C%20Petton%2C%20B.%2C%20Lamy%2C%20J.-B.%2C%20Kaltz%2C%20O.%2C%20Avarre%2C%20J.-C.%2C%20Jacquot%2C%20M.%2C%20Montagnani%2C%20C.%2C%20%26amp%3B%20Escoubas%2C%20J.-M.%20%282022%29.%20Genetic%20diversity%20and%20connectivity%20of%20the%20Ostreid%20herpesvirus%201%20populations%20in%20France%3A%20A%20first%20attempt%20to%20phylogeographic%20inference%20for%20a%20marine%20mollusc%20disease.%20%3Ci%3EVirus%20Evolution%3C%5C%2Fi%3E%2C%20%3Ci%3E8%3C%5C%2Fi%3E%281%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fve%5C%2Fveac039%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fve%5C%2Fveac039%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DXGASZXD6%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Genetic%20diversity%20and%20connectivity%20of%20the%20Ostreid%20herpesvirus%201%20populations%20in%20France%3A%20A%20first%20attempt%20to%20phylogeographic%20inference%20for%20a%20marine%20mollusc%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Delmotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Pelletier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Morga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Galinier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Baptiste%22%2C%22lastName%22%3A%22Lamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kaltz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Christophe%22%2C%22lastName%22%3A%22Avarre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maude%22%2C%22lastName%22%3A%22Jacquot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%5D%2C%22abstractNote%22%3A%22The%20genetic%20diversity%20of%20viral%20populations%20is%20a%20key%20driver%20of%20the%20spatial%20and%20temporal%20diffusion%20of%20viruses%3B%20yet%2C%20studying%20the%20diversity%20of%20whole%20genomes%20from%20natural%20populations%20still%20remains%20a%20challenge.%20Phylodynamic%20approaches%20are%20commonly%20used%20for%20RNA%20viruses%20harboring%20small%20genomes%20but%20have%20only%20rarely%20been%20applied%20to%20DNA%20viruses%20with%20larger%20genomes.%20Here%2C%20we%20used%20the%20Pacific%20oyster%20mortality%20syndrome%20%28a%20disease%20that%20affects%20oyster%20farms%20around%20the%20world%29%20as%20a%20model%20to%20study%20the%20genetic%20diversity%20of%20its%20causative%20agent%2C%20the%20Ostreid%20herpesvirus%201%20%28OsHV-1%29%20in%20the%20three%20main%20French%20oyster-farming%20areas.%20Using%20ultra-deep%20sequencing%20on%20individual%20moribund%20oysters%20and%20an%20innovative%20combination%20of%20bioinformatics%20tools%2C%20we%20de%20novo%20assembled%20twenty-one%20OsHV-1%20new%20genomes.%20Combining%20quantification%20of%20major%20and%20minor%20genetic%20variations%2C%20phylogenetic%20analysis%2C%20and%20ancestral%20state%20reconstruction%20of%20discrete%20traits%20approaches%2C%20we%20assessed%20the%20connectivity%20of%20OsHV-1%20viral%20populations%20between%20the%20three%20oyster-farming%20areas.%20Our%20results%20suggest%20that%20the%20Marennes-Oleron%20Bay%20represents%20the%20main%20source%20of%20OsHV-1%20diversity%2C%20from%20where%20the%20virus%20has%20dispersed%20to%20other%20farming%20areas%2C%20a%20scenario%20consistent%20with%20current%20practices%20of%20oyster%20transfers%20in%20France.%20We%20demonstrate%20that%20phylodynamic%20approaches%20can%20be%20applied%20to%20aquatic%20DNA%20viruses%20to%20determine%20how%20epidemiological%2C%20immunological%2C%20and%20evolutionary%20processes%20act%20and%20potentially%20interact%20to%20shape%20their%20diversity%20patterns.%22%2C%22date%22%3A%22MAY%2019%202022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1093%5C%2Fve%5C%2Fveac039%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Fsummary%5C%2F06eb1d7b-88df-44ce-b60b-51b49d1e9425-3bcb22ef%5C%2Frelevance%5C%2F1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%227BD5VS8S%22%5D%2C%22dateModified%22%3A%222022-06-02T13%3A46%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22B9AN5L3K%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Poppeschi%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-21%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPoppeschi%2C%20C.%2C%20Charria%2C%20G.%2C%20Goberville%2C%20E.%2C%20Rimmelin-Maury%2C%20P.%2C%20Barrier%2C%20N.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Unterberger%2C%20M.%2C%20Grossteffan%2C%20E.%2C%20Repecaud%2C%20M.%2C%20Quemener%2C%20L.%2C%20Theetten%2C%20S.%2C%20Le%20Roux%2C%20J.-F.%2C%20%26amp%3B%20Tr%26%23xE9%3Bguer%2C%20P.%20%282021%29.%20Unraveling%20Salinity%20Extreme%20Events%20in%20Coastal%20Environments%3A%20A%20Winter%20Focus%20on%20the%20Bay%20of%20Brest.%20%3Ci%3EFrontiers%20in%20Marine%20Science%3C%5C%2Fi%3E%2C%20%3Ci%3E8%3C%5C%2Fi%3E%2C%20705403.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmars.2021.705403%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmars.2021.705403%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DB9AN5L3K%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Unraveling%20Salinity%20Extreme%20Events%20in%20Coastal%20Environments%3A%20A%20Winter%20Focus%20on%20the%20Bay%20of%20Brest%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Coline%22%2C%22lastName%22%3A%22Poppeschi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Charria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Goberville%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peggy%22%2C%22lastName%22%3A%22Rimmelin-Maury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Barrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maximilian%22%2C%22lastName%22%3A%22Unterberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emilie%22%2C%22lastName%22%3A%22Grossteffan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michel%22%2C%22lastName%22%3A%22Repecaud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loic%22%2C%22lastName%22%3A%22Quemener%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Theetten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Francois%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Tr%5Cu00e9guer%22%7D%5D%2C%22abstractNote%22%3A%22Extreme%20weather%20events%20affect%20coastal%20marine%20ecosystems.%20The%20increase%20in%20intensity%20and%20occurrence%20of%20such%20events%20drive%20modifications%20in%20coastal%20hydrology%20and%20hydrodynamics.%20Here%2C%20focusing%20on%20the%20winter%20period%20%28from%20December%20to%20March%29%2C%20we%20investigated%20multidecade%20%282000-2018%29%20changes%20in%20the%20hydrological%20properties%20of%20the%20Bay%20of%20Brest%20%28French%20Atlantic%20coast%29%20as%20an%20example%20of%20the%20response%20of%20a%20semi-enclosed%20bay%20to%20extreme%20weather%20episodes%20and%20large-scale%20atmospheric%20circulation%20patterns.%20The%20relationships%20between%20extreme%20weather%20events%20and%20severe%20low%20salinity%20conditions%20%28as%20a%20proxy%20for%20changes%20in%20water%20density%29%20were%20investigated%20using%20high-frequency%20in%20situ%20observations%20and%20high-resolution%20numerical%20simulations.%20The%20identification%20of%20intense%20episodes%20was%20based%20on%20the%20timing%2C%20duration%2C%20and%20annual%20occurrence%20of%20extreme%20events.%20By%20examining%20the%20interannual%20variability%20of%20extreme%20low%20salinity%20events%2C%20we%20detect%20a%20patent%20influence%20of%20local%20and%20regional%20weather%20conditions%20on%20atmospheric%20and%20oceanic%20circulation%20patterns%2C%20precipitation%2C%20and%20river%20runoff.%20We%20revealed%20that%20low%20salinity%20events%20in%20Brittany%20were%20controlled%20by%20large-scale%20forcings%3A%20they%20prevailed%20during%20the%20positive%20phase%20of%20the%20North%20Atlantic%20Oscillation%20and%20periods%20of%20low%20occurrences%20of%20the%20Atlantic%20Ridge%20weather%20regime.%20The%20increase%20in%20severe%20storms%20observed%20in%20western%20France%20since%202010%20has%20led%20to%20a%20doubling%20of%20the%20occurrence%20and%20duration%20of%20extreme%20low%20salinity%20events%20in%20Brittany.%22%2C%22date%22%3A%22JUL%2021%202021%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3389%5C%2Ffmars.2021.705403%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Ffull-record%5C%2FWOS%3A000680032400001%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22PCQMC87R%22%5D%2C%22dateModified%22%3A%222022-04-07T07%3A08%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22NLXEP3CW%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dugeny%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDugeny%2C%20E.%2C%20de%20Lorgeril%2C%20J.%2C%20Petton%2C%20B.%2C%20Toulza%2C%20E.%2C%20Gueguen%2C%20Y.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282022%29.%20Seaweeds%20influence%20oyster%20microbiota%20and%20disease%20susceptibility.%20%3Ci%3EJournal%20of%20Animal%20Ecology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1365-2656.13662%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1365-2656.13662%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DNLXEP3CW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Seaweeds%20influence%20oyster%20microbiota%20and%20disease%20susceptibility%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elyne%22%2C%22lastName%22%3A%22Dugeny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22A%20growing%20awareness%20of%20role%20that%20microbiota%20can%20play%20in%20mediating%20the%20effects%20of%20pathogens%20on%20hosts%20has%20given%20rise%20to%20the%20concept%20of%20the%20pathobiome.%20Recently%2C%20we%20demonstrated%20that%20the%20Pacific%20oyster%20mortality%20syndrome%20affecting%20Crassostrea%20gigas%20oysters%20is%20caused%20by%20infection%20with%20the%20Ostreid%20herpesvirus%20type%201%20%28OsHV-1%29%20followed%20by%20infection%20with%20multiple%20bacterial%20taxa.%20Here%20we%20extend%20the%20concept%20of%20this%20pathobiome%20beyond%20the%20host%20species%20and%20its%20bacterial%20microbiota%20by%20investigating%20how%20seaweed%20living%20in%20association%20with%20oysters%20influences%20their%20response%20to%20the%20disease.%20We%20hypothesized%20that%20by%20their%20mere%20presence%20in%20the%20environment%2C%20different%20species%20of%20seaweeds%20can%20positively%20or%20negatively%20influence%20the%20risk%20of%20disease%20in%20oysters%20by%20shaping%20their%20bacterial%20microbiota%20and%20their%20immune%20response.%20Although%20seaweed%20and%20oysters%20do%20not%20have%20direct%20ecological%20interactions%2C%20they%20are%20connected%20by%20seawater%20and%20likely%20share%20microbes.%20To%20test%20our%20hypothesis%2C%20oysters%20were%20acclimated%20with%20green%2C%20brown%20or%20red%20algae%20for%202%20weeks%20and%20then%20challenged%20with%20OsHV-1.%20We%20monitored%20host%20survival%20and%20pathogen%20proliferation%20and%20performed%20bacterial%20microbiota%20and%20transcriptome%20analyses.%20We%20found%20that%20seaweeds%20can%20alter%20the%20bacterial%20microbiota%20of%20the%20host%20and%20its%20response%20to%20the%20disease.%20More%20particularly%2C%20green%20algae%20belonging%20to%20the%20genus%20Ulva%20spp.%20induced%20bacterial%20microbiota%20dysbiosis%20in%20oyster%20and%20modification%20of%20its%20transcriptional%20immune%20response%20leading%20to%20increased%20susceptibility%20to%20the%20disease.%20This%20work%20provides%20a%20better%20understanding%20of%20a%20marine%20disease%20and%20highlights%20the%20importance%20of%20considering%20both%20macrobiotic%20and%20microbiotic%20interactions%20for%20conservation%2C%20management%20and%20exploitation%20of%20marine%20ecosystems%20and%20resources.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1111%5C%2F1365-2656.13662%22%2C%22ISSN%22%3A%220021-8790%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Fsummary%5C%2Fc3d8fd6e-1e5e-48fe-a868-6fda1aa10fa6-2a9ab2e9%5C%2Frelevance%5C%2F1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%2C%227BD5VS8S%22%5D%2C%22dateModified%22%3A%222022-03-28T07%3A03%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22T228UYTL%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Offret%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOffret%2C%20C.%2C%20Gauthier%2C%20O.%2C%20Despreaux%2C%20G.%2C%20Bidault%2C%20A.%2C%20Corporeau%2C%20C.%2C%20Miner%2C%20P.%2C%20Petton%2C%20B.%2C%20Pernet%2C%20F.%2C%20Fabioux%2C%20C.%2C%20Paillard%2C%20C.%2C%20%26amp%3B%20Le%20Blay%2C%20G.%20%282022%29.%20Microbiota%20of%20the%20Digestive%20Glands%20and%20Extrapallial%20Fluids%20of%20Clams%20Evolve%20Differently%20Over%20Time%20Depending%20on%20the%20Intertidal%20Position.%20%3Ci%3EMicrobial%20Ecology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00248-022-01959-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00248-022-01959-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DT228UYTL%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Microbiota%20of%20the%20Digestive%20Glands%20and%20Extrapallial%20Fluids%20of%20Clams%20Evolve%20Differently%20Over%20Time%20Depending%20on%20the%20Intertidal%20Position%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clement%22%2C%22lastName%22%3A%22Offret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Garance%22%2C%22lastName%22%3A%22Despreaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adeline%22%2C%22lastName%22%3A%22Bidault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Corporeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Miner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Fabioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Paillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gwenaelle%22%2C%22lastName%22%3A%22Le%20Blay%22%7D%5D%2C%22abstractNote%22%3A%22The%20Manila%20clam%20%28Ruditapes%20philippinarum%29%20is%20the%20second%20most%20exploited%20bivalve%20in%20the%20world%20but%20remains%20threatened%20by%20diseases%20and%20global%20changes.%20Their%20associated%20microbiota%20play%20a%20key%20role%20in%20their%20fitness%20and%20acclimation%20capacities.%20This%20study%20aimed%20at%20better%20understanding%20the%20behavior%20of%20clam%20digestive%20glands%20and%20extrapallial%20fluids%20microbiota%20at%20small%2C%20but%20contrasting%20spatial%20and%20temporal%20scales.%20Results%20showed%20that%20environmental%20variations%20impacted%20clam%20microbiota%20differently%20according%20to%20the%20considered%20tissue.%20Each%20clam%20tissue%20presented%20its%20own%20microbiota%20and%20showed%20different%20dynamics%20according%20to%20the%20intertidal%20position%20and%20sampling%20period.%20Extrapallial%20fluids%20microbiota%20was%20modified%20more%20rapidly%20than%20digestive%20glands%20microbiota%2C%20for%20clams%20placed%20on%20the%20upper%20and%20lower%20intertidal%20position%2C%20respectively.%20Clam%20tissues%20could%20be%20considered%20as%20different%20microhabitats%20for%20bacteria%20as%20they%20presented%20different%20responses%20to%20small-scale%20temporal%20and%20spatial%20variabilities%20in%20natural%20conditions.%20These%20differences%20underlined%20a%20more%20stringent%20environmental%20filter%20capacity%20of%20the%20digestive%20glands.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00248-022-01959-0%22%2C%22ISSN%22%3A%220095-3628%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.webofscience.com%5C%2Fwos%5C%2Fwoscc%5C%2Fsummary%5C%2F095d808d-59dc-4194-a611-a6a0c17d3de6-21bc706a%5C%2Frelevance%5C%2F1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22449H35DA%22%5D%2C%22dateModified%22%3A%222022-03-28T07%3A02%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22J3FCF7Y2%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Petton%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-18%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPetton%2C%20B.%2C%20Destoumieux-Garzon%2C%20D.%2C%20Pernet%2C%20F.%2C%20Toulza%2C%20E.%2C%20de%20Lorgeril%2C%20J.%2C%20Degremont%2C%20L.%2C%20%26amp%3B%20Mitta%2C%20G.%20%282021%29.%20The%20Pacific%20Oyster%20Mortality%20Syndrome%2C%20a%20Polymicrobial%20and%20Multifactorial%20Disease%3A%20State%20of%20Knowledge%20and%20Future%20Directions.%20%3Ci%3EFrontiers%20in%20Immunology%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%2C%20630343.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffimmu.2021.630343%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffimmu.2021.630343%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DJ3FCF7Y2%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Pacific%20Oyster%20Mortality%20Syndrome%2C%20a%20Polymicrobial%20and%20Multifactorial%20Disease%3A%20State%20of%20Knowledge%20and%20Future%20Directions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%5D%2C%22abstractNote%22%3A%22The%20Pacific%20oyster%20%28Crassostreae%20gigas%29%20has%20been%20introduced%20from%20Asia%20to%20numerous%20countries%20around%20the%20world%20during%20the%2020th%20century.%20C.%20gigas%20is%20the%20main%20oyster%20species%20farmed%20worldwide%20and%20represents%20more%20than%2098%25%20of%20oyster%20production.%20The%20severity%20of%20disease%20outbreaks%20that%20affect%20C.%20gigas%2C%20which%20primarily%20impact%20juvenile%20oysters%2C%20has%20increased%20dramatically%20since%202008.%20The%20most%20prevalent%20disease%2C%20Pacific%20oyster%20mortality%20syndrome%20%28POMS%29%2C%20has%20become%20panzootic%20and%20represents%20a%20threat%20to%20the%20oyster%20industry.%20Recently%2C%20major%20steps%20towards%20understanding%20POMS%20have%20been%20achieved%20through%20integrative%20molecular%20approaches.%20These%20studies%20demonstrated%20that%20infection%20by%20Ostreid%20herpesvirus%20type%201%20mu%20Var%20%28OsHV-1%20mu%20var%29%20is%20the%20first%20critical%20step%20in%20the%20infectious%20process%20and%20leads%20to%20an%20immunocompromised%20state%20by%20altering%20hemocyte%20physiology.%20This%20is%20followed%20by%20dysbiosis%20of%20the%20microbiota%2C%20which%20leads%20to%20a%20secondary%20colonization%20by%20opportunistic%20bacterial%20pathogens%2C%20which%20in%20turn%20results%20in%20oyster%20death.%20Host%20and%20environmental%20factors%20%28e.g.%20oyster%20genetics%20and%20age%2C%20temperature%2C%20food%20availability%2C%20and%20microbiota%29%20have%20been%20shown%20to%20influence%20POMS%20permissiveness.%20However%2C%20we%20still%20do%20not%20understand%20the%20mechanisms%20by%20which%20these%20different%20factors%20control%20disease%20expression.%20The%20present%20review%20discusses%20current%20knowledge%20of%20this%20polymicrobial%20and%20multifactorial%20disease%20process%20and%20explores%20the%20research%20avenues%20that%20must%20be%20investigated%20to%20fully%20elucidate%20the%20complexity%20of%20POMS.%20These%20discoveries%20will%20help%20in%20decision-making%20and%20will%20facilitate%20the%20development%20of%20tools%20and%20applied%20innovations%20for%20the%20sustainable%20and%20integrated%20management%20of%20oyster%20aquaculture.%22%2C%22date%22%3A%22FEB%2018%202021%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3389%5C%2Ffimmu.2021.630343%22%2C%22ISSN%22%3A%221664-3224%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22PCQMC87R%22%5D%2C%22dateModified%22%3A%222021-06-20T15%3A05%3A10Z%22%7D%7D%2C%7B%22key%22%3A%222LN5SPC5%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pernet%20et%20al.%22%2C%22parsedDate%22%3A%222021-04%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPernet%2C%20F.%2C%20Lugue%2C%20K.%2C%20%26amp%3B%20Petton%2C%20B.%20%282021%29.%20Competition%20for%20food%20reduces%20disease%20susceptibility%20in%20a%20marine%20invertebrate.%20%3Ci%3EEcosphere%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%284%29%2C%20e03435.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fecs2.3435%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fecs2.3435%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D2LN5SPC5%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Competition%20for%20food%20reduces%20disease%20susceptibility%20in%20a%20marine%20invertebrate%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klervi%22%2C%22lastName%22%3A%22Lugue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%5D%2C%22abstractNote%22%3A%22Competition%20between%20organisms%20interfere%20in%20host%20and%20pathogen%20dynamics%20in%20ways%20that%20are%20difficult%20to%20predict.%20By%20one%20side%2C%20competitors%20can%20reduce%20the%20food%20supply%20and%20cause%20nutritional%20stress.%20Such%20stress%20could%20further%20modulate%20the%20susceptibility%20to%20infection%20by%20altering%20immune%20response%20or%20metabolic%20rate%20of%20the%20host.%20Alternatively%2C%20competitors%20may%20trap%20pathogens%20before%20they%20reach%20the%20focal%20host%2C%20and%20therefore%20reduce%2C%20enhance%2C%20or%20have%20no%20effect%20on%20infection%20according%20to%20the%20competitor%27s%20susceptibility%20to%20the%20infection.%20To%20better%20understand%20how%20competition%20influences%20host%20and%20pathogen%20interactions%2C%20we%20experimentally%20assessed%20the%20relative%20importance%20of%20competition%20for%20pathogens%20and%20resources%20on%20the%20severity%20of%20a%20viral%20disease%20infecting%20the%20Pacific%20oyster%20Crassostrea%20gigas.%20We%20designed%20an%20open-flow%20system%20where%20food%20enriched%20seawater%20flowed%20to%20filter-feeding%20competitors%20%28or%20empty%20controls%29%20before%20being%20delivered%20to%20recipient%20oysters.%20We%20tested%20a%20range%20of%20competing%20species%20that%20exhibit%20both%20low%20%28ascidians%2C%20European%20oysters%2C%20mussels%29%20and%20high%20%28Pacific%20oysters%29%20susceptibility%20to%20the%20virus.%20We%20assessed%20the%20physiological%20condition%20of%20the%20recipient%20oysters%20during%20acclimation%2C%20we%20added%20virus-contaminated%20seawater%20upstream%20of%20the%20distribution%20system%2C%20and%20we%20monitored%20host%20and%20pathogen%20dynamics.%20We%20found%20that%20the%20presence%20of%20competitors%2C%20regardless%20of%20susceptibility%20to%20the%20virus%2C%20indirectly%20reduced%20the%20infection%20rate%20of%20hosts%20by%20decreasing%20their%20food%20ingestion%20and%20growth%20rates.%20Although%20competitors%20can%20reduce%20viral%20particles%20from%20the%20seawater%2C%20this%20had%20no%20effect%20on%20the%20host%20population.%20Our%20data%20suggest%20that%20the%20effect%20of%20competition%20for%20food%20overwhelmed%20that%20of%20competition%20for%20pathogens%2C%20thus%20emphasizing%20the%20importance%20of%20considering%20resource%20availability%20in%20host%20and%20pathogen%20dynamics.%20More%20particularly%2C%20resource%20availability%20can%20have%20positive%20effects%20at%20the%20individual%20level%2C%20fostering%20physiological%20condition%20and%20growth%2C%20but%20negative%20effects%20at%20the%20population%20level%2C%20increasing%20magnitude%20of%20epidemics.%22%2C%22date%22%3A%22APR%202021%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1002%5C%2Fecs2.3435%22%2C%22ISSN%22%3A%222150-8925%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fesajournals.onlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fecs2.3435%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22PCQMC87R%22%5D%2C%22dateModified%22%3A%222021-06-20T14%3A54%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22TCK7F2AF%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Offret%20et%20al.%22%2C%22parsedDate%22%3A%222020-08%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOffret%2C%20C.%2C%20Paulino%2C%20S.%2C%20Gauthier%2C%20O.%2C%20Chateau%2C%20K.%2C%20Bidault%2C%20A.%2C%20Corporeau%2C%20C.%2C%20Miner%2C%20P.%2C%20Petton%2C%20B.%2C%20Pernet%2C%20F.%2C%20Fabioux%2C%20C.%2C%20Paillard%2C%20C.%2C%20%26amp%3B%20Le%20Blay%2C%20G.%20%282020%29.%20The%20marine%20intertidal%20zone%20shapes%20oyster%20and%20clam%20digestive%20bacterial%20microbiota.%20%3Ci%3EFems%20Microbiology%20Ecology%3C%5C%2Fi%3E%2C%20%3Ci%3E96%3C%5C%2Fi%3E%288%29%2C%20fiaa078.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Ffemsec%5C%2Ffiaa078%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Ffemsec%5C%2Ffiaa078%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DTCK7F2AF%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20marine%20intertidal%20zone%20shapes%20oyster%20and%20clam%20digestive%20bacterial%20microbiota%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clement%22%2C%22lastName%22%3A%22Offret%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sauvann%22%2C%22lastName%22%3A%22Paulino%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Chateau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adeline%22%2C%22lastName%22%3A%22Bidault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Corporeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Miner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Fabioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Paillard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gwenaelle%22%2C%22lastName%22%3A%22Le%20Blay%22%7D%5D%2C%22abstractNote%22%3A%22Digestive%20microbiota%20provide%20a%20wide%20range%20of%20beneficial%20effects%20on%20host%20physiology%20and%20are%20therefore%20likely%20to%20play%20a%20key%20role%20in%20marine%20intertidal%20bivalve%20ability%20to%20acclimatize%20to%20the%20intertidal%20zone.%20This%20study%20investigated%20the%20effect%20of%20intertidal%20levels%20on%20the%20digestive%20bacterial%20microbiota%20of%20oysters%20%28Crassostrea%20gigas%29%20and%20clams%20%28Ruditapes%20philippinarum%29%2C%20two%20bivalves%20with%20different%20ecological%20niches.%20Based%20on%2016S%20rRNA%20region%20sequencing%2C%20digestive%20glands%2C%20seawater%20and%20sediments%20harbored%20specific%20bacterial%20communities%2C%20dominated%20by%20operational%20taxonomic%20units%20assigned%20to%20the%20Mycoplasmatales%2C%20Desulfobacterales%20and%20Rhodobacterales%20orders%2C%20respectively.%20Field%20implantation%20modified%20digestive%20bacterial%20microbiota%20of%20both%20bivalve%20species%20according%20to%20their%20intertidal%20position.%20Rhodospirillales%20and%20Legionellales%20abundances%20increased%20in%20oysters%20and%20clams%20from%20the%20low%20intertidal%20level%2C%20respectively.%20After%20a%2014-day%20depuration%20process%2C%20these%20effects%20were%20still%20observed%2C%20especially%20for%20clams%2C%20while%20digestive%20bacterial%20microbiota%20of%20oysters%20were%20subjected%20to%20more%20short-term%20environmental%20changes.%20Nevertheless%2C%203.5%20months%20stay%20on%20an%20intertidal%20zone%20was%20enough%20to%20leave%20an%20environmental%20footprint%20on%20the%20digestive%20bacterial%20microbiota%2C%20suggesting%20the%20existence%20of%20autochthonous%20bivalve%20bacteria.%20When%20comparing%20clams%20from%20the%20three%20intertidal%20levels%2C%2020%25%20of%20the%20bacterial%20assemblage%20was%20shared%20among%20the%20levels%20and%20it%20was%20dominated%20by%20an%20operational%20taxonomic%20unit%20affiliated%20to%20the%20Mycoplasmataceae%20and%20Spirochaetaceae%20families.%22%2C%22date%22%3A%22AUG%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1093%5C%2Ffemsec%5C%2Ffiaa078%22%2C%22ISSN%22%3A%220168-6496%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Ffemsec%5C%2Farticle%5C%2F96%5C%2F8%5C%2Ffiaa078%5C%2F5827529%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A42%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22QQRMK4CY%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Clerissi%20et%20al.%22%2C%22parsedDate%22%3A%222020-02-27%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EClerissi%2C%20C.%2C%20de%20Lorgeril%2C%20J.%2C%20Petton%2C%20B.%2C%20Lucasson%2C%20A.%2C%20Escoubas%2C%20J.-M.%2C%20Gueguen%2C%20Y.%2C%20Degremont%2C%20L.%2C%20Mitta%2C%20G.%2C%20%26amp%3B%20Toulza%2C%20E.%20%282020%29.%20Microbiota%20Composition%20and%20Evenness%20Predict%20Survival%20Rate%20of%20Oysters%20Confronted%20to%20Pacific%20Oyster%20Mortality%20Syndrome.%20%3Ci%3EFrontiers%20in%20Microbiology%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%2C%20311.%20https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00621%5C%2F73332%5C%2F.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2020.00311%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2020.00311%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DQQRMK4CY%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Microbiota%20Composition%20and%20Evenness%20Predict%20Survival%20Rate%20of%20Oysters%20Confronted%20to%20Pacific%20Oyster%20Mortality%20Syndrome%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Clerissi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aude%22%2C%22lastName%22%3A%22Lucasson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%5D%2C%22abstractNote%22%3A%22Pacific%20Oyster%20Mortality%20Syndrome%20%28POMS%29%20affects%20Crassostrea%20gigas%20oysters%20worldwide%20and%20causes%20important%20economic%20losses.%20Disease%20dynamic%20was%20recently%20deciphered%20and%20revealed%20a%20multiple%20and%20progressive%20infection%20caused%20by%20the%20Ostreid%20herpesvirus%20OsHV-1%20mu%20Var%2C%20triggering%20an%20immunosuppression%20followed%20by%20microbiota%20destabilization%20and%20bacteraemia%20by%20opportunistic%20bacterial%20pathogens.%20However%2C%20it%20remains%20unknown%20if%20microbiota%20might%20participate%20to%20protect%20oysters%20against%20POMS%2C%20and%20if%20microbiota%20characteristics%20might%20be%20predictive%20of%20oyster%20mortalities.%20To%20tackle%20this%20issue%2C%20we%20transferred%20full-sib%20progenies%20of%20resistant%20and%20susceptible%20oyster%20families%20from%20hatchery%20to%20the%20field%20during%20a%20period%20in%20favor%20of%20POMS.%20After%205%20days%20of%20transplantation%2C%20oysters%20from%20each%20family%20were%20either%20sampled%20for%20individual%20microbiota%20analyses%20using%2016S%20rRNA%20gene-metabarcoding%20or%20transferred%20into%20facilities%20to%20record%20their%20survival%20using%20controlled%20condition.%20As%20expected%2C%20all%20oysters%20from%20susceptible%20families%20died%2C%20and%20all%20oysters%20from%20the%20resistant%20family%20survived.%20Quantification%20of%20OsHV-1%20and%20bacteria%20showed%20that%205%20days%20of%20transplantation%20were%20long%20enough%20to%20contaminate%20oysters%20by%20POMS%2C%20but%20not%20for%20entering%20the%20pathogenesis%20process.%20Thus%2C%20it%20was%20possible%20to%20compare%20microbiota%20characteristics%20between%20resistant%20and%20susceptible%20oysters%20families%20at%20the%20early%20steps%20of%20infection.%20Strikingly%2C%20we%20found%20that%20microbiota%20evenness%20and%20abundances%20of%20Cyanobacteria%20%28Subsection%20III%2C%20family%20I%29%2C%20Mycoplasmataceae%2C%20Rhodobacteraceae%2C%20and%20Rhodospirillaceae%20were%20significantly%20different%20between%20resistant%20and%20susceptible%20oyster%20families.%20We%20concluded%20that%20these%20microbiota%20characteristics%20might%20predict%20oyster%20mortalities.%22%2C%22date%22%3A%22FEB%2027%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3389%5C%2Ffmicb.2020.00311%22%2C%22ISSN%22%3A%221664-302X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A28%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22XKEMWQBD%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fleury%20et%20al.%22%2C%22parsedDate%22%3A%222020-04-29%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFleury%2C%20E.%2C%20Barbier%2C%20P.%2C%20Petton%2C%20B.%2C%20Normand%2C%20J.%2C%20Thomas%2C%20Y.%2C%20Pouvreau%2C%20S.%2C%20Daigle%2C%20G.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282020%29.%20Latitudinal%20drivers%20of%20oyster%20mortality%3A%20deciphering%20host%2C%20pathogen%20and%20environmental%20risk%20factors.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%281%29%2C%207264.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-64086-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-64086-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DXKEMWQBD%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Latitudinal%20drivers%20of%20oyster%20mortality%3A%20deciphering%20host%2C%20pathogen%20and%20environmental%20risk%20factors%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierrick%22%2C%22lastName%22%3A%22Barbier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Normand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoann%22%2C%22lastName%22%3A%22Thomas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22Pouvreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaetan%22%2C%22lastName%22%3A%22Daigle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22Diseases%20pose%20an%20ongoing%20threat%20to%20aquaculture%2C%20fisheries%20and%20conservation%20of%20marine%20species%2C%20and%20determination%20of%20risk%20factors%20of%20disease%20is%20crucial%20for%20management.%20Our%20objective%20was%20to%20decipher%20the%20effects%20of%20host%2C%20pathogen%20and%20environmental%20factors%20on%20disease-induced%20mortality%20of%20Pacific%20oysters%20%28Crassostrea%20gigas%29%20across%20a%20latitudinal%20gradient.%20We%20deployed%20young%20and%20adult%20oysters%20at%2013%20sites%20in%20France%20and%20we%20monitored%20survival%2C%20pathogens%20and%20environmental%20parameters.%20The%20young%20oysters%20came%20from%20either%20the%20wild%20collection%20or%20the%20hatchery%20while%20the%20adults%20were%20from%20the%20wild%20only.%20We%20then%20used%20Cox%20regression%20models%20to%20investigate%20the%20effect%20of%20latitude%2C%20site%2C%20environmental%20factors%20and%20origin%20on%20mortality%20risk%20and%20to%20extrapolate%20this%20mortality%20risk%20to%20the%20distribution%20limits%20of%20the%20species%20in%20Europe.%20We%20found%20that%20seawater%20temperature%2C%20food%20level%2C%20sea%20level%20atmospheric%20pressure%2C%20rainfall%20and%20wind%20speed%20were%20associated%20with%20mortality%20risk.%20Their%20effect%20on%20hatchery%20oysters%20was%20generally%20higher%20than%20on%20wild%20animals%2C%20probably%20reflecting%20that%20hatchery%20oysters%20were%20free%20of%20Ostreid%20herpesvirus%201%20%28OsHV-1%29%20whereas%20those%20from%20the%20wild%20were%20asymptomatic%20carriers.%20The%20risk%20factors%20involved%20in%20young%20and%20adult%20oyster%20mortalities%20were%20different%2C%20reflecting%20distinct%20diseases.%20Mortality%20risk%20increases%20from%200%20to%2090%25%20with%20decreasing%20latitude%20for%20young%20hatchery%20oysters%2C%20but%20not%20for%20young%20wild%20oysters%20or%20adults.%20Mortality%20risk%20was%20higher%20in%20wild%20oysters%20than%20in%20hatchery%20ones%20at%20latitude%20%3E%2047.6%20degrees%20N%20while%20this%20was%20the%20opposite%20at%20lower%20latitude.%20Therefore%2C%20latitudinal%20gradient%20alters%20disease-induced%20mortality%20risk%20but%20interacts%20with%20the%20initial%20health%20status%20of%20the%20host%20and%20the%20pathogen%20involved.%20Practically%2C%20we%20suggest%20that%20mortality%20can%20be%20mitigated%20by%20using%20hatchery%20oysters%20in%20north%20and%20wild%20collected%20oysters%20in%20the%20south.%22%2C%22date%22%3A%22APR%2029%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-020-64086-1%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-020-64086-1%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A21%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22DRMIR4TL%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Petton%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Pouvreau%2C%20S.%2C%20%26amp%3B%20Dumas%2C%20F.%20%282020%29.%20Intensive%20use%20of%20Lagrangian%20trajectories%20to%20quantify%20coastal%20area%20dispersion.%20%3Ci%3EOcean%20Dynamics%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10236-019-01343-6%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10236-019-01343-6%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DDRMIR4TL%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intensive%20use%20of%20Lagrangian%20trajectories%20to%20quantify%20coastal%20area%20dispersion%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22Pouvreau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franck%22%2C%22lastName%22%3A%22Dumas%22%7D%5D%2C%22abstractNote%22%3A%22Coastal%20waters%20are%20subject%20to%20great%20environmental%20and%20anthropogenic%20pressures.%20The%20diffusion%20and%20the%20transport%20of%20these%20waters%20are%20a%20key%20element%20for%20environmental%2C%20ecological%20and%20economic%20management.%20There%20are%20numerous%20indicators%20of%20hydrological%20characteristics%20based%20on%20theories%20of%20transport%20time%20scale.%20However%2C%20these%20indicators%20strongly%20depend%20on%20the%20geographical%20shape%20of%20the%20studied%20area%20and%20tend%20to%20give%20information%20after%20long%20integration%20time%20periods%2C%20generally%20on%20the%20order%20of%20weeks.%20Here%2C%20to%20qualify%20a%20coastal%20area%27s%20dispersion%20more%20precisely%2C%20we%20combined%20two%20Lagrangian%20approaches%20and%20estimated%20a%20local%20diffusivity.%20This%20paper%20presents%20the%20numerical%20implementation%20and%20the%20results%20obtained%20over%20a%20tidally%20flushed%2C%20semi-enclosed%20water%20body%20located%20at%20mid-latitude.%20This%20new%20coefficient%20was%20estimated%20using%20the%20hydrodynamic%20model%20MARS%203D%20with%20a%20barycentric%20repositioning%20technique%20over%20a%20tidal%20period%20to%20ensure%20its%20reliability.%20We%20highlight%20the%20existing%20relationships%20between%20local%20diffusivity%20and%20both%20horizontal%20and%20vertical%20processes.%20Methodological%20aspects%20were%20analysed%20based%20on%20a%20reference%20case%20%28number%20and%20distribution%20of%20particles%2C%20resolution%2C%20integration%20time%20period%29.%20The%20consistency%20and%20sensitivity%20of%20the%20coefficient%20were%20studied%20with%20different%20forcing%20conditions%20%28hydrodynamical%20and%20meteorological%20regimes%29.%20In%20conclusion%2C%20our%20local%20diffusivity%20provides%20a%20new%20perspective%20for%20understanding%20the%20land-sea%20interface%20and%20coastal%20dispersion%20and%20holds%20potential%20for%20future%20studies%20of%20coastal%20marine%20ecosystems.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10236-019-01343-6%22%2C%22ISSN%22%3A%221616-7341%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2Farticle%5C%2F10.1007%5C%2Fs10236-019-01343-6%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A20%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22H9DEHIWN%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Lorgeril%20et%20al.%22%2C%22parsedDate%22%3A%222020-01-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3Ede%20Lorgeril%2C%20J.%2C%20Petton%2C%20B.%2C%20Lucasson%2C%20A.%2C%20Perez%2C%20V.%2C%20Stenger%2C%20P.-L.%2C%20Degremont%2C%20L.%2C%20Montagnani%2C%20C.%2C%20Escoubas%2C%20J.-M.%2C%20Haffner%2C%20P.%2C%20Allienne%2C%20J.-F.%2C%20Leroy%2C%20M.%2C%20Lagarde%2C%20F.%2C%20Vidal-Dupiol%2C%20J.%2C%20Gueguen%2C%20Y.%2C%20%26amp%3B%20Mitta%2C%20G.%20%282020%29.%20Differential%20basal%20expression%20of%20immune%20genes%20confers%20Crassostrea%20gigas%20resistance%20to%20Pacific%20oyster%20mortality%20syndrome.%20%3Ci%3EBmc%20Genomics%3C%5C%2Fi%3E%2C%20%3Ci%3E21%3C%5C%2Fi%3E%281%29%2C%2063.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12864-020-6471-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12864-020-6471-x%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DH9DEHIWN%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Differential%20basal%20expression%20of%20immune%20genes%20confers%20Crassostrea%20gigas%20resistance%20to%20Pacific%20oyster%20mortality%20syndrome%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aude%22%2C%22lastName%22%3A%22Lucasson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valerie%22%2C%22lastName%22%3A%22Perez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-Louis%22%2C%22lastName%22%3A%22Stenger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Haffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Francois%22%2C%22lastName%22%3A%22Allienne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franck%22%2C%22lastName%22%3A%22Lagarde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%5D%2C%22abstractNote%22%3A%22Background%20As%20a%20major%20threat%20to%20the%20oyster%20industry%2C%20Pacific%20Oyster%20Mortality%20Syndrome%20%28POMS%29%20is%20a%20polymicrobial%20disease%20affecting%20the%20main%20oyster%20species%20farmed%20across%20the%20world.%20POMS%20affects%20oyster%20juveniles%20and%20became%20panzootic%20this%20last%20decade%2C%20but%20POMS%20resistance%20in%20some%20oyster%20genotypes%20has%20emerged.%20While%20we%20know%20some%20genetic%20loci%20associated%20with%20resistance%2C%20the%20underlying%20mechanisms%20remained%20uncharacterized.%20So%2C%20we%20developed%20a%20comparative%20transcriptomic%20approach%20using%20basal%20gene%20expression%20profiles%20between%20different%20oyster%20biparental%20families%20with%20contrasted%20phenotypes%20when%20confronted%20to%20POMS%20%28resistant%20or%20susceptible%29.%20Results%20We%20showed%20that%20POMS%20resistant%20oysters%20show%20differential%20expression%20of%20genes%20involved%20in%20stress%20responses%2C%20protein%20modifications%2C%20maintenance%20of%20DNA%20integrity%20and%20repair%2C%20and%20immune%20and%20antiviral%20pathways.%20We%20found%20similarities%20and%20clear%20differences%20among%20different%20molecular%20pathways%20in%20the%20different%20resistant%20families.%20These%20results%20suggest%20that%20the%20resistance%20process%20is%20polygenic%20and%20partially%20varies%20according%20to%20the%20oyster%20genotype.%20Conclusions%20We%20found%20differences%20in%20basal%20expression%20levels%20of%20genes%20related%20to%20TLR-NF%20kappa%20B%2C%20JAK-STAT%20and%20STING-RLR%20pathways.%20These%20differences%20could%20explain%20the%20best%20antiviral%20response%2C%20as%20well%20as%20the%20robustness%20of%20resistant%20oysters%20when%20confronted%20to%20POMS.%20As%20some%20of%20these%20genes%20represent%20valuable%20candidates%20for%20selective%20breeding%2C%20we%20propose%20future%20studies%20should%20further%20examine%20their%20function.%22%2C%22date%22%3A%22JAN%2020%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12864-020-6471-x%22%2C%22ISSN%22%3A%221471-2164%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A13%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22DE4NZJV3%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Delmotte%20et%20al.%22%2C%22parsedDate%22%3A%222020-07-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDelmotte%2C%20J.%2C%20Chaparro%2C%20C.%2C%20Galinier%2C%20R.%2C%20de%20Lorgeril%2C%20J.%2C%20Petton%2C%20B.%2C%20Stenger%2C%20P.-L.%2C%20Vidal-Dupiol%2C%20J.%2C%20Destoumieux-Garzon%2C%20D.%2C%20Gueguen%2C%20Y.%2C%20Montagnani%2C%20C.%2C%20Escoubas%2C%20J.-M.%2C%20%26amp%3B%20Mitta%2C%20G.%20%282020%29.%20Contribution%20of%20Viral%20Genomic%20Diversity%20to%20Oyster%20Susceptibility%20in%20the%20Pacific%20Oyster%20Mortality%20Syndrome.%20%3Ci%3EFrontiers%20in%20Microbiology%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%2C%201579.%20https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00643%5C%2F75533%5C%2F.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2020.01579%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2020.01579%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DDE4NZJV3%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Contribution%20of%20Viral%20Genomic%20Diversity%20to%20Oyster%20Susceptibility%20in%20the%20Pacific%20Oyster%20Mortality%20Syndrome%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%22%2C%22lastName%22%3A%22Delmotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Galinier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre-Louis%22%2C%22lastName%22%3A%22Stenger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%5D%2C%22abstractNote%22%3A%22Juvenile%20Pacific%20oysters%20%28Crassostrea%20gigas%29%20are%20subjected%20to%20recurrent%20episodes%20of%20mass%20mortalities%20that%20constitute%20a%20threat%20for%20the%20oyster%20industry.%20This%20mortality%20syndrome%20named%20%5C%22Pacific%20Oyster%20Mortality%20Syndrome%5C%22%20%28POMS%29%20is%20a%20polymicrobial%20disease%20whose%20pathogenesis%20is%20initiated%20by%20a%20primary%20infection%20by%20a%20variant%20of%20an%20Ostreid%20herpes%20virus%20named%20OsHV-1%20mu%20Var.%20The%20characterization%20of%20the%20OsHV-1%20genome%20during%20different%20disease%20outbreaks%20occurring%20in%20different%20geographic%20areas%20has%20revealed%20the%20existence%20of%20a%20genomic%20diversity%20for%20OsHV-1%20mu%20Var.%20However%2C%20the%20biological%20significance%20of%20this%20diversity%20is%20still%20poorly%20understood.%20To%20go%20further%20in%20understanding%20the%20consequences%20of%20OsHV-1%20diversity%20on%20POMS%2C%20we%20challenged%20five%20biparental%20families%20of%20oysters%20to%20two%20different%20infectious%20environments%20on%20the%20French%20coasts%20%28Atlantic%20and%20Mediterranean%29.%20We%20observed%20that%20the%20susceptibility%20to%20POMS%20can%20be%20different%20among%20families%20within%20the%20same%20environment%20but%20also%20for%20the%20same%20family%20between%20the%20two%20environments.%20Viral%20diversity%20analysis%20revealed%20that%20Atlantic%20and%20Mediterranean%20POMS%20are%20caused%20by%20two%20distinct%20viral%20populations.%20Moreover%2C%20we%20observed%20that%20different%20oyster%20families%20are%20infected%20by%20distinct%20viral%20populations%20within%20a%20same%20infectious%20environment.%20Altogether%20these%20results%20suggest%20that%20the%20co-evolutionary%20processes%20at%20play%20between%20OsHV-1%20mu%20Var%20and%20oyster%20populations%20have%20selected%20a%20viral%20diversity%20that%20could%20facilitate%20the%20infection%20process%20and%20the%20transmission%20in%20oyster%20populations.%20These%20new%20data%20must%20be%20taken%20into%20account%20in%20the%20development%20of%20novel%20selective%20breeding%20programs%20better%20adapted%20to%20the%20oyster%20culture%20environment.%22%2C%22date%22%3A%22JUL%2010%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3389%5C%2Ffmicb.2020.01579%22%2C%22ISSN%22%3A%221664-302X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A10%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22L3VD225D%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lafont%20et%20al.%22%2C%22parsedDate%22%3A%222020-04%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELafont%2C%20M.%2C%20Vergnes%2C%20A.%2C%20Vidal-Dupiol%2C%20J.%2C%20de%20Lorgeril%2C%20J.%2C%20Gueguen%2C%20Y.%2C%20Haffner%2C%20P.%2C%20Petton%2C%20B.%2C%20Chaparro%2C%20C.%2C%20Barrachina%2C%20C.%2C%20Destoumieux-Garzon%2C%20D.%2C%20Mitta%2C%20G.%2C%20Gourbal%2C%20B.%2C%20%26amp%3B%20Montagnani%2C%20C.%20%282020%29.%20A%20Sustained%20Immune%20Response%20Supports%20Long-Term%20Antiviral%20Immune%20Priming%20in%20the%20Pacific%20Oyster%2C%20Crassostrea%20gigas.%20%3Ci%3EMbio%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%282%29%2C%20e02777-19.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FmBio.02777-19%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2FmBio.02777-19%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DL3VD225D%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20Sustained%20Immune%20Response%20Supports%20Long-Term%20Antiviral%20Immune%20Priming%20in%20the%20Pacific%20Oyster%2C%20Crassostrea%20gigas%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Lafont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%22%2C%22lastName%22%3A%22Vergnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Haffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Celia%22%2C%22lastName%22%3A%22Barrachina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Gourbal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%5D%2C%22abstractNote%22%3A%22Over%20the%20last%20decade%2C%20innate%20immune%20priming%20has%20been%20evidenced%20in%20many%20invertebrate%20phyla.%20If%20mechanistic%20models%20have%20been%20proposed%2C%20molecular%20studies%20aiming%20to%20substantiate%20these%20models%20have%20remained%20scarce.%20We%20reveal%20here%20the%20transcriptional%20signature%20associated%20with%20immune%20priming%20in%20the%20oyster%20Crassostrea%20gigas.%20Oysters%20were%20fully%20protected%20against%20Ostreid%20herpesvirus%201%20%28OsHV-1%29%2C%20a%20major%20oyster%20pathogen%2C%20after%20priming%20with%20poly%28I.C%29%2C%20which%20mimics%20viral%20double-stranded%20RNA.%20Global%20analysis%20through%20RNA%20sequencing%20of%20oyster%20and%20viral%20genes%20after%20immune%20priming%20and%20viral%20infection%20revealed%20that%20poly%28I.C%29%20induces%20a%20strong%20antiviral%20response%20that%20impairs%20OsHV-1%20replication.%20Protection%20is%20based%20on%20a%20sustained%20upregulation%20of%20immune%20genes%2C%20notably%20genes%20involved%20in%20the%20interferon%20pathway%20and%20apoptosis%2C%20which%20control%20subsequent%20viral%20infection.%20This%20persistent%20antiviral%20alert%20state%20remains%20active%20over%204%20months%20and%20supports%20antiviral%20protection%20in%20the%20long%20term.%20This%20acquired%20resistance%20mechanism%20reinforces%20the%20molecular%20foundations%20of%20the%20sustained%20response%20model%20of%20immune%20priming.%20It%20further%20opens%20the%20way%20to%20applications%20%28pseudovaccination%29%20to%20cope%20with%20a%20recurrent%20disease%20that%20causes%20dramatic%20economic%20losses%20in%20the%20shellfish%20farming%20industry%20worldwide.%20IMPORTANCE%20In%20the%20last%20decade%2C%20important%20discoveries%20have%20shown%20that%20resistance%20to%20reinfection%20can%20be%20achieved%20without%20a%20functional%20adaptive%20immune%20system%2C%20introducing%20the%20concept%20of%20innate%20immune%20memory%20in%20invertebrates.%20However%2C%20this%20field%20has%20been%20constrained%20by%20the%20limited%20number%20of%20molecular%20mechanisms%20evidenced%20to%20support%20these%20phenomena.%20Taking%20advantage%20of%20an%20invertebrate%20species%2C%20the%20Pacific%20oyster%20%28Crassostrea%20gigas%29%2C%20in%20which%20we%20evidenced%20one%20of%20the%20longest%20and%20most%20effective%20periods%20of%20protection%20against%20viral%20infection%20observed%20in%20an%20invertebrate%2C%20we%20provide%20the%20first%20comprehensive%20transcriptomic%20analysis%20of%20antiviral%20innate%20immune%20priming.%20We%20show%20that%20priming%20with%20poly%28I.C%29%20induced%20a%20massive%20upregulation%20of%20immune-related%20genes%2C%20which%20control%20subsequent%20viral%20infection%2C%20and%20it%20was%20maintained%20for%20over%204%20months%20after%20priming.%20This%20acquired%20resistant%20mechanism%20reinforces%20the%20molecular%20foundations%20of%20the%20sustained%20response%20model%20of%20immune%20priming.%20It%20opens%20the%20way%20to%20pseudovaccination%20to%20prevent%20the%20recurrent%20diseases%20that%20currently%20afflict%20economically%20or%20ecologically%20important%20invertebrates.%22%2C%22date%22%3A%22MAR-APR%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1128%5C%2FmBio.02777-19%22%2C%22ISSN%22%3A%222150-7511%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fmbio.asm.org%5C%2Fcontent%5C%2F11%5C%2F2%5C%2Fe02777-19%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A04%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22BRWV2LHF%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Le%20Franc%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELe%20Franc%2C%20L.%2C%20Bernay%2C%20B.%2C%20Petton%2C%20B.%2C%20Since%2C%20M.%2C%20Favrel%2C%20P.%2C%20%26amp%3B%20Riviere%2C%20G.%20%282020%29.%20A%20functional%20m%286%29A-RNA%20methylation%20pathway%20in%20the%20oysterCrassostrea%20gigasassumes%20epitranscriptomic%20regulation%20of%20lophotrochozoan%20development.%20%3Ci%3EFebs%20Journal%3C%5C%2Fi%3E%2C%20%3Ci%3EEarly%20virw%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ffebs.15500%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ffebs.15500%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DBRWV2LHF%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20functional%20m%286%29A-RNA%20methylation%20pathway%20in%20the%20oysterCrassostrea%20gigasassumes%20epitranscriptomic%20regulation%20of%20lophotrochozoan%20development%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorane%22%2C%22lastName%22%3A%22Le%20Franc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%22%2C%22lastName%22%3A%22Bernay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Since%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Favrel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Riviere%22%7D%5D%2C%22abstractNote%22%3A%22N-6-methyladenosine%20%28m%286%29A%29%20is%20a%20prevalent%20epitranscriptomic%20mark%20in%20eukaryotic%20RNA%2C%20with%20crucial%20roles%20for%20mammalian%20and%20ecdysozoan%20development.%20Indeed%2C%20m%286%29A-RNA%20and%20the%20related%20protein%20machinery%20are%20important%20for%20splicing%2C%20translation%2C%20maternal-to-zygotic%20transition%20and%20cell%20differentiation.%20However%2C%20to%20date%2C%20the%20presence%20of%20an%20m%286%29A-RNA%20pathway%20remains%20unknown%20in%20more%20distant%20animals%2C%20questioning%20the%20evolution%20and%20significance%20of%20the%20epitranscriptomic%20regulation.%20Therefore%2C%20we%20investigated%20the%20m%286%29A-RNA%20pathway%20in%20the%20oysterCrassostrea%20gigas%2C%20a%20lophotrochozoan%20model%20whose%20development%20was%20demonstrated%20under%20strong%20epigenetic%20influence.%20Using%20mass%20spectrometry%20and%20dot%20blot%20assays%2C%20we%20demonstrated%20that%20m%286%29A-RNA%20is%20actually%20present%20in%20the%20oyster%20and%20displays%20variations%20throughout%20early%20oyster%20development%2C%20with%20the%20lowest%20levels%20at%20the%20end%20of%20cleavage.%20In%20parallel%2C%20byin%20silicoanalyses%2C%20we%20were%20able%20to%20characterize%20at%20the%20molecular%20level%20a%20complete%20and%20conserved%20putative%20m%286%29A%20machinery.%20The%20expression%20levels%20of%20the%20identified%20putative%20m%286%29A%20writers%2C%20erasers%20and%20readers%20were%20strongly%20regulated%20across%20oyster%20development.%20Finally%2C%20RNA%20pull-down%20coupled%20to%20LC-MS%5C%2FMS%20allowed%20us%20to%20prove%20the%20actual%20presence%20of%20readers%20able%20to%20bind%20m%286%29A-RNA%20and%20exhibiting%20specific%20developmental%20patterns.%20Altogether%2C%20our%20results%20demonstrate%20the%20conservation%20of%20a%20complete%20m%286%29A-RNA%20pathway%20in%20the%20oyster%20and%20strongly%20suggest%20its%20implication%20in%20early%20developmental%20processes%20including%20MZT.%20This%20first%20demonstration%20and%20characterization%20of%20an%20epitranscriptomic%20regulation%20in%20a%20lophotrochozoan%20model%2C%20potentially%20involved%20in%20the%20embryogenesis%2C%20bring%20new%20insights%20into%20our%20understanding%20of%20developmental%20epigenetic%20processes%20and%20their%20evolution.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1111%5C%2Ffebs.15500%22%2C%22ISSN%22%3A%221742-464X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-05-29T17%3A03%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22D6UJTEG2%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Trotter%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETrotter%2C%20A.%20J.%2C%20Vignier%2C%20J.%2C%20Wilson%2C%20T.%20K.%2C%20Douglas%2C%20M.%2C%20Adams%2C%20S.%20L.%2C%20King%2C%20N.%2C%20Cunningham%2C%20M.%20P.%2C%20Carter%2C%20C.%20G.%2C%20Boudry%2C%20P.%2C%20Petton%2C%20B.%2C%20Degremont%2C%20L.%2C%20Smith%2C%20G.%20G.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282021%29.%20Case%20study%20of%20vertical%20transmission%20of%20ostreid%20herpesvirus-1%20in%20Pacific%20oysters%20and%20biosecurity%20management%20based%20on%20epidemiological%20data%20from%20French%2C%20New%20Zealand%20and%20Australian%20hatchery-propagated%20seed.%20%3Ci%3EAquaculture%20Research%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fare.15219%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fare.15219%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DD6UJTEG2%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Case%20study%20of%20vertical%20transmission%20of%20ostreid%20herpesvirus-1%20in%20Pacific%20oysters%20and%20biosecurity%20management%20based%20on%20epidemiological%20data%20from%20French%2C%20New%20Zealand%20and%20Australian%20hatchery-propagated%20seed%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20J.%22%2C%22lastName%22%3A%22Trotter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Vignier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Teresa%20K.%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Douglas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Serean%20L.%22%2C%22lastName%22%3A%22Adams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nick%22%2C%22lastName%22%3A%22King%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20P.%22%2C%22lastName%22%3A%22Cunningham%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%20G.%22%2C%22lastName%22%3A%22Carter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Boudry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Greg%20G.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1111%5C%2Fare.15219%22%2C%22ISSN%22%3A%221355-557X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22PCQMC87R%22%5D%2C%22dateModified%22%3A%222021-05-29T16%3A28%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22LEADL3DY%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tallec%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-21%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETallec%2C%20K.%2C%20Paul-Pont%2C%20I.%2C%20Petton%2C%20B.%2C%20Alunno-Bruscia%2C%20M.%2C%20Bourdon%2C%20C.%2C%20Bernardini%2C%20I.%2C%20Boulais%2C%20M.%2C%20Lambert%2C%20C.%2C%20Quere%2C%20C.%2C%20Bideau%2C%20A.%2C%20Le%20Goic%2C%20N.%2C%20Cassone%2C%20A.-L.%2C%20Le%20Grand%2C%20F.%2C%20Fabioux%2C%20C.%2C%20Soudant%2C%20P.%2C%20%26amp%3B%20Huvet%2C%20A.%20%282021%29.%20Amino-nanopolystyrene%20exposures%20of%20oyster%20%28Crassostrea%20gigas%29%20embryos%20induced%20no%20apparent%20intergenerational%20effects.%20%3Ci%3ENanotoxicology%3C%5C%2Fi%3E%2C%20%3Ci%3E15%3C%5C%2Fi%3E%284%29%2C%20477%26%23x2013%3B493.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F17435390.2021.1879963%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F17435390.2021.1879963%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DLEADL3DY%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Amino-nanopolystyrene%20exposures%20of%20oyster%20%28Crassostrea%20gigas%29%20embryos%20induced%20no%20apparent%20intergenerational%20effects%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Tallec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Paul-Pont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Alunno-Bruscia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Bourdon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%22%2C%22lastName%22%3A%22Bernardini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Boulais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Quere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Bideau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Le%20Goic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.-L.%22%2C%22lastName%22%3A%22Cassone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Le%20Grand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Fabioux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Soudant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Huvet%22%7D%5D%2C%22abstractNote%22%3A%22Early%20life%20stages%20%28ELS%29%20of%20numerous%20marine%20invertebrates%20mustcope%20with%20man-made%20contaminants%2C%20including%20plastic%20debris%2C%20during%20their%20pelagic%20phase.%20Among%20the%20diversity%20of%20plastic%20particles%2C%20nano-sized%20debris%2C%20known%20as%20nanoplastics%2C%20can%20induce%20effects%20with%20severe%20outcomes%20in%20ELS%20of%20various%20biological%20models%2C%20including%20the%20Pacific%20oyster%20Crassostrea%20gigas.%20Here%2C%20we%20investigated%20the%20effects%20of%20a%20sub-lethal%20dose%20%280.1%20mu%20g%20mL%28-1%29%29%20of%2050%20nm%20polystyrene%20nanobeads%20%28nano-PS%29%20with%20amine%20functions%20on%20oyster%20embryos%20%2824%20h%20exposure%29%20and%20we%20assessed%20consequences%20on%20larval%20and%20adult%20performances%20over%20two%20generations%20of%20oysters.%20Only%20a%20few%20effects%20were%20observed.%20Lipid%20analyses%20revealed%20that%20first-generation%20%28G1%29%20embryos%20exposed%20to%20nano-PS%20displayed%20a%20relative%20increase%20in%20cardiolipin%20content%20%28%2B9.7%25%29%2C%20suggesting%20a%20potential%20modification%20of%20mitochondrial%20functioning.%20G1-larvae%20issued%20from%20exposed%20embryos%20showed%20decreases%20in%20larval%20growth%20%28-9%25%29%20and%20lipid%20storage%20%28-20%25%29.%20No%20effect%20was%20observed%20at%20the%20G1%20adult%20stage%20in%20terms%20of%20growth%2C%20ecophysiological%20parameters%20%28clearance%20and%20respiration%20rates%2C%20absorption%20efficiency%29%2C%20or%20reproductive%20outputs%20%28gonadic%20development%2C%20gamete%20quality%29.%20Second%20generation%20%28G2%29%20larvae%20issued%20from%20control%20G1%20displayed%20a%20significant%20growth%20reduction%20after%20G2%20embryonic%20exposure%20to%20nano-PS%20%28-24%25%29%20compared%20to%20control%20%28as%20observed%20at%20the%20first%20generation%29%2C%20while%20no%20intergenerational%20effect%20was%20detected%20on%20G2%20larvae%20issued%20from%20G1%20exposed%20embryos.%20Overall%2C%20the%20present%20experimental%20study%20suggests%20a%20low%20incidence%20of%20a%20short%20embryonic%20exposure%20to%20nano-PS%20on%20oyster%20phenotypes%20along%20the%20entire%20life%20cycle%20until%20the%20next%20larval%20generation.%22%2C%22date%22%3A%22APR%2021%202021%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1080%5C%2F17435390.2021.1879963%22%2C%22ISSN%22%3A%221743-5390%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22PCQMC87R%22%5D%2C%22dateModified%22%3A%222021-05-29T16%3A28%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22YJC3GK42%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lupo%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELupo%2C%20C.%2C%20Dutta%2C%20B.%20L.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Ezanna%2C%20P.%2C%20Tourbiez%2C%20D.%2C%20Travers%2C%20M.-A.%2C%20Pernet%2C%20F.%2C%20%26amp%3B%20Bacher%2C%20C.%20%282020%29.%20Spatial%20epidemiological%20modelling%20of%20infection%20by%20Vibrio%20aestuarianus%20shows%20that%20connectivity%20and%20temperature%20control%20oyster%20mortality.%20%3Ci%3EAquaculture%20Environment%20Interactions%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%2C%20511%26%23x2013%3B527.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Faei00379%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Faei00379%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DYJC3GK42%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Spatial%20epidemiological%20modelling%20of%20infection%20by%20Vibrio%20aestuarianus%20shows%20that%20connectivity%20and%20temperature%20control%20oyster%20mortality%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Coralie%22%2C%22lastName%22%3A%22Lupo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bhagat%20Lal%22%2C%22lastName%22%3A%22Dutta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%22%2C%22lastName%22%3A%22Ezanna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Tourbiez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Agnes%22%2C%22lastName%22%3A%22Travers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cedric%22%2C%22lastName%22%3A%22Bacher%22%7D%5D%2C%22abstractNote%22%3A%22Vibrio%20aestuarianus%20infection%20in%20oyster%20populations%20causes%20massive%20mortality%2C%20resulting%20in%20losses%20for%20oyster%20farmers.%20Such%20dynamics%20result%20from%20host-pathogen%20interactions%20and%20contagion%20through%20water-borne%20transmission.%20To%20assess%20the%20spatiotemporal%20spread%20of%20V.%20aestuarianus%20infection%20and%20associated%20oyster%20mortality%20at%20a%20bay%20scale%2C%20we%20built%20a%20mathematical%20model%20informed%20by%20experimental%20infection%20data%20at%202%20temperatures%20and%20spatially%20dependent%20marine%20connectivity%20of%20oyster%20farms.%20We%20applied%20the%20model%20to%20a%20real%20system%20and%20tested%20the%20importance%20of%20each%20factor%20using%20a%20number%20of%20modelling%20scenarios.%20Results%20suggest%20that%20introducing%20V.%20aestuarianus%20in%20a%20fully%20susceptible%20adult%20oyster%20population%20in%20the%20bay%20would%20lead%20to%20the%20mortality%20of%20all%20farmed%20oysters%20over%206%20to%2012%20mo%2C%20depending%20on%20the%20location%20in%20which%20infection%20was%20initiated.%20The%20effect%20of%20temperature%20was%20captured%20by%20the%20basic%20reproduction%20number%20%28R-0%29%2C%20which%20was%20%3E1%20at%20high%20seawater%20temperatures%2C%20as%20opposed%20to%20values%20%3C1%20at%20low%20temperatures.%20At%20the%20ecosystem%20scale%2C%20simulations%20showed%20the%20existence%20of%20long-distance%20dispersal%20of%20free-living%20bacteria.%20The%20western%20part%20of%20the%20bay%20could%20be%20reached%20by%20bacteria%20originating%20from%20the%20eastern%20side%2C%20though%20the%20spread%20time%20was%20greatly%20increased.%20Further%20developments%20of%20the%20model%2C%20including%20the%20consideration%20of%20the%20anthropogenic%20movements%20of%20oysters%20and%20oyster-specific%20sensitivity%20factors%2C%20would%20allow%20the%20development%20of%20accurate%20maps%20of%20epidemiological%20risks%20and%20help%20define%20aquaculture%20zoning.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3354%5C%2Faei00379%22%2C%22ISSN%22%3A%221869-215X%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-03-31T14%3A04%3A45Z%22%7D%7D%2C%7B%22key%22%3A%229DR5IR7Q%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Delisle%20et%20al.%22%2C%22parsedDate%22%3A%222020-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDelisle%2C%20L.%2C%20Pauletto%2C%20M.%2C%20Vidal-Dupiol%2C%20J.%2C%20Petton%2C%20B.%2C%20Bargelloni%2C%20L.%2C%20Montagnani%2C%20C.%2C%20Pernet%2C%20F.%2C%20Corporeau%2C%20C.%2C%20%26amp%3B%20Fleury%2C%20E.%20%282020%29.%20High%20temperature%20induces%20transcriptomic%20changes%20in%20Crassostrea%20gigas%20that%20hinder%20progress%20of%20ostreid%20herpesvirus%20%28OsHV-1%29%20and%20promote%20survival.%20%3Ci%3EJournal%20of%20Experimental%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E223%3C%5C%2Fi%3E%2820%29%2C%20jeb226233.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1242%5C%2Fjeb.226233%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1242%5C%2Fjeb.226233%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D9DR5IR7Q%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20temperature%20induces%20transcriptomic%20changes%20in%20Crassostrea%20gigas%20that%20hinder%20progress%20of%20ostreid%20herpesvirus%20%28OsHV-1%29%20and%20promote%20survival%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lizenn%22%2C%22lastName%22%3A%22Delisle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianna%22%2C%22lastName%22%3A%22Pauletto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luca%22%2C%22lastName%22%3A%22Bargelloni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Corporeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%5D%2C%22abstractNote%22%3A%22Of%20all%20environmental%20factors%2C%20seawater%20temperature%20plays%20a%20decisive%20role%20in%20triggering%20marine%20diseases.%20Like%20fever%20in%20vertebrates%2C%20high%20seawater%20temperature%20could%20modulate%20the%20host%20response%20to%20pathogens%20in%20ectothermic%20animals.%20In%20France%2C%20massive%20mortality%20of%20Pacific%20oysters%2C%20Crassostrea%20gigas%2C%20caused%20by%20the%20ostreid%20herpesvirus%201%20%28OsHV-1%29%20is%20markedly%20reduced%20when%20temperatures%20exceed%2024%20degrees%20C%20in%20the%20field.%20In%20the%20present%20study%20we%20assess%20how%20high%20temperature%20influences%20the%20host%20response%20to%20the%20pathogen%20by%20comparing%20transcriptomes%20%28RNA%20sequencing%29%20during%20the%20course%20of%20experimental%20infection%20at%2021%20degrees%20C%20%28reference%29%20and%2029%20degrees%20C.%20We%20show%20that%20high%20temperature%20induced%20host%20physiological%20processes%20that%20are%20unfavorable%20to%20the%20viral%20infection.%20Temperature%20influenced%20the%20expression%20of%20transcripts%20related%20to%20the%20immune%20process%20and%20increased%20the%20transcription%20of%20genes%20related%20to%20the%20apoptotic%20process%2C%20synaptic%20signaling%20and%20protein%20processes%20at%2029%20degrees%20C.%20Concomitantly%2C%20the%20expression%20of%20genes%20associated%20with%20catabolism%2C%20metabolite%20transport%2C%20macromolecule%20synthesis%20and%20cell%20growth%20remained%20low%20from%20the%20first%20stage%20of%20infection%20at%2029%20degrees%20C.%20Moreover%2C%20viral%20entry%20into%20the%20host%20might%20have%20been%20limited%20at%2029%20degrees%20C%20by%20changes%20in%20extracellular%20matrix%20composition%20and%20protein%20abundance.%20Overall%2C%20these%20results%20provide%20new%20insights%20into%20how%20environmental%20factors%20modulate%20host-pathogen%20interactions.%22%2C%22date%22%3A%22OCT%202020%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1242%5C%2Fjeb.226233%22%2C%22ISSN%22%3A%220022-0949%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22Y5CNVM8Y%22%5D%2C%22dateModified%22%3A%222021-03-31T13%3A53%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22T6MJPJPQ%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Piel%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPiel%2C%20D.%2C%20Bruto%2C%20M.%2C%20James%2C%20A.%2C%20Labreuche%2C%20Y.%2C%20Lambert%2C%20C.%2C%20Janicot%2C%20A.%2C%20Chenivesse%2C%20S.%2C%20Petton%2C%20B.%2C%20Wegner%2C%20K.%20M.%2C%20Stoudmann%2C%20C.%2C%20Blokesch%2C%20M.%2C%20%26amp%3B%20Le%20Roux%2C%20F.%20%282019%29.%20Selection%20of%20Vibrio%20crassostreae%20relies%20on%20a%20plasmid%20expressing%20a%20type%206%20secretion%20system%20cytotoxic%20for%20host%20immune%20cells.%20%3Ci%3EEnvironmental%20Microbiology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1462-2920.14776%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2F1462-2920.14776%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DT6MJPJPQ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Selection%20of%20Vibrio%20crassostreae%20relies%20on%20a%20plasmid%20expressing%20a%20type%206%20secretion%20system%20cytotoxic%20for%20host%20immune%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Piel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Bruto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adele%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Labreuche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Janicot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Chenivesse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20Mathias%22%2C%22lastName%22%3A%22Wegner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Candice%22%2C%22lastName%22%3A%22Stoudmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Blokesch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%5D%2C%22abstractNote%22%3A%22Pacific%20oyster%20mortality%20syndrome%20affects%20juveniles%20of%20Crassostrea%20gigas%20oysters%20and%20threatens%20the%20sustainability%20of%20commercial%20and%20natural%20stocks%20of%20this%20species.%20Vibrio%20crassostreae%20%28V.%20crassostreae%29%20has%20been%20repeatedly%20isolated%20from%20diseased%20animals%2C%20and%20the%20majority%20of%20the%20strains%20have%20been%20demonstrated%20to%20be%20virulent%20for%20oysters.%20In%20this%20study%2C%20we%20showed%20that%20oyster%20farms%20exhibited%20a%20high%20prevalence%20of%20a%20virulence%20plasmid%20carried%20by%20V.%20crassostreae%2C%20while%20oysters%2C%20at%20an%20adult%20stage%2C%20were%20reservoirs%20of%20this%20virulent%20population.%20The%20pathogenicity%20of%20V.%20crassostreae%20depends%20on%20a%20novel%20transcriptional%20regulator%2C%20which%20activates%20the%20bidirectional%20promoter%20of%20a%20type%206%20secretion%20system%20%28T6SS%29%20genes%20cluster.%20Both%20the%20T6SS%20and%20a%20second%20chromosomal%20virulence%20factor%2C%20r5.7%2C%20are%20necessary%20for%20virulence%20but%20act%20independently%20to%20cause%20haemocyte%20%28oyster%20immune%20cell%29%20cytotoxicity.%20A%20phylogenetically%20closely%20related%20T6SS%20was%20identified%20in%20V.%20aestuarianus%20and%20V.%20tapetis%2C%20which%20infect%20adult%20oysters%20and%20clams%20respectively.%20We%20propose%20that%20haemocyte%20cytotoxicity%20is%20a%20lethality%20trait%20shared%20by%20a%20broad%20range%20of%20mollusc%20pathogens%2C%20and%20we%20speculate%20that%20T6SS%20was%20involved%20in%20parallel%20evolution%20of%20pathogen%20for%20molluscs.%22%2C%22date%22%3A%222019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1111%5C%2F1462-2920.14776%22%2C%22ISSN%22%3A%221462-2912%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2F1462-2920.14776%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A58%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22C7C3BHP3%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gangnery%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGangnery%2C%20A.%2C%20Normand%2C%20J.%2C%20Duval%2C%20C.%2C%20Cugier%2C%20P.%2C%20Grangere%2C%20K.%2C%20Petton%2C%20B.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Orvain%2C%20F.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282019%29.%20Connectivities%20with%20shellfish%20farms%20and%20channel%20rivers%20are%20associated%20with%20mortality%20risk%20in%20oysters.%20%3Ci%3EAquaculture%20Environment%20Interactions%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%2C%20493%26%23x2013%3B506.%20https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00588%5C%2F69983%5C%2F.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Faei00327%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Faei00327%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DC7C3BHP3%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Connectivities%20with%20shellfish%20farms%20and%20channel%20rivers%20are%20associated%20with%20mortality%20risk%20in%20oysters%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aline%22%2C%22lastName%22%3A%22Gangnery%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Normand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cyrielle%22%2C%22lastName%22%3A%22Duval%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Cugier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karine%22%2C%22lastName%22%3A%22Grangere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francis%22%2C%22lastName%22%3A%22Orvain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22Oyster%20diseases%20have%20major%20consequences%20on%20fisheries%20and%20aquaculture.%20In%20France%2C%20young%20Pacific%20oysters%20Crassostrea%20gigas%20are%20severely%20hit%20by%20the%20ostreid%20herpesvirus%2C%20whereas%20adults%20suffer%20mortalities%20presumably%20caused%20by%20pathogenic%20bacteria.%20Here%20we%20investigated%20the%20origin%20and%20spread%20of%20mortalities%20that%20affect%20both%20young%20and%20adult%20oysters%2C%20and%20we%20identified%20and%20compared%20their%20risk%20factors.%20Mortality%20was%20monitored%20in%202%20age%20classes%20of%20oysters%20deployed%20in%20early%20spring%20at%2039%20sites%20spread%20over%20a%2037%20km%282%29%20surface%20area%20inside%20and%20outside%20of%20shellfish%20farms.%20Environmental%20data%20obtained%20from%20numerical%20modelling%20were%20used%20to%20investigate%20risk%20factors.%20Mortality%20of%20young%20oysters%20associated%20with%20ostreid%20herpesvirus%20occurred%20in%20the%20oyster%20farming%20area.%20Hydrodynamic%20connectivity%20with%20oyster%20farms%20was%20associated%20with%20higher%20mortality%20risk%2C%20whereas%20chlorophyll%20a%20concentration%20was%20associated%20with%20a%20lower%20risk.%20Adult%20oysters%20experienced%202%20mortality%20events%20that%20were%20associated%20with%20different%20risk%20factors.%20The%20first%20event%2C%20which%20occurred%20after%20deployment%20and%20was%20probably%20caused%20by%20endogenous%20pathogens%2C%20was%20mainly%20associated%20with%20connectivity%20to%20channel%20rivers%20and%20salinity.%20The%20second%20mortality%20event%20observed%20at%20the%20end%20of%20the%20summer%20was%20mainly%20associated%20with%20connectivity%20to%20oyster%20farms%2C%20suggesting%20pathogen%20transmission.%20The%20risk%20factors%20involved%20in%20young%20and%20adult%20oyster%20mortalities%20were%20partly%20different%2C%20reflecting%20distinct%20origins.%20Connectivity%20with%20oyster%20farms%20is%20a%20mortality%20risk%20factor%20for%20both%20young%20and%20adult%20oysters%3B%20thus%2C%20disease%20management%20strategies%20that%20focus%20on%20oyster%20farming%20areas%20will%20impact%20overall%20disease%20risk.%22%2C%22date%22%3A%222019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3354%5C%2Faei00327%22%2C%22ISSN%22%3A%221869-215X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.int-res.com%5C%2Fabstracts%5C%2Faei%5C%2Fv11%5C%2Fp493-506%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A57%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22US6ZFV7I%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rubio%20et%20al.%22%2C%22parsedDate%22%3A%222019-07-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERubio%2C%20T.%2C%20Oyanedel%2C%20D.%2C%20Labreuche%2C%20Y.%2C%20Toulza%2C%20E.%2C%20Luo%2C%20X.%2C%20Bruto%2C%20M.%2C%20Chaparro%2C%20C.%2C%20Torres%2C%20M.%2C%20de%20Lorgeril%2C%20J.%2C%20Haffner%2C%20P.%2C%20Vidal-Dupiol%2C%20J.%2C%20Lagorce%2C%20A.%2C%20Petton%2C%20B.%2C%20Mitta%2C%20G.%2C%20Jacq%2C%20A.%2C%20Le%20Roux%2C%20F.%2C%20Charriere%2C%20G.%20M.%2C%20%26amp%3B%20Destoumieux-Garzon%2C%20D.%20%282019%29.%20Species-specific%20mechanisms%20of%20cytotoxicity%20toward%20immune%20cells%20determine%20the%20successful%20outcome%20of%20Vibrio%20infections.%20%3Ci%3EProceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America%3C%5C%2Fi%3E%2C%20%3Ci%3E116%3C%5C%2Fi%3E%2828%29%2C%2014238%26%23x2013%3B14247.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.1905747116%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.1905747116%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DUS6ZFV7I%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Species-specific%20mechanisms%20of%20cytotoxicity%20toward%20immune%20cells%20determine%20the%20successful%20outcome%20of%20Vibrio%20infections%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tristan%22%2C%22lastName%22%3A%22Rubio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Oyanedel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Labreuche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xing%22%2C%22lastName%22%3A%22Luo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Bruto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marta%22%2C%22lastName%22%3A%22Torres%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Haffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Lagorce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annick%22%2C%22lastName%22%3A%22Jacq%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%20M.%22%2C%22lastName%22%3A%22Charriere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%5D%2C%22abstractNote%22%3A%22Vibrio%20species%20cause%20infectious%20diseases%20in%20humans%20and%20animals%2C%20but%20they%20can%20also%20live%20as%20commensals%20within%20their%20host%20tissues.%20How%20Vibrio%20subverts%20the%20host%20defenses%20to%20mount%20a%20successful%20infection%20remains%20poorly%20understood%2C%20and%20this%20knowledge%20is%20critical%20for%20predicting%20and%20managing%20disease.%20Here%2C%20we%20have%20investigated%20the%20cellular%20and%20molecular%20mechanisms%20underpinning%20infection%20and%20colonization%20of%202%20virulent%20Vibrio%20species%20in%20an%20ecologically%20relevant%20host%20model%2C%20oyster%2C%20to%20study%20interactions%20with%20marine%20Vibrio%20species.%20All%20Vibrio%20strains%20were%20recognized%20by%20the%20immune%20system%2C%20but%20only%20nonvirulent%20strains%20were%20controlled.%20We%20showed%20that%20virulent%20strains%20were%20cytotoxic%20to%20hemocytes%2C%20oyster%20immune%20cells.%20By%20analyzing%20host%20and%20bacterial%20transcriptional%20responses%20to%20infection%2C%20together%20with%20Vibrio%20gene%20knock-outs%2C%20we%20discovered%20that%20Vibrio%20crassostreae%20and%20Vibrio%20tasmaniensis%20use%20distinct%20mechanisms%20to%20cause%20hemocyte%20lysis.%20Whereas%20V.%20crassostreae%20cytotoxicity%20is%20dependent%20on%20a%20direct%20contact%20with%20hemocytes%20and%20requires%20an%20ancestral%20gene%20encoding%20a%20protein%20of%20unknown%20function%2C%20r5.7%2C%20V.%20tasmaniensis%20cytotoxicity%20is%20dependent%20on%20phagocytosis%20and%20requires%20intracellular%20secretion%20of%20T6SS%20effectors.%20We%20conclude%20that%20proliferation%20of%20commensal%20vibrios%20is%20controlled%20by%20the%20host%20immune%20system%2C%20preventing%20systemic%20infections%20in%20oysters%2C%20whereas%20the%20successful%20infection%20of%20virulent%20strains%20relies%20on%20Vibrio%20species-specific%20molecular%20determinants%20that%20converge%20to%20compromise%20host%20immune%20cell%20function%2C%20allowing%20evasion%20of%20the%20host%20immune%20system.%22%2C%22date%22%3A%22JUL%209%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.1905747116%22%2C%22ISSN%22%3A%220027-8424%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00507%5C%2F61837%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A57%3A21Z%22%7D%7D%2C%7B%22key%22%3A%229N7E3EHR%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pernet%20et%20al.%22%2C%22parsedDate%22%3A%222019-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPernet%2C%20F.%2C%20Tamayo%2C%20D.%2C%20Fuhrmann%2C%20M.%2C%20%26amp%3B%20Petton%2C%20B.%20%282019%29.%20Deciphering%20the%20effect%20of%20food%20availability%2C%20growth%20and%20host%20condition%20on%20disease%20susceptibility%20in%20a%20marine%20invertebrate.%20%3Ci%3EJournal%20of%20Experimental%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E222%3C%5C%2Fi%3E%2817%29%2C%20UNSP%20jeb210534.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1242%5C%2Fjeb.210534%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1242%5C%2Fjeb.210534%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D9N7E3EHR%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deciphering%20the%20effect%20of%20food%20availability%2C%20growth%20and%20host%20condition%20on%20disease%20susceptibility%20in%20a%20marine%20invertebrate%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Tamayo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Fuhrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%5D%2C%22abstractNote%22%3A%22Food%20provisioning%20influences%20disease%20risk%20and%20outcome%20in%20animal%20populations%20in%20two%20ways.%20On%20the%20one%20hand%2C%20unrestricted%20food%20supply%20improves%20the%20physiological%20condition%20of%20the%20host%20and%20lowers%20its%20susceptibility%20to%20infectious%20disease%2C%20reflecting%20a%20trade-off%20between%20immunity%20and%20other%20fitness-related%20functions.%20On%20the%20other%20hand%2C%20food%20scarcity%20limits%20the%20resources%20available%20to%20the%20pathogen%20and%20slows%20the%20growth%20and%20metabolism%20of%20the%20host%20on%20which%20the%20pathogen%20depends%20to%20proliferate.%20Here%2C%20we%20investigated%20how%20food%20availability%2C%20growth%20rate%20and%20energetic%20reserves%20drive%20the%20outcome%20of%20a%20viral%20disease%20affecting%20an%20ecologically%20relevant%20model%20host%2C%20the%20Pacific%20oyster%2C%20Crassostrea%20gigas.%20We%20selected%20fast-%20and%20slow-growing%20animals%2C%20and%20we%20exposed%20them%20to%20high%20and%20low%20food%20rations.%20We%20evaluated%20their%20energetic%20reserves%2C%20challenged%20them%20with%20a%20pathogenic%20virus%2C%20monitored%20daily%20survival%20and%20developed%20a%20mortality%20risk%20model.%20Although%20high%20food%20levels%20and%20oyster%20growth%20were%20associated%20with%20a%20higher%20risk%20of%20mortality%2C%20energy%20reserves%20were%20associated%20with%20a%20lower%20risk.%20Food%20availability%20acts%20both%20as%20an%20enabling%20factor%20for%20mortality%20by%20increasing%20oyster%20growth%20and%20as%20a%20limiting%20factor%20by%20increasing%20their%20energy%20reserves.%20This%20study%20clarifies%20how%20food%20resources%20have%20an%20impact%20on%20susceptibility%20to%20disease%20and%20indicates%20how%20the%20host%27s%20physiological%20condition%20could%20mitigate%20epidemics.%20Practically%2C%20we%20suggest%20that%20growth%20should%20be%20optimized%20rather%20than%20maximized%2C%20considering%20that%20trade-offs%20occur%20with%20disease%20resistance%20or%20tolerance.%22%2C%22date%22%3A%22SEP%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1242%5C%2Fjeb.210534%22%2C%22ISSN%22%3A%220022-0949%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjeb.biologists.org%5C%2Fcontent%5C%2Fjexbio%5C%2F222%5C%2F17%5C%2Fjeb210534.full.pdf%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A57%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22WDHHVU5P%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pernet%20et%20al.%22%2C%22parsedDate%22%3A%222019-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPernet%2C%20F.%2C%20Gachelin%2C%20S.%2C%20Stanisiere%2C%20J.-Y.%2C%20Petton%2C%20B.%2C%20Fleury%2C%20E.%2C%20%26amp%3B%20Mazurie%2C%20J.%20%282019%29.%20Farmer%20monitoring%20reveals%20the%20effect%20of%20tidal%20height%20on%20mortality%20risk%20of%20oysters%20during%20a%20herpesvirus%20outbreak.%20%3Ci%3EICES%20Journal%20of%20Marine%20Science%3C%5C%2Fi%3E%2C%20%3Ci%3E76%3C%5C%2Fi%3E%286%29%2C%201816%26%23x2013%3B1824.%20https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00491%5C%2F60271%5C%2F.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Ficesjms%5C%2Ffsz074%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Ficesjms%5C%2Ffsz074%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DWDHHVU5P%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Farmer%20monitoring%20reveals%20the%20effect%20of%20tidal%20height%20on%20mortality%20risk%20of%20oysters%20during%20a%20herpesvirus%20outbreak%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonia%22%2C%22lastName%22%3A%22Gachelin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Yves%22%2C%22lastName%22%3A%22Stanisiere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Mazurie%22%7D%5D%2C%22abstractNote%22%3A%22The%20intertidal%20zone%20is%20characterized%20by%20a%20sharp%20vertical%20gradient%20of%20environmental%20stress%2C%20which%20structures%20species%20distribution%20and%20their%20interactions.%20Few%20studies%2C%20however%2C%20have%20examined%20the%20influence%20of%20tidal%20height%20on%20host-pathogen%20interactions.%20Here%2C%20we%20investigated%20how%20the%20tidal%20height%20influence%20outbreak%20of%20the%20Ostreid%20herpesvirus%20type%201%20%28OsHV-1%29%20affecting%20the%20Pacific%20oyster.%20A%20volunteer%20network%20composed%20of%2020%20oyster%20growers%20monitored%20the%20survival%20of%2028%20batches%20of%20oysters%20during%20an%20epizootic%20event%20in%20Southern%20Brittany%2C%20France.%20Oysters%20were%20spat%20from%20wild%20collection%20or%20hatchery%20production.%20The%20sampling%20sites%20were%20spread%20over%20a%20150-km%282%29%20area%20with%20a%20tidal%20height%20ranging%20from%200.98%20to%202.90%20m.%20Concomitantly%2C%20we%20followed%20survival%20of%20oyster%20spats%20in%20relation%20with%20OsHV-1%20DNA%20detection%20at%20two%20sites%20and%20conducted%20risk%20analysis.%20We%20found%20that%20tidal%20height%20was%20associated%20with%20a%20lower%20risk%20of%20mortality.%20This%20effect%20was%20higher%20for%20hatchery%20than%20for%20wild%20oysters%20probably%20reflecting%20differences%20in%20health%20status.%20Our%20study%20opens%20perspectives%20for%20mitigation%20strategies%20based%20on%20tidal%20height%20and%20emphasizes%20the%20value%20of%20volunteer%20science%20in%20marine%20epidemiological%20studies.%22%2C%22date%22%3A%22NOV-DEC%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1093%5C%2Ficesjms%5C%2Ffsz074%22%2C%22ISSN%22%3A%221054-3139%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Ficesjms%5C%2Fadvance-article%5C%2Fdoi%5C%2F10.1093%5C%2Ficesjms%5C%2Ffsz074%5C%2F5477843%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A57%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22NE8QLDHQ%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Petton%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPetton%2C%20B.%2C%20de%20Lorgeril%2C%20J.%2C%20Mitta%2C%20G.%2C%20Daigle%2C%20G.%2C%20Pernet%2C%20F.%2C%20%26amp%3B%20Alunno-Bruscia%2C%20M.%20%282019%29.%20Fine-scale%20temporal%20dynamics%20of%20herpes%20virus%20and%20vibrios%20in%20seawater%20during%20a%20polymicrobial%20infection%20in%20the%20Pacific%20oyster%20Crassostrea%20gigas.%20%3Ci%3EDiseases%20of%20Aquatic%20Organisms%3C%5C%2Fi%3E%2C%20%3Ci%3E135%3C%5C%2Fi%3E%282%29%2C%2097%26%23x2013%3B106.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Fdao03384%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3354%5C%2Fdao03384%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DNE8QLDHQ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Fine-scale%20temporal%20dynamics%20of%20herpes%20virus%20and%20vibrios%20in%20seawater%20during%20a%20polymicrobial%20infection%20in%20the%20Pacific%20oyster%20Crassostrea%20gigas%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaetan%22%2C%22lastName%22%3A%22Daigle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Alunno-Bruscia%22%7D%5D%2C%22abstractNote%22%3A%22The%20Pacific%20oyster%20Crassostrea%20gigas%20is%20currently%20being%20impacted%20by%20a%20polymicrobial%20disease%20that%20involves%20early%20viral%20infection%20by%20ostreid%20herpesvirus-1%20%28OsHV-1%29%20followed%20by%20a%20secondary%20bacterial%20infection%20leading%20to%20death.%20A%20widely%20used%20method%20of%20inducing%20infection%20consists%20of%20placing%20specific%20pathogen-free%20oysters%20%28%27recipients%27%29%20in%20cohabitation%20in%20the%20laboratory%20with%20diseased%20oysters%20that%20were%20naturally%20infected%20in%20the%20field%20%28%27donors%27%29.%20With%20this%20method%2C%20we%20evaluated%20the%20temporal%20dynamics%20of%20pathogen%20release%20in%20seawater%20and%20the%20cohabitation%20time%20necessary%20for%20disease%20transmission%20and%20expression.%20We%20showed%20that%20OsHV-1%20and%20Vibrio%20spp.%20in%20the%20seawater%20peaked%20concomitantly%20during%20the%20first%2048%20h%20and%20decreased%20thereafter.%20We%20found%20that%201.5%20h%20of%20cohabitation%20with%20donors%20was%20enough%20time%20to%20transmit%20pathogens%20to%20recipients%20and%20to%20induce%20mortality%20later%2C%20reflecting%20the%20highly%20contagious%20nature%20of%20the%20disease.%20Finally%2C%20mortality%20of%20recipients%20was%20associated%20with%20increasing%20cohabitation%20time%20with%20donors%20until%20reaching%20a%20plateau%20at%2020%25.%20This%20reflects%20the%20cumulative%20effect%20of%20exposure%20to%20pathogens.%20The%20optimal%20cohabitation%20time%20was%205-6%20d%2C%20the%20mortality%20of%20recipients%20occurring%201-2%20d%20earlier.%22%2C%22date%22%3A%222019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3354%5C%2Fdao03384%22%2C%22ISSN%22%3A%220177-5103%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.int-res.com%5C%2Fabstracts%5C%2Fdao%5C%2Fv135%5C%2Fn2%5C%2Fp97-106%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A57%3A10Z%22%7D%7D%2C%7B%22key%22%3A%228CDLSCGF%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wegner%20et%20al.%22%2C%22parsedDate%22%3A%222019-09-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWegner%2C%20K.%20M.%2C%20Piel%2C%20D.%2C%20Bruto%2C%20M.%2C%20John%2C%20U.%2C%20Mao%2C%20Z.%2C%20Alunno-Bruscia%2C%20M.%2C%20Petton%2C%20B.%2C%20%26amp%3B%20Le%20Roux%2C%20F.%20%282019%29.%20Molecular%20Targets%20for%20Coevolutionary%20Interactions%20Between%20Pacific%20Oyster%20Larvae%20and%20Their%20Sympatric%20Vibrios.%20%3Ci%3EFrontiers%20in%20Microbiology%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%2C%202067.%20https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffmicb.2019.02067%5C%2Ffull.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2019.02067%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffmicb.2019.02067%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3D8CDLSCGF%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecular%20Targets%20for%20Coevolutionary%20Interactions%20Between%20Pacific%20Oyster%20Larvae%20and%20Their%20Sympatric%20Vibrios%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20Mathias%22%2C%22lastName%22%3A%22Wegner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Piel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Bruto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uwe%22%2C%22lastName%22%3A%22John%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhijuan%22%2C%22lastName%22%3A%22Mao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Alunno-Bruscia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frdrique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%5D%2C%22abstractNote%22%3A%22Bacteria%20of%20the%20Vibrio%20genus%20are%20the%20most%20predominant%20infectious%20agents%20threatening%20marine%20wildlife%20and%20aquaculture.%20Due%20to%20the%20large%20genetic%20diversity%20of%20these%20pathogens%2C%20the%20molecular%20determinants%20of%20Vibrio%20virulence%20are%20only%20poorly%20understood.%20Furthermore%2C%20studies%20tend%20to%20ignore%20co-evolutionary%20interactions%20between%20different%20host%20populations%20and%20their%20locally%20encountered%20Vibrio%20communities.%20Here%2C%20we%20explore%20the%20molecular%20targets%20of%20such%20co-evolutionary%20interactions%20by%20analyzing%20the%20genomes%20of%20nine%20Vibrio%20strains%20from%20the%20Splendidus-clade%20showing%20opposite%20virulence%20patterns%20towards%20two%20populations%20of%20Pacific%20oysters%20introduced%20into%20European%20Wadden%20Sea.%20By%20contrasting%20Vibrio%20phylogeny%20to%20their%20host%20specific%20virulence%20patterns%2C%20we%20could%20identify%20two%20core%20genome%20genes%20%28OG1907%20and%20OG%203159%29%20that%20determine%20the%20genotype%20by%20genotype%20%28G%20x%20G%29%20interactions%20between%20oyster%20larvae%20and%20their%20sympatric%20Vibrio%20communities.%20Both%20genes%20show%20positive%20selection%20between%20locations%20targeting%20only%20few%20amino%20acid%20positions.%20Deletion%20of%20each%20gene%20led%20to%20a%20loss%20of%20the%20host%20specific%20virulence%20patterns%20while%20complementation%20with%20OG3159%20alleles%20from%20both%20locations%20could%20recreate%20the%20wild%20type%20phenotypes%20matching%20the%20origin%20of%20the%20allele.%20This%20indicates%20that%20both%20genes%20can%20act%20as%20a%20genetic%20switch%20for%20Vibrio-oyster%20coevolution%20demonstrating%20that%20local%20adaptation%20in%20distinct%20Vibrio%20lineages%20can%20rely%20on%20only%20few%20genes%20independent%20of%20larger%20pathogenicity%20islands%20or%20plasmids.%22%2C%22date%22%3A%22SEP%206%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3389%5C%2Ffmicb.2019.02067%22%2C%22ISSN%22%3A%221664-302X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00512%5C%2F62409%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A57%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22FKFVE4FW%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gourault%20et%20al.%22%2C%22parsedDate%22%3A%222019-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGourault%2C%20M.%2C%20%3Cstrong%3EPetton%2C%20S.%3C%5C%2Fstrong%3E%2C%20Thomas%2C%20Y.%2C%20Pecquerie%2C%20L.%2C%20Marques%2C%20G.%20M.%2C%20Cassou%2C%20C.%2C%20Fleury%2C%20E.%2C%20Paulet%2C%20Y.-M.%2C%20%26amp%3B%20Pouvreau%2C%20S.%20%282019%29.%20Modeling%20reproductive%20traits%20of%20an%20invasive%20bivalve%20species%20under%20contrasting%20climate%20scenarios%20from%201960%20to%202100.%20%3Ci%3EJournal%20of%20Sea%20Research%3C%5C%2Fi%3E%2C%20%3Ci%3E143%3C%5C%2Fi%3E%2C%20128%26%23x2013%3B139.%20fdi%3A010074829%26%23x202F%3B%3B%20https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00440%5C%2F55188%5C%2F.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.seares.2018.05.005%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.seares.2018.05.005%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DFKFVE4FW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Modeling%20reproductive%20traits%20of%20an%20invasive%20bivalve%20species%20under%20contrasting%20climate%20scenarios%20from%201960%20to%202100%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melaine%22%2C%22lastName%22%3A%22Gourault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoann%22%2C%22lastName%22%3A%22Thomas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Pecquerie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Goncalo%20M.%22%2C%22lastName%22%3A%22Marques%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Cassou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves-Marie%22%2C%22lastName%22%3A%22Paulet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22Pouvreau%22%7D%5D%2C%22abstractNote%22%3A%22Identifying%20the%20drivers%20that%20control%20the%20reproductive%20success%20of%20a%20population%20is%20vital%20to%20forecasting%20the%20consequences%20of%20climate%20change%20in%20terms%20of%20distribution%20shift%20and%20population%20dynamics.%20In%20the%20present%20study%2C%20we%20aimed%20to%20improve%20our%20understanding%20of%20the%20environmental%20conditions%20that%20allowed%20the%20colonization%20of%20the%20Pacific%20oyster%2C%20Crassostrea%20gigas%2C%20in%20the%20Bay%20of%20Brest%20since%20its%20introduction%20in%20the%201960s.%20We%20also%20aimed%20to%20evaluate%20the%20potential%20consequences%20of%20future%20climate%20change%20on%20its%20reproductive%20success%20and%20further%20expansion.%20Three%20reproductive%20traits%20were%20defined%20to%20study%20the%20success%20of%20the%20reproduction%3A%20the%20spawning%20occurrence%2C%20synchronicity%20among%20individuals%20and%20individual%20fecundity.%20We%20simulated%20these%20traits%20by%20applying%20an%20individual-based%20modeling%20approach%20using%20a%20Dynamic%20Energy%20Budget%20%28DEB%29%20model.%20First%2C%20the%20model%20was%20calibrated%20for%20C.%20gigas%20in%20the%20Bay%20of%20Brest%20using%20a%206-year%20monitoring%20dataset%20%282009-2014%29.%20Second%2C%20we%20reconstructed%20past%20temperature%20conditions%20since%201960%20in%20order%20to%20run%20the%20model%20backwards%20%28hindcasting%20analysis%29%20and%20identified%20the%20emergence%20of%20conditions%20that%20favored%20increasing%20reproductive%20success.%20Third%2C%20we%20explored%20the%20regional%20consequences%20of%20two%20contrasting%20IPCC%20climate%20scenarios%20%28RCP2.6%20and%20RCP8.5%29%20on%20the%20reproductive%20success%20of%20this%20species%20in%20the%20bay%20for%20the%202100%20horizon%20%28forecasting%20analysis%29.%20In%20both%20analyses%2C%20since%20phytoplankton%20concentration%20variations%20were%2C%20at%20that%20point%2C%20unknown%20in%20the%20past%20and%20unpredicted%20in%20the%20future%2C%20we%20made%20an%20initial%20assumption%20that%20our%20six%20years%20of%20observed%20phytoplankton%20concentrations%20were%20informative%20enough%20to%20represent%20%5C%22past%20and%20future%20possibilities%5C%22%20of%20phytoplankton%20dynamics%20in%20the%20Bay%20of%20Brest.%20Therefore%2C%20temperature%20is%20the%20variable%20that%20we%20modified%20under%20each%20forecasting%20and%20hindcasting%20runs.%20The%20hindcasting%20simulations%20showed%20that%20the%20spawning%20events%20increased%20after%201995%2C%20which%20agrees%20with%20the%20observations%20made%20on%20C.%20gigas%20colonization.%20The%20forecasting%20simulations%20showed%20that%20under%20the%20warmer%20scenario%20%28RCP8.5%29%2C%20reproductive%20success%20would%20be%20enhanced%20through%20two%20complementary%20mechanisms%3A%20more%20regular%20spawning%20each%20year%20and%20potentially%20precocious%20spawning%20resulting%20in%20a%20larval%20phase%20synchronized%20with%20the%20most%20favorable%20summer%20period.%20Our%20results%20evidenced%20that%20the%20spawning%20dates%20and%20synchronicity%20between%20individuals%20mainly%20relied%20on%20phytoplankton%20seasonal%20dynamics%2C%20and%20not%20on%20temperature%20as%20expected.%20Future%20research%20focused%20on%20phytoplankton%20dynamics%20under%20different%20climate%20change%20scenarios%20would%20greatly%20improve%20our%20ability%20to%20anticipate%20the%20reproductive%20success%20and%20population%20dynamics%20of%20this%20species%20and%20other%20similar%20invertebrates.%22%2C%22date%22%3A%22JAN%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.seares.2018.05.005%22%2C%22ISSN%22%3A%221385-1101%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1385110118300236%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A52%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22HBZ3SWPX%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Castrec%20et%20al.%22%2C%22parsedDate%22%3A%222019-03%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECastrec%2C%20J.%2C%20H%26%23xE9%3Bgaret%2C%20H.%2C%20Alunno-Bruscia%2C%20M.%2C%20Picard%2C%20M.%2C%20Soudant%2C%20P.%2C%20Petton%2C%20B.%2C%20Boulais%2C%20M.%2C%20Suquet%2C%20M.%2C%20Queau%2C%20I.%2C%20Ratiskol%2C%20D.%2C%20Foulon%2C%20V.%2C%20Le%20Goic%2C%20N.%2C%20%26amp%3B%20Fabioux%2C%20C.%20%282019%29.%20The%20dinoflagellate%20Alexandrium%20minutum%20affects%20development%20of%20the%20oyster%20Crassostrea%20gigas%2C%20through%20parental%20or%20direct%20exposure.%20%3Ci%3EEnvironmental%20Pollution%3C%5C%2Fi%3E%2C%20%3Ci%3E246%3C%5C%2Fi%3E%2C%20827%26%23x2013%3B836.%20http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0269749118343781.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.envpol.2018.11.084%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.envpol.2018.11.084%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DHBZ3SWPX%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20dinoflagellate%20Alexandrium%20minutum%20affects%20development%20of%20the%20oyster%20Crassostrea%20gigas%2C%20through%20parental%20or%20direct%20exposure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justine%22%2C%22lastName%22%3A%22Castrec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H%5Cu00e9l%5Cu00e8ne%22%2C%22lastName%22%3A%22H%5Cu00e9garet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Alunno-Bruscia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mailys%22%2C%22lastName%22%3A%22Picard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Soudant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Myrina%22%2C%22lastName%22%3A%22Boulais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Suquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Queau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Ratiskol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentin%22%2C%22lastName%22%3A%22Foulon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelly%22%2C%22lastName%22%3A%22Le%20Goic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Fabioux%22%7D%5D%2C%22abstractNote%22%3A%22Harmful%20algal%20blooms%20are%20a%20threat%20to%20aquatic%20organisms%20and%20coastal%20ecosystems.%20Among%20harmful%20species%2C%20the%20widespread%20distributed%20genus%20Alexandrium%20is%20of%20global%20importance.%20This%20genus%20is%20well-known%20for%20the%20synthesis%20of%20paralytic%20shellfish%20toxins%20which%20are%20toxic%20for%20humans%20through%20the%20consumption%20of%20contaminated%20shellfish.%20While%20the%20effects%20of%20Alexandrium%20species%20upon%20the%20physiology%20of%20bivalves%20are%20now%20well%20documented%2C%20consequences%20on%20reproduction%20remain%20poorly%20studied.%20In%20France%2C%20Alexandrium%20minutum%20blooms%20have%20been%20recurrent%20for%20the%20last%20decades%2C%20generally%20appearing%20during%20the%20reproduction%20season%20of%20most%20bivalves%20including%20the%20oyster%20Crassostrea%20gigas.%20These%20blooms%20could%20not%20only%20affect%20gametogenesis%20but%20also%20spawning%2C%20larval%20development%20or%20juvenile%20recruitment.%20This%20study%20assesses%20the%20effect%20of%20toxic%20A.%20minutum%20blooms%20on%20C%20gigas%20reproduction.%20Adult%20oysters%20were%20experimentally%20exposed%20to%20A.%20minutum%2C%20at%20environmentally%20realistic%20concentrations%20%2810%282%29%20to%2010%283%29%20cells%20mL%28-1%29%29%20for%20two%20months%20during%20their%20gametogenesis%20and%20a%20control%20group%2C%20not%20exposed%20to%20A.%20minutum%20was%20fed%20with%20a%20non-toxic%20dinoflagellate.%20To%20determine%20both%20consequences%20to%20next%20generation%20and%20direct%20effects%20of%20A.%20minutum%20exposure%20on%20larvae%2C%20the%20embryo-larval%20development%20of%20subsequent%20offspring%20was%20conducted%20with%20and%20without%20A.%20minutum%20exposure%20at%2010%282%29%20cells%20mL%28-1%29.%20Effects%20at%20each%20stage%20of%20the%20reproduction%20were%20investigated%20on%20ecophysiological%20parameters%2C%20cellular%20responses%2C%20and%20offspring%20development.%20Broodstock%20exposed%20to%20A.%20minutum%20produced%20spermatozoa%20with%20decreased%20motility%20and%20larvae%20of%20smaller%20size%20which%20showed%20higher%20mortalities%20during%20settlement.%20Embryo-larval%20exposure%20to%20A.%20minutum%20significantly%20reduced%20growth%20and%20settlement%20of%20larvae%20compared%20to%20non-exposed%20offspring.%20This%20detrimental%20consequence%20on%20larval%20growth%20was%20stronger%20in%20larvae%20derived%20from%20control%20parents%20compared%20to%20offspring%20from%20exposed%20parents.%20This%20study%20provides%20evidence%20that%20A.%20minutum%20blooms%2C%20whether%20they%20occur%20during%20gametogenesis%2C%20spawning%20or%20larval%20development%2C%20can%20either%20affect%20gamete%20quality%20and%5C%2For%20larval%20development%20of%20C%20gigas%2C%20thus%20potentially%20impacting%20oyster%20recruitment.%20%28C%29%202018%20Elsevier%20Ltd.%20All%20rights%20reserved.%22%2C%22date%22%3A%22MAR%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.envpol.2018.11.084%22%2C%22ISSN%22%3A%220269-7491%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00469%5C%2F58099%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A51%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22CT5CJDV4%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fuhrmann%20et%20al.%22%2C%22parsedDate%22%3A%222019-03-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFuhrmann%2C%20M.%2C%20Richard%2C%20G.%2C%20Quere%2C%20C.%2C%20Petton%2C%20B.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282019%29.%20Low%20pH%20reduced%20survival%20of%20the%20oyster%20Crassostrea%20gigas%20exposed%20to%20the%20Ostreid%20herpesvirus%201%20by%20altering%20the%20metabolic%20response%20of%20the%20host.%20%3Ci%3EAquaculture%3C%5C%2Fi%3E%2C%20%3Ci%3E503%3C%5C%2Fi%3E%2C%20167%26%23x2013%3B174.%20http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0044848618321860.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.aquaculture.2018.12.052%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.aquaculture.2018.12.052%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DCT5CJDV4%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Low%20pH%20reduced%20survival%20of%20the%20oyster%20Crassostrea%20gigas%20exposed%20to%20the%20Ostreid%20herpesvirus%201%20by%20altering%20the%20metabolic%20response%20of%20the%20host%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Fuhrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaelle%22%2C%22lastName%22%3A%22Richard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudie%22%2C%22lastName%22%3A%22Quere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22Environmental%20change%20in%20the%20marine%20realm%20has%20been%20accompanied%20by%20emerging%20diseases%20as%20new%20pathogens%20evolve%20to%20take%20advantage%20of%20hosts%20weakened%20by%20environmental%20stress.%20Here%20we%20investigated%20how%20an%20exposure%20to%20reduced%20seawater%20pH%20influenced%20the%20response%20of%20the%20oyster%20Crassostrea%20gigas%20to%20an%20infection%20by%20the%20Ostreid%20herpesvirus%20type%20I%20%28OsHV-1%29.%20Oysters%20were%20acclimated%20at%20pH%208.1%20or%20pH%207.8%20and%20then%20exposed%20to%20OsHV-1.%20Their%20survival%20was%20monitored%20and%20oyster%20tissues%20were%20sampled%20for%20biochemical%20analyses.%20The%20survival%20of%20oysters%20exposed%20to%20OsHV-1%20at%20pH%207.8%20was%20lower%20%2833.5%25%29%20than%20that%20of%20their%20counterparts%20at%20pH%208.1%20%2844.8%25%29%20whereas%20levels%20of%20OsHV-1%20DNA%20were%20similar.%20Energetic%20reserves%2C%20fatty%20acid%20composition%20and%20prostaglandin%20levels%20in%20oyster%20did%20not%20vary%20consistently%20with%20pH%2C%20infection%20or%20their%20interactions.%20However%2C%20there%20was%20a%20reduction%20in%20the%20activities%20of%20superoxide%20dismutase%20%28SOD%29%20and%20nitric%20oxide%20synthase%20%28iNOS%29%20in%20oysters%20at%20low%20pH%2C%20which%20is%20associated%20with%20the%20observed%20difference%20in%20survival.%22%2C%22date%22%3A%22MAR%2030%202019%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.aquaculture.2018.12.052%22%2C%22ISSN%22%3A%220044-8486%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00472%5C%2F58334%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22ZV9XYGXT%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A51%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22CLSNX8F4%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Delisle%20et%20al.%22%2C%22parsedDate%22%3A%222018-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDelisle%2C%20L.%2C%20Petton%2C%20B.%2C%20Burguin%2C%20J.%20F.%2C%20Morga%2C%20B.%2C%20Corporeau%2C%20C.%2C%20%26amp%3B%20Pernet%2C%20F.%20%282018%29.%20Temperature%20modulate%20disease%20susceptibility%20of%20the%20Pacific%20oyster%20Crassostrea%20gigas%20and%20virulence%20of%20the%20Ostreid%20herpesvirus%20type%201.%20%3Ci%3EFish%20%26amp%3B%20Shellfish%20Immunology%3C%5C%2Fi%3E%2C%20%3Ci%3E80%3C%5C%2Fi%3E%2C%2071%26%23x2013%3B79.%20http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS1050464818303267.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.fsi.2018.05.056%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.fsi.2018.05.056%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DCLSNX8F4%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Temperature%20modulate%20disease%20susceptibility%20of%20the%20Pacific%20oyster%20Crassostrea%20gigas%20and%20virulence%20of%20the%20Ostreid%20herpesvirus%20type%201%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lizenn%22%2C%22lastName%22%3A%22Delisle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Francois%22%2C%22lastName%22%3A%22Burguin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Morga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Corporeau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%5D%2C%22abstractNote%22%3A%22Temperature%20triggers%20marine%20diseases%20by%20changing%20host%20susceptibility%20and%20pathogen%20virulence.%20Oyster%20mortalities%20associated%20with%20the%20Ostreid%20herpesvirus%20type%201%20%28OsHV-1%29%20have%20occurred%20seasonally%20in%20Europe%20when%20the%20seawater%20temperature%20range%20reaches%2016-24%20degrees%20C.%20Here%20we%20assess%20how%20temperature%20modulates%20oyster%20susceptibility%20to%20OsHV-1%20and%20pathogen%20virulence.%20Oysters%20were%20injected%20with%20OsHV-1%20suspension%20incubated%20at%2021%20degrees%20C%2C%2026%20degrees%20C%20and%2029%20degrees%20C%20and%20were%20placed%20in%20cohabitation%20with%20healthy%20oysters%20%28recipients%29%20at%20these%20three%20temperatures%20according%20to%20a%20fractional%20factorial%20design.%20Survival%20was%20followed%20for%2014%20d%20and%20recipients%20were%20sampled%20for%20OsHV-1%20DNA%20quantification%20and%20viral%20gene%20expression.%20The%20oysters%20were%20all%20subsequently%20placed%20at%2021%20degrees%20C%20to%20evaluate%20the%20potential%20for%20virus%20reactivation%2C%20before%20being%20transferred%20to%20oyster%20farms%20to%20evaluate%20their%20long-term%20susceptibility%20to%20the%20disease.%20Survival%20of%20recipients%20at%2029%20degrees%20C%20%2886%25%29%20was%20higher%20than%20at%2021%20degrees%20C%20%2852%25%29%20and%2026%20degrees%20C%20%2843%25%29.%20High%20temperature%20%2829%20degrees%20C%29%20decreased%20the%20susceptibility%20of%20oysters%20to%20OsHV-1%20without%20altering%20virus%20infectivity%20and%20virulence.%20At%2026%20degrees%20C%2C%20the%20virulence%20of%20OsHV-1%20was%20enhanced.%20Differences%20in%20survival%20persisted%20when%20the%20recipients%20were%20all%20placed%20at%2021%20degrees%20C%2C%20suggesting%20that%20OsHV-1%20did%20not%20reactivate.%20Additional%20oyster%20mortality%20followed%20the%20field%20transfer%2C%20but%20the%20overall%20survival%20of%20oysters%20infected%20at%2029%20degrees%20C%20remained%20higher.%22%2C%22date%22%3A%22SEP%202018%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.fsi.2018.05.056%22%2C%22ISSN%22%3A%221050-4648%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00442%5C%2F55337%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22SC48RKDK%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A27%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22NMCSM3Z5%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bruto%20et%20al.%22%2C%22parsedDate%22%3A%222018-12%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBruto%2C%20M.%2C%20Labreuche%2C%20Y.%2C%20James%2C%20A.%2C%20Piel%2C%20D.%2C%20Chenivesse%2C%20S.%2C%20Petton%2C%20B.%2C%20Polz%2C%20M.%20F.%2C%20%26amp%3B%20Le%20Roux%2C%20F.%20%282018%29.%20Ancestral%20gene%20acquisition%20as%20the%20key%20to%20virulence%20potential%20in%20environmental%20Vibrio%20populations.%20%3Ci%3EThe%20ISME%20Journal%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%2812%29%2C%202954%26%23x2013%3B2966.%20https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41396-018-0245-3.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41396-018-0245-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41396-018-0245-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DNMCSM3Z5%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ancestral%20gene%20acquisition%20as%20the%20key%20to%20virulence%20potential%20in%20environmental%20Vibrio%20populations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Bruto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Labreuche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adele%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Piel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Chenivesse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20F.%22%2C%22lastName%22%3A%22Polz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%5D%2C%22abstractNote%22%3A%22Diseases%20of%20marine%20animals%20caused%20by%20bacteria%20of%20the%20genus%20Vibrio%20are%20on%20the%20rise%20worldwide.%20Understanding%20the%20eco-evolutionary%20dynamics%20of%20these%20infectious%20agents%20is%20important%20for%20predicting%20and%20managing%20these%20diseases.%20Yet%2C%20compared%20to%20Vibrio%20infecting%20humans%2C%20knowledge%20of%20their%20role%20as%20animal%20pathogens%20is%20scarce.%20Here%20we%20ask%20how%20widespread%20is%20virulence%20among%20ecologically%20differentiated%20Vibrio%20populations%2C%20and%20what%20is%20the%20nature%20and%20frequency%20of%20virulence%20genes%20within%20these%20populations%3F%20We%20use%20a%20combination%20of%20population%20genomics%20and%20molecular%20genetics%20to%20assay%20hundreds%20of%20Vibrio%20strains%20for%20their%20virulence%20in%20the%20oyster%20Crassostrea%20gigas%2C%20a%20unique%20animal%20model%20that%20allows%20high-throughput%20infection%20assays.%20We%20show%20that%20within%20the%20diverse%20Splendidus%20Glade%2C%20virulence%20represents%20an%20ancestral%20trait%20but%20has%20been%20lost%20from%20several%20populations.%20Two%20loci%20are%20necessary%20for%20virulence%2C%20the%20first%20being%20widely%20distributed%20across%20the%20Splendidus%20Glade%20and%20consisting%20of%20an%20exported%20conserved%20protein%20%28R5.7%29.%20The%20second%20is%20a%20MARTX%20toxin%20cluster%2C%20which%20only%20occurs%20within%20V.%20splendidus%20and%20is%20for%20the%20first%20time%20associated%20with%20virulence%20in%20marine%20invertebrates.%20Varying%20frequencies%20of%20both%20loci%20among%20populations%20indicate%20different%20selective%20pressures%20and%20alternative%20ecological%20roles%2C%20based%20on%20which%20we%20suggest%20strategies%20for%20epidemiological%20surveys.%22%2C%22date%22%3A%22DEC%202018%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41396-018-0245-3%22%2C%22ISSN%22%3A%221751-7362%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00452%5C%2F56370%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22SC48RKDK%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A21%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22B3PTBCVB%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pernet%20et%20al.%22%2C%22parsedDate%22%3A%222018-07-18%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPernet%2C%20F.%2C%20Fuhrmann%2C%20M.%2C%20Petton%2C%20B.%2C%20Mazurie%2C%20J.%2C%20Bouget%2C%20J.-F.%2C%20Fleury%2C%20E.%2C%20Daigle%2C%20G.%2C%20%26amp%3B%20Gernez%2C%20P.%20%282018%29.%20Determination%20of%20risk%20factors%20for%20herpesvirus%20outbreak%20in%20oysters%20using%20a%20broad-scale%20spatial%20epidemiology%20framework.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E8%3C%5C%2Fi%3E%2C%2010869.%20https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00450%5C%2F56130%5C%2F.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-018-29238-4%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-018-29238-4%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DB3PTBCVB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Determination%20of%20risk%20factors%20for%20herpesvirus%20outbreak%20in%20oysters%20using%20a%20broad-scale%20spatial%20epidemiology%20framework%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Pernet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marine%22%2C%22lastName%22%3A%22Fuhrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%22%2C%22lastName%22%3A%22Mazurie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Francois%22%2C%22lastName%22%3A%22Bouget%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Fleury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gaetan%22%2C%22lastName%22%3A%22Daigle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Gernez%22%7D%5D%2C%22abstractNote%22%3A%22Marine%20diseases%20have%20major%20impacts%20on%20ecosystems%20and%20economic%20consequences%20for%20aquaculture%20and%20fisheries.%20Understanding%20origin%2C%20spread%20and%20risk%20factors%20of%20disease%20is%20crucial%20for%20management%2C%20but%20data%20in%20the%20ocean%20are%20limited%20compared%20to%20the%20terrestrial%20environment.%20Here%20we%20investigated%20how%20the%20marine%20environment%20drives%20the%20spread%20of%20viral%20disease%20outbreak%20affecting%20The%20Pacific%20oyster%20worldwide%20by%20using%20a%20spatial%20epidemiology%20framework.%20We%20collected%20environmental%20and%20oyster%20health%20data%20at%2046%20sites%20spread%20over%20an%20area%20of%20300%20km%282%29%20along%20an%20inshore-offshore%20gradient%20during%20an%20epizootic%20event%20and%20conducted%20risk%20analysis.%20We%20found%20that%20disease%20broke%20out%20in%20the%20intertidal%20farming%20area%20and%20spread%20seaward.%20Mortalities%20and%20virus%20detection%20were%20observed%20in%20oysters%20placed%202%20km%20from%20the%20farming%20areas%2C%20but%20oysters%20of%20almost%20all%20sites%20were%20subclinically%20infected.%20Increasing%20food%20quantity%20and%20quality%2C%20growth%20rate%20and%20energy%20reserves%20of%20oyster%20were%20associated%20with%20a%20lower%20risk%20of%20mortality%20offshore%20whereas%20increasing%20turbidity%2C%20a%20proxy%20of%20the%20concentration%20of%20suspended%20particulate%20matter%2C%20and%20terrestrial%20inputs%2C%20inferred%20from%20fatty%20acid%20composition%20of%20oysters%2C%20were%20associated%20with%20a%20higher%20risk%20of%20mortality.%20Offshore%20farming%20and%20maintenance%20of%20good%20ecological%20status%20of%20coastal%20waters%20are%20options%20to%20limit%20disease%20risk%20in%20oysters.%22%2C%22date%22%3A%22JUL%2018%202018%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-018-29238-4%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-018-29238-4.pdf%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22SC48RKDK%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A19%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22ULGCK97F%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Lorgeril%20et%20al.%22%2C%22parsedDate%22%3A%222018-10-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3Ede%20Lorgeril%2C%20J.%2C%20Lucasson%2C%20A.%2C%20Petton%2C%20B.%2C%20Toulza%2C%20E.%2C%20Montagnani%2C%20C.%2C%20Clerissi%2C%20C.%2C%20Vidal-Dupiol%2C%20J.%2C%20Chaparro%2C%20C.%2C%20Galinier%2C%20R.%2C%20Escoubas%2C%20J.-M.%2C%20Haffner%2C%20P.%2C%20Degremont%2C%20L.%2C%20Charriere%2C%20G.%20M.%2C%20Lafont%2C%20M.%2C%20Delort%2C%20A.%2C%20Vergnes%2C%20A.%2C%20Chiarello%2C%20M.%2C%20Faury%2C%20N.%2C%20Rubio%2C%20T.%2C%20%26%23x2026%3B%20Mitta%2C%20G.%20%282018%29.%20Immune-suppression%20by%20OsHV-1%20viral%20infection%20causes%20fatal%20bacteraemia%20in%20Pacific%20oysters.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E9%3C%5C%2Fi%3E%281%29%2C%204215.%20https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-018-06659-3.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-018-06659-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-018-06659-3%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DULGCK97F%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Immune-suppression%20by%20OsHV-1%20viral%20infection%20causes%20fatal%20bacteraemia%20in%20Pacific%20oysters%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22de%20Lorgeril%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aude%22%2C%22lastName%22%3A%22Lucasson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eve%22%2C%22lastName%22%3A%22Toulza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Montagnani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Clerissi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremie%22%2C%22lastName%22%3A%22Vidal-Dupiol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristian%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Galinier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Michel%22%2C%22lastName%22%3A%22Escoubas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Haffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Degremont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%20M.%22%2C%22lastName%22%3A%22Charriere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Lafont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Abigail%22%2C%22lastName%22%3A%22Delort%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%22%2C%22lastName%22%3A%22Vergnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marlene%22%2C%22lastName%22%3A%22Chiarello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Faury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tristan%22%2C%22lastName%22%3A%22Rubio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%20A.%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adeline%22%2C%22lastName%22%3A%22Perignon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Regler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Morga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marianne%22%2C%22lastName%22%3A%22Alunno-Bruscia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Boudry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frederique%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Delphine%22%2C%22lastName%22%3A%22Destoumieux-Garzon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Gueguen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guillaume%22%2C%22lastName%22%3A%22Mitta%22%7D%5D%2C%22abstractNote%22%3A%22Infectious%20diseases%20are%20mostly%20explored%20using%20reductionist%20approaches%20despite%20repeated%20evidence%20showing%20them%20to%20be%20strongly%20influenced%20by%20numerous%20interacting%20host%20and%20environmental%20factors.%20Many%20diseases%20with%20a%20complex%20aetiology%20therefore%20remain%20misunderstood.%20By%20developing%20a%20holistic%20approach%20to%20tackle%20the%20complexity%20of%20interactions%2C%20we%20decipher%20the%20complex%20intra-host%20interactions%20underlying%20Pacific%20oyster%20mortality%20syndrome%20affecting%20juveniles%20of%20Crassostrea%20gigas%2C%20the%20main%20oyster%20species%20exploited%20worldwide.%20Using%20experimental%20infections%20reproducing%20the%20natural%20route%20of%20infection%20and%20combining%20thorough%20molecular%20analyses%20of%20oyster%20families%20with%20contrasted%20susceptibilities%2C%20we%20demonstrate%20that%20the%20disease%20is%20caused%20by%20multiple%20infection%20with%20an%20initial%20and%20necessary%20step%20of%20infection%20of%20oyster%20haemocytes%20by%20the%20Ostreid%20herpesvirus%20OsHV-1%20mu%20Var.%20Viral%20replication%20leads%20to%20the%20host%20entering%20an%20immune-compromised%20state%2C%20evolving%20towards%20subsequent%20bacteraemia%20by%20opportunistic%20bacteria.%20We%20propose%20the%20application%20of%20our%20integrative%20approach%20to%20decipher%20other%20multifactorial%20diseases%20that%20affect%20non-model%20species%20worldwide.%22%2C%22date%22%3A%22OCT%2011%202018%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-018-06659-3%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00461%5C%2F57234%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22SC48RKDK%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A19%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22CT3NPDPC%22%2C%22library%22%3A%7B%22id%22%3A355235%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tallec%20et%20al.%22%2C%22parsedDate%22%3A%222018-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETallec%2C%20K.%2C%20Huvet%2C%20A.%2C%20Di%20Poi%2C%20C.%2C%20Gonzalez-Fernandez%2C%20C.%2C%20Lambert%2C%20C.%2C%20Petton%2C%20B.%2C%20Le%20Goic%2C%20N.%2C%20Berchel%2C%20M.%2C%20Soudant%2C%20P.%2C%20%26amp%3B%20Paul-Pont%2C%20I.%20%282018%29.%20Nanoplastics%20impaired%20oyster%20free%20living%20stages%2C%20gametes%20and%20embryos.%20%3Ci%3EEnvironmental%20Pollution%3C%5C%2Fi%3E%2C%20%3Ci%3E242%3C%5C%2Fi%3E%2C%201226%26%23x2013%3B1235.%20http%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0269749118329725.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.envpol.2018.08.020%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.envpol.2018.08.020%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww-iuem.univ-brest.fr%5C%2Flemar%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D355235%26amp%3Bitem_key%3DCT3NPDPC%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nanoplastics%20impaired%20oyster%20free%20living%20stages%2C%20gametes%20and%20embryos%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kevin%22%2C%22lastName%22%3A%22Tallec%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Huvet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Di%20Poi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Gonzalez-Fernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christophe%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Petton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelly%22%2C%22lastName%22%3A%22Le%20Goic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathieu%22%2C%22lastName%22%3A%22Berchel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Soudant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ika%22%2C%22lastName%22%3A%22Paul-Pont%22%7D%5D%2C%22abstractNote%22%3A%22In%20the%20marine%20environment%2C%20most%20bivalve%20species%20base%20their%20reproduction%20on%20external%20fertilization.%20Hence%2C%20gametes%20and%20young%20stages%20face%20many%20threats%2C%20including%20exposure%20to%20plastic%20wastes%20which%20represent%20more%20than%2080%25%20of%20the%20debris%20in%20the%20oceans.%20Recently%2C%20evidence%20has%20been%20produced%20on%20the%20presence%20of%20nanoplastics%20in%20oceans%2C%20thus%20motivating%20new%20studies%20of%20their%20impacts%20on%20marine%20life.%20Because%20no%20information%20is%20available%20about%20their%20environmental%20concentrations%2C%20we%20performed%20dose-response%20exposure%20experiments%20with%20polystyrene%20particles%20to%20assess%20the%20extent%20of%20micro%5C%2Fnanoplastic%20toxicity.%20Effects%20of%20polystyrene%20with%20different%20sizes%20and%20functionalizations%20%28plain%202-mu%20m%2C%20500-nm%20and%2050-nm%3B%20COOH-50%20nm%20and%20NH2-50%20nm%29%20were%20assessed%20on%20three%20key%20reproductive%20steps%20%28fertilization%2C%20embryogenesis%20and%20metamorphosis%29%20of%20Pacific%20oysters%20%28Crassostrea%20gigas%29.%20Nanoplastics%20induced%20a%20significant%20decrease%20in%20fertilization%20success%20and%20in%20embryo-larval%20development%20with%20numerous%20malformations%20up%20to%20total%20developmental%20arrest.%20The%20NH2-50%20beads%20had%20the%20strongest%20toxicity%20to%20both%20gametes%20%28EC50%20%3D%204.9%20mu%20g%5C%2FmL%29%20and%20embryos%20%28EC50%20%3D%200.15%20mu%20g%5C%2FmL%29%2C%20showing%20functionalization-dependent%20toxicity.%20No%20effects%20of%20plain%20microplastics%20were%20recorded.%20These%20results%20highlight%20that%20exposures%20to%20nanoplastics%20may%20have%20deleterious%20effects%20on%20planktonic%20stages%20of%20oysters%2C%20presumably%20interacting%20with%20biological%20membranes%20and%20causing%20cyto%5C%2Fgenotoxicity%20with%20potentially%20drastic%20consequences%20for%20their%20reproductive%20success.%20%28C%29%202018%20Elsevier%20Ltd.%20All%20rights%20reserved.%22%2C%22date%22%3A%22NOV%202018%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.envpol.2018.08.020%22%2C%22ISSN%22%3A%220269-7491%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchimer.ifremer.fr%5C%2Fdoc%5C%2F00453%5C%2F56419%5C%2F%22%2C%22collections%22%3A%5B%22348HK8H3%22%2C%22SC48RKDK%22%5D%2C%22dateModified%22%3A%222020-10-29T13%3A19%3A04Z%22%7D%7D%5D%7D
Petton, S., Pernet, F., Le Roy, V., Huber, M., Martin, S., Mace, E., Bozec, Y., Loisel, S., Rimmelin-Maury, P., Grossteffan, E., Repecaud, M., Quemener, L., Retho, M., Manac’h, S., Papin, M., Pineau, P., Lacoue-Labarthe, T., Deborde, J., Costes, L., … Gazeau, F. (2024). French coastal network for carbonate system monitoring: the CocoriCO2 dataset. EARTH SYSTEM SCIENCE DATA, 16(4), 1667–1688. https://doi.org/10.5194/essd-16-1667-2024 Cite
Metzl, N., Fin, J., Lo Monaco, C., Mignon, C., Alliouane, S., Antoine, D., Bourdin, G., Boutin, J., Bozec, Y., Conan, P., Coppola, L., Diaz, F., Douville, E., de Madron, X. D., Gattuso, J.-P., Gazeau, F., Golbol, M., Lansard, B., Lefevre, D., … Wimart-Rousseau, C. (2024). A synthesis of ocean total alkalinity and dissolved inorganic carbon measurements from 1993 to 2022: the SNAPO-CO2-v1 dataset. EARTH SYSTEM SCIENCE DATA, 16(1), 89–120. https://doi.org/10.5194/essd-16-89-2024 Cite
Dantan, L., Toulza, E., Petton, B., Montagnani, C., Degremont, L., Morga, B., Fleury, Y., Mitta, G., Gueguen, Y., Vidal-Dupiol, J., & Cosseau, C. (2024). Microbial education for marine invertebrate disease prevention in aquaculture. REVIEWS IN AQUACULTURE. https://doi.org/10.1111/raq.12893 Cite
Gawra, J., Valdivieso, A., Roux, F., Laporte, M., de Lorgeril, J., Gueguen, Y., Saccas, M., Escoubas, J.-M., Montagnani, C., Destoumieux-Garzon, D., Lagarde, F., Leroy, M. A., Haffner, P., Petton, B., Cosseau, C., Morga, B., Degremont, L., Mitta, G., Grunau, C., & Vidal-Dupiol, J. (2023). Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome. SCIENCE ADVANCES, 9(36), eadh8990. https://doi.org/10.1126/sciadv.adh8990 Cite
Oyanedel, D., Lagorce, A., Bruto, M., Haffner, P., Morot, A., Labreuche, Y., Dorant, Y., Divonne, S. de L. F., Delavat, F., Inguimbert, N., Montagnani, C., Morga, B., Toulza, E., Chaparro, C., Escoubas, J.-M., Gueguen, Y., Vidal-Dupiol, J., de Lorgeril, J., Petton, B., … Destoumieux-Garzon, D. (2023). Cooperation and cheating orchestrate Vibrio assemblages and polymicrobial synergy in oysters infected with OsHV-1 virus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(40), e2305195120. https://doi.org/10.1073/pnas.2305195120 Cite
Dupoue, A., Mello, D. F., Trevisan, R., Dubreuil, C., Queau, I., Petton, S., Huvet, A., Guevel, B., Com, E., Pernet, F., Salin, K., Fleury, E., & Corporeau, C. (2023). Intertidal limits shape covariation between metabolic plasticity, oxidative stress and telomere dynamics in Pacific oyster (Crassostrea gigas). MARINE ENVIRONMENTAL RESEARCH, 191, 106149. https://doi.org/10.1016/j.marenvres.2023.106149 Cite
Piel, D., Bruto, M., Labreuche, Y., Blanquart, F., Goudenege, D., Barcia-Cruz, R., Chenivesse, S., Le Panse, S., James, A., Dubert, J., Petton, B., Lieberman, E., Wegner, K. M., Hussain, F. A., Kauffman, K. M., Polz, M. F., Bikard, D., Gandon, S., Rocha, E. P. C., & Le Roux, F. (2022). Phage-host coevolution in natural populations. Nature Microbiology, 7(7), 1075-+. https://doi.org/10.1038/s41564-022-01157-1 Cite
Guillou, N., Chapalain, G., & Petton, S. (2023). Predicting sea surface salinity in a tidal estuary with machine learning. Oceanologia, 65(2), 318–332. https://doi.org/10.1016/j.oceano.2022.07.007 Cite
Clerissi, C., Luo, X., Lucasson, A., Mortaza, S., De Lorgeril, J., Toulza, E., Petton, B., Escoubas, J.-M., Dégremont, L., Gueguen, Y., Destoumieux-Garzόn, D., Jacq, A., & Mitta, G. (2023). A core of functional complementary bacteria infects oysters in Pacific Oyster Mortality Syndrome. Animal Microbiome, 5(1), 26. https://doi.org/10.1186/s42523-023-00246-8 Cite
Lemonnier, C., Chalopin, M., Huvet, A., Le Roux, F., Labreuche, Y., Petton, B., Maignien, L., Paul-Pont, I., & Reveillaud, J. (2022). Time-series incubations in a coastal environment illuminates the importance of early colonizers and the complexity of bacterial biofilm dynamics on marine plastics. Environmental Pollution, 312, 119994. https://doi.org/10.1016/j.envpol.2022.119994 Cite
Fallet, M., Montagnani, C., Petton, B., Dantan, L., de Lorgeril, J., Comarmond, S., Chaparro, C., Toulza, E., Boitard, S., Escoubas, J.-M., Vergnes, A., Le Grand, J., Bulla, I., Gueguen, Y., Vidal-Dupiol, J., Grunau, C., Mitta, G., & Cosseau, C. (2022). Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection. Microbiome, 10(1), 85. https://doi.org/10.1186/s40168-022-01280-5 Cite
Petton, B., Alunno-Bruscia, M., Mitta, G., & Pernet, F. (2023). Increased growth metabolism promotes viral infection in a susceptible oyster population. Aquaculture Environment Interactions, 15, 19–33. https://doi.org/10.3354/aei00450 Cite
Bruyere, O., Soulard, B., Lemonnier, H., Laugier, T., Hubert, M., Petton, S., Desclaux, T., Van Wynsberge, S., Le Tesson, E., Lefevre, J., Dumas, F., Kayara, J.-F., Bourassin, E., Lalau, N., Antypas, F., & Le Gendre, R. (2022). Hydrodynamic and hydrological processes within a variety of coral reeflagoons: field observations during six cyclonic seasons in New Caledonia. Earth System Science Data, 14(12), 5439–5462. https://doi.org/10.5194/essd-14-5439-2022 Cite
Nicolas, N. D. S., Asokan, A., Rosa, R. D., Voisin, S. N., Travers, M.-A., Rocha, G., Dantan, L., Dorant, Y., Mitta, G., Petton, B., Charriere, G. M., Escoubas, J.-M., Boulo, V., Pouzadoux, J., Meudal, H., Loth, K., Aucagne, V., Delmas, A. F., Bulet, P., … Destoumieux-Garzon, D. (2022). Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota. Marine Drugs, 20(12), 745. https://doi.org/10.3390/md20120745 Cite
Soree, M., Delavat, F., Lambert, C., Lozach, S., Papin, M., Petton, B., Passerini, D., Degremont, L., & Heath, D. H. (2022). Life history of oysters influences Vibrio parahaemolyticus accumulation in Pacific oysters (Crassostrea gigas). Environmental Microbiology. https://doi.org/10.1111/1462-2920.15996 Cite
Lalau, N., Van Wynsberge, S., Soulard, B., Petton, S., & Le Gendre, R. (2022). A quick and cost-effective method for modelling water renewal in shallow coral reef lagoons. Coral Reefs. https://doi.org/10.1007/s00338-022-02319-7 Cite
Corporeau, C., Petton, S., Vilaca, R., Delisle, L., Quere, C., Le Roy, V., Dubreuil, C., Lacas-Gervais, S., Guitton, Y., Artigaud, S., Bernay, B., Pichereau, V., Huvet, A., Petton, B., Pernet, F., Fleury, E., Madec, S., Brigaudeau, C., Brenner, C., & Mazure, N. M. (2022). Harsh intertidal environment enhances metabolism and immunity in oyster (Crassostrea gigas) spat. Marine Environmental Research, 180, 105709. https://doi.org/10.1016/j.marenvres.2022.105709 Cite
Delmotte, J., Pelletier, C., Morga, B., Galinier, R., Petton, B., Lamy, J.-B., Kaltz, O., Avarre, J.-C., Jacquot, M., Montagnani, C., & Escoubas, J.-M. (2022). Genetic diversity and connectivity of the Ostreid herpesvirus 1 populations in France: A first attempt to phylogeographic inference for a marine mollusc disease. Virus Evolution, 8(1). https://doi.org/10.1093/ve/veac039 Cite
Poppeschi, C., Charria, G., Goberville, E., Rimmelin-Maury, P., Barrier, N., Petton, S., Unterberger, M., Grossteffan, E., Repecaud, M., Quemener, L., Theetten, S., Le Roux, J.-F., & Tréguer, P. (2021). Unraveling Salinity Extreme Events in Coastal Environments: A Winter Focus on the Bay of Brest. Frontiers in Marine Science, 8, 705403. https://doi.org/10.3389/fmars.2021.705403 Cite
Dugeny, E., de Lorgeril, J., Petton, B., Toulza, E., Gueguen, Y., & Pernet, F. (2022). Seaweeds influence oyster microbiota and disease susceptibility. Journal of Animal Ecology. https://doi.org/10.1111/1365-2656.13662 Cite
Offret, C., Gauthier, O., Despreaux, G., Bidault, A., Corporeau, C., Miner, P., Petton, B., Pernet, F., Fabioux, C., Paillard, C., & Le Blay, G. (2022). Microbiota of the Digestive Glands and Extrapallial Fluids of Clams Evolve Differently Over Time Depending on the Intertidal Position. Microbial Ecology. https://doi.org/10.1007/s00248-022-01959-0 Cite
Petton, B., Destoumieux-Garzon, D., Pernet, F., Toulza, E., de Lorgeril, J., Degremont, L., & Mitta, G. (2021). The Pacific Oyster Mortality Syndrome, a Polymicrobial and Multifactorial Disease: State of Knowledge and Future Directions. Frontiers in Immunology, 12, 630343. https://doi.org/10.3389/fimmu.2021.630343 Cite
Pernet, F., Lugue, K., & Petton, B. (2021). Competition for food reduces disease susceptibility in a marine invertebrate. Ecosphere, 12(4), e03435. https://doi.org/10.1002/ecs2.3435 Cite
Offret, C., Paulino, S., Gauthier, O., Chateau, K., Bidault, A., Corporeau, C., Miner, P., Petton, B., Pernet, F., Fabioux, C., Paillard, C., & Le Blay, G. (2020). The marine intertidal zone shapes oyster and clam digestive bacterial microbiota. Fems Microbiology Ecology, 96(8), fiaa078. https://doi.org/10.1093/femsec/fiaa078 Cite
Clerissi, C., de Lorgeril, J., Petton, B., Lucasson, A., Escoubas, J.-M., Gueguen, Y., Degremont, L., Mitta, G., & Toulza, E. (2020). Microbiota Composition and Evenness Predict Survival Rate of Oysters Confronted to Pacific Oyster Mortality Syndrome. Frontiers in Microbiology, 11, 311. https://archimer.ifremer.fr/doc/00621/73332/. https://doi.org/10.3389/fmicb.2020.00311 Cite
Fleury, E., Barbier, P., Petton, B., Normand, J., Thomas, Y., Pouvreau, S., Daigle, G., & Pernet, F. (2020). Latitudinal drivers of oyster mortality: deciphering host, pathogen and environmental risk factors. Scientific Reports, 10(1), 7264. https://doi.org/10.1038/s41598-020-64086-1 Cite
Petton, S., Pouvreau, S., & Dumas, F. (2020). Intensive use of Lagrangian trajectories to quantify coastal area dispersion. Ocean Dynamics. https://doi.org/10.1007/s10236-019-01343-6 Cite
de Lorgeril, J., Petton, B., Lucasson, A., Perez, V., Stenger, P.-L., Degremont, L., Montagnani, C., Escoubas, J.-M., Haffner, P., Allienne, J.-F., Leroy, M., Lagarde, F., Vidal-Dupiol, J., Gueguen, Y., & Mitta, G. (2020). Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific oyster mortality syndrome. Bmc Genomics, 21(1), 63. https://doi.org/10.1186/s12864-020-6471-x Cite
Delmotte, J., Chaparro, C., Galinier, R., de Lorgeril, J., Petton, B., Stenger, P.-L., Vidal-Dupiol, J., Destoumieux-Garzon, D., Gueguen, Y., Montagnani, C., Escoubas, J.-M., & Mitta, G. (2020). Contribution of Viral Genomic Diversity to Oyster Susceptibility in the Pacific Oyster Mortality Syndrome. Frontiers in Microbiology, 11, 1579. https://archimer.ifremer.fr/doc/00643/75533/. https://doi.org/10.3389/fmicb.2020.01579 Cite
Lafont, M., Vergnes, A., Vidal-Dupiol, J., de Lorgeril, J., Gueguen, Y., Haffner, P., Petton, B., Chaparro, C., Barrachina, C., Destoumieux-Garzon, D., Mitta, G., Gourbal, B., & Montagnani, C. (2020). A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas. Mbio, 11(2), e02777-19. https://doi.org/10.1128/mBio.02777-19 Cite
Le Franc, L., Bernay, B., Petton, B., Since, M., Favrel, P., & Riviere, G. (2020). A functional m(6)A-RNA methylation pathway in the oysterCrassostrea gigasassumes epitranscriptomic regulation of lophotrochozoan development. Febs Journal, Early virw. https://doi.org/10.1111/febs.15500 Cite
Trotter, A. J., Vignier, J., Wilson, T. K., Douglas, M., Adams, S. L., King, N., Cunningham, M. P., Carter, C. G., Boudry, P., Petton, B., Degremont, L., Smith, G. G., & Pernet, F. (2021). Case study of vertical transmission of ostreid herpesvirus-1 in Pacific oysters and biosecurity management based on epidemiological data from French, New Zealand and Australian hatchery-propagated seed. Aquaculture Research. https://doi.org/10.1111/are.15219 Cite
Tallec, K., Paul-Pont, I., Petton, B., Alunno-Bruscia, M., Bourdon, C., Bernardini, I., Boulais, M., Lambert, C., Quere, C., Bideau, A., Le Goic, N., Cassone, A.-L., Le Grand, F., Fabioux, C., Soudant, P., & Huvet, A. (2021). Amino-nanopolystyrene exposures of oyster (Crassostrea gigas) embryos induced no apparent intergenerational effects. Nanotoxicology, 15(4), 477–493. https://doi.org/10.1080/17435390.2021.1879963 Cite
Lupo, C., Dutta, B. L., Petton, S., Ezanna, P., Tourbiez, D., Travers, M.-A., Pernet, F., & Bacher, C. (2020). Spatial epidemiological modelling of infection by Vibrio aestuarianus shows that connectivity and temperature control oyster mortality. Aquaculture Environment Interactions, 12, 511–527. https://doi.org/10.3354/aei00379 Cite
Delisle, L., Pauletto, M., Vidal-Dupiol, J., Petton, B., Bargelloni, L., Montagnani, C., Pernet, F., Corporeau, C., & Fleury, E. (2020). High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival. Journal of Experimental Biology, 223(20), jeb226233. https://doi.org/10.1242/jeb.226233 Cite
Piel, D., Bruto, M., James, A., Labreuche, Y., Lambert, C., Janicot, A., Chenivesse, S., Petton, B., Wegner, K. M., Stoudmann, C., Blokesch, M., & Le Roux, F. (2019). Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells. Environmental Microbiology. https://doi.org/10.1111/1462-2920.14776 Cite
Gangnery, A., Normand, J., Duval, C., Cugier, P., Grangere, K., Petton, B., Petton, S., Orvain, F., & Pernet, F. (2019). Connectivities with shellfish farms and channel rivers are associated with mortality risk in oysters. Aquaculture Environment Interactions, 11, 493–506. https://archimer.ifremer.fr/doc/00588/69983/. https://doi.org/10.3354/aei00327 Cite
Rubio, T., Oyanedel, D., Labreuche, Y., Toulza, E., Luo, X., Bruto, M., Chaparro, C., Torres, M., de Lorgeril, J., Haffner, P., Vidal-Dupiol, J., Lagorce, A., Petton, B., Mitta, G., Jacq, A., Le Roux, F., Charriere, G. M., & Destoumieux-Garzon, D. (2019). Species-specific mechanisms of cytotoxicity toward immune cells determine the successful outcome of Vibrio infections. Proceedings of the National Academy of Sciences of the United States of America, 116(28), 14238–14247. https://doi.org/10.1073/pnas.1905747116 Cite
Pernet, F., Tamayo, D., Fuhrmann, M., & Petton, B. (2019). Deciphering the effect of food availability, growth and host condition on disease susceptibility in a marine invertebrate. Journal of Experimental Biology, 222(17), UNSP jeb210534. https://doi.org/10.1242/jeb.210534 Cite
Pernet, F., Gachelin, S., Stanisiere, J.-Y., Petton, B., Fleury, E., & Mazurie, J. (2019). Farmer monitoring reveals the effect of tidal height on mortality risk of oysters during a herpesvirus outbreak. ICES Journal of Marine Science, 76(6), 1816–1824. https://archimer.ifremer.fr/doc/00491/60271/. https://doi.org/10.1093/icesjms/fsz074 Cite
Petton, B., de Lorgeril, J., Mitta, G., Daigle, G., Pernet, F., & Alunno-Bruscia, M. (2019). Fine-scale temporal dynamics of herpes virus and vibrios in seawater during a polymicrobial infection in the Pacific oyster Crassostrea gigas. Diseases of Aquatic Organisms, 135(2), 97–106. https://doi.org/10.3354/dao03384 Cite
Wegner, K. M., Piel, D., Bruto, M., John, U., Mao, Z., Alunno-Bruscia, M., Petton, B., & Le Roux, F. (2019). Molecular Targets for Coevolutionary Interactions Between Pacific Oyster Larvae and Their Sympatric Vibrios. Frontiers in Microbiology, 10, 2067. https://www.frontiersin.org/articles/10.3389/fmicb.2019.02067/full. https://doi.org/10.3389/fmicb.2019.02067 Cite
Gourault, M., Petton, S., Thomas, Y., Pecquerie, L., Marques, G. M., Cassou, C., Fleury, E., Paulet, Y.-M., & Pouvreau, S. (2019). Modeling reproductive traits of an invasive bivalve species under contrasting climate scenarios from 1960 to 2100. Journal of Sea Research, 143, 128–139. fdi:010074829 ; https://archimer.ifremer.fr/doc/00440/55188/. https://doi.org/10.1016/j.seares.2018.05.005 Cite
Castrec, J., Hégaret, H., Alunno-Bruscia, M., Picard, M., Soudant, P., Petton, B., Boulais, M., Suquet, M., Queau, I., Ratiskol, D., Foulon, V., Le Goic, N., & Fabioux, C. (2019). The dinoflagellate Alexandrium minutum affects development of the oyster Crassostrea gigas, through parental or direct exposure. Environmental Pollution, 246, 827–836. http://www.sciencedirect.com/science/article/pii/S0269749118343781. https://doi.org/10.1016/j.envpol.2018.11.084 Cite
Fuhrmann, M., Richard, G., Quere, C., Petton, B., & Pernet, F. (2019). Low pH reduced survival of the oyster Crassostrea gigas exposed to the Ostreid herpesvirus 1 by altering the metabolic response of the host. Aquaculture, 503, 167–174. http://www.sciencedirect.com/science/article/pii/S0044848618321860. https://doi.org/10.1016/j.aquaculture.2018.12.052 Cite
Delisle, L., Petton, B., Burguin, J. F., Morga, B., Corporeau, C., & Pernet, F. (2018). Temperature modulate disease susceptibility of the Pacific oyster Crassostrea gigas and virulence of the Ostreid herpesvirus type 1. Fish & Shellfish Immunology, 80, 71–79. http://www.sciencedirect.com/science/article/pii/S1050464818303267. https://doi.org/10.1016/j.fsi.2018.05.056 Cite
Bruto, M., Labreuche, Y., James, A., Piel, D., Chenivesse, S., Petton, B., Polz, M. F., & Le Roux, F. (2018). Ancestral gene acquisition as the key to virulence potential in environmental Vibrio populations. The ISME Journal, 12(12), 2954–2966. https://www.nature.com/articles/s41396-018-0245-3. https://doi.org/10.1038/s41396-018-0245-3 Cite
Pernet, F., Fuhrmann, M., Petton, B., Mazurie, J., Bouget, J.-F., Fleury, E., Daigle, G., & Gernez, P. (2018). Determination of risk factors for herpesvirus outbreak in oysters using a broad-scale spatial epidemiology framework. Scientific Reports, 8, 10869. https://archimer.ifremer.fr/doc/00450/56130/. https://doi.org/10.1038/s41598-018-29238-4 Cite
de Lorgeril, J., Lucasson, A., Petton, B., Toulza, E., Montagnani, C., Clerissi, C., Vidal-Dupiol, J., Chaparro, C., Galinier, R., Escoubas, J.-M., Haffner, P., Degremont, L., Charriere, G. M., Lafont, M., Delort, A., Vergnes, A., Chiarello, M., Faury, N., Rubio, T., … Mitta, G. (2018). Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters. Nature Communications, 9(1), 4215. https://www.nature.com/articles/s41467-018-06659-3. https://doi.org/10.1038/s41467-018-06659-3 Cite
Tallec, K., Huvet, A., Di Poi, C., Gonzalez-Fernandez, C., Lambert, C., Petton, B., Le Goic, N., Berchel, M., Soudant, P., & Paul-Pont, I. (2018). Nanoplastics impaired oyster free living stages, gametes and embryos. Environmental Pollution, 242, 1226–1235. http://www.sciencedirect.com/science/article/pii/S0269749118329725. https://doi.org/10.1016/j.envpol.2018.08.020 Cite
