Sylvain PETEK

Chimie des substances naturelles marines, base de données, plongeur scientifique

Chargé(e) de recherche
IRD Ouest

Affectation

Laboratoire LEMAR

Panorama

Contact

Sylvain.Petek@ird.fr

02 98 49 86 51 - Bureau A148

Liens

Ma page Researchgate

N° ORCID: 0000-0001-7920-0467

Mes photos sur IRD Multimedia

Mes publications sur IRD Horizon

Substances naturelles marines: D’une manière générale, je m’intéresse aux substances naturelles d’origine marine et aux organismes dont elles proviennent pour une meilleure compréhension du vivant, mais également dans l’objectif de les valoriser que ce soit en santé humaine, en aquaculture, ou dans d’autres secteurs, en réponse à des problématiques locales et/ou des pays du Sud et contribuer par ailleurs, à l’émergence de nouveaux axes de développement économique.

Les différentes recherches que j’entreprends au sein de mon équipe, s’intègrent dans un projet global mené depuis plusieurs années avec ma collègue Cécile Debitus, ayant pour thème « Biodiversité et substances marines du Pacifique sud ». Il est question d’une part de parfaire les connaissances de la faune et de la flore des récifs coralliens du Pacifique sud et d’autre part de rechercher de nouveaux principes actifs naturels contre différentes pathologies (humaines ou aquacoles), ou à valoriser économiquement.

Cantharella: un outils dédié à l’étude des substances naturelles: Avec Adrien Cheype (ingénieur du pôle informatique scientifique, IRD Nouméa), et par la suite avec la société Code Lutin, nous avons développé le système d’information (SI) Cantharella. Cet outil de travail collaboratif accessible via internet de manière sécurisée, est dédié aux travaux sur les substances naturelles quelle qu’en soit l’origine. Il permet de capitaliser, pérenniser et partager de manière contrôlée les données entre collaborateurs d’un projet, mais également d’effectuer une restitution auprès des territoires et pays d’où proviennent les organismes étudiés dans le cadre de la démarche d’APA (Accès et Partage des Avantages). De nouveaux développements ont été effectués en 2022 (société Code Lutin, financement IRD dept OCEANS) offrant de nouvelles fonctionnalités aux utilisateurs (fonctions d’imports de données, SIG, amélioration de la gestion de droits…). Le logiciel est diffusé gratuitement sous licence libre (HAL-01887126).

Sites d’étude:

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Campagnes océanographiques :

Wallis & Futuna	2018	Alis	Wallis 2018 : S. Petek*, E. Folcher, M. Ekins, M. Oliverio, M. Dumas, J. Butscher
Polynésie fr. – Tuamotu	2018	Alis	Tuam’2018 : C. Debitus*, M. Dumas, S. Petek, T. Le Bec, V. Bouvot, M. Maslin, J. Butscher
Polynésie fr. – Tahiti	2013	Alis	Tahiti iti : C. Debitus*, S. Petek, M. Ekins, L. Hertrich, J. Butscher, P. Levy
Polynésie fr. – Australes	2013	Alis	Tuhaa Pae 2013 : C. Debitus*, E. Folcher, S. Petek, J. Butscher, B. Bourgeois, A. Berberian, A. Fedosov
Polynésie fr. – Société	2012	Golden Shadow	Global Reef Expedition : A. Bruckner*, S. Andrefouet, S. Petek et al.
Polynésie fr. – Marquises	2011	Braveheart	Pakaihi i te Moana: C. Payri*, J.-L. Menou, S. Petek et al.
Polynésie fr. – Tuamotu	2011	Alis	Tuam’2011 : C. Debitus*, E. Folcher, S. Petek, J. Butscher, B. Bourgeois, A. Renaud, D. Fleurisson, F. Lerouvreur
Polynésie fr. – Gambiers	2010	Claymore II	Coralspot : S. Plasnes*, C. Debitus, S. Petek et al.
Polynésie fr. – Marquises	2009	Alis	BSMPF1 : C. Debitus*, E. Folcher, S. Petek, J. Butscher, J. Orempuller, N. Mahiota
Fidji	2007	Alis	BSM Fidji : C. Payri*, J.-L. Menou, S. Petek, G. Lasnes, J. Butscher

Alis - Marquises

04/11/2022 – Au revoir à l’ALIS

« Comme pour beaucoup d’entre nous, l’Alis et son équipage tiennent une place particulière dans notre cœur, tant de rencontres, de tranches de vie partagées et d’explorations au fin fond du Pacifique. En ce qui me concerne, c’est à son bord que j’ai effectué ma première campagne océanographique en 2007 à Fidji, avec Claude, Jean-Louis, John et Greg… toute une aventure !

Des anecdotes il y en aurait tant à raconter… Je retiendrai de ce navire, sa convivialité, sa cuisine toujours au top pour soutenir le moral des troupes, et la faculté qu’il a eu toutes ces années de nous téléporter vers d’autres civilisations, d’autres paysages terrestres et sous-marins en parallèle de nos recherches sur les invertébrés marins… avec de nombreux coups de cœur que ce soit pour les Marquises, Rapa ou encore Wallis…

Un seul mot pour conclure, Merci !… » Sylvain Petek

Extrait du reportage IRD le Mag’, intitulé LEMAR : révéler les richesses des mers et des océans:

.avia-video.av-av_video-6d9884965833cabfb73513f077743931{ background-image:url(https://www-iuem.univ-brest.fr/lemar/wp-content/uploads/2018/09/Wallis-2018-2.jpg); }

Pour en savoir plus sur mon parcours et mes activités : mon portait dans la lettre de l’IUEM N°427 (02/2020)

Publications dans des revues à comité de lecture :

Caudal F., Roullier C., Rodrigues S., Dufour A., Artigaud S., Le Blay G., Bazire A., Petek S. (2024) Anti-Biofilm Extracts and Molecules from the Marine Environment. Marine Drugs, 2024, 22, 313. https://doi.org/10.3390/md22070313

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Boufridi, A., Lachkar, D., Erpenbeck, D., Beniddir, M. A., Evanno, L., Petek, S., Debitus, C., & Poupon, E. (2017). Ilimaquinone and 5-epi-Ilimaquinone: Beyond a Simple Diastereomeric Ratio, Biosynthetic Considerations from NMR-Based Analysis. Australian Journal of Chemistry, 70(6), 743–750. https://doi.org/10.1071/CH16455 Cite

Zubia, M., Thomas, O. P., Soulet, S., Demoy-Schneider, M., Saulnier, D., Connan, S., Murphy, E. C., Tintillier, F., Stiger-Pouvreau, V., & Petek, S. (2020). Potential of tropical macroalgae from French Polynesia for biotechnological applications. Journal of Applied Phycology. https://doi.org/10.1007/s10811-019-01920-8 Cite

El-Demerdash, A., Moriou, C., Toullec, J., Besson, M., Soulet, S., Schmitt, N., Petek, S., Lecchini, D., Debitus, C., & Al-Mourabit, A. (2018). Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis. Marine Drugs, 16(5), 146. fdi:010072564. https://doi.org/10.3390/md16050146 Cite

Tintillier, F., Moriou, C., Petek, S., Fauchon, M., Hellio, C., Saulnier, D., Ekins, M., Hooper, J. N. A., Al-Mourabit, A., & Debitus, C. (2020). Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp. Marine Drugs, 18(5), 272. fdi:010079097. https://doi.org/10.3390/md18050272 Cite

Moriou, C., Lacroix, D., Petek, S., El-Demerdash, A., Trepos, R., Leu, T. M., Florean, C., Diederich, M., Hellio, C., Debitus, C., & Al-Mourabit, A. (2021). Bioactive Bromotyrosine Derivatives from the Pacific Marine Sponge Suberea clavata (Pulitzer-Finali, 1982). Marine Drugs, 19(3), 143. https://doi.org/10.3390/md19030143 Cite

El-Demerdash, A., Petek, S., Debitus, C., & Al-Mourabit, A. (2020). Crambescidin acid from the French Polynesian Monanchora n. sp. Marine Sponge. Chemistry of Natural Compounds, 56(6), 1180–1182. https://doi.org/10.1007/s10600-020-03262-1 Cite

Evanno, L., Lachkar, D., Lamali, A., Boufridi, A., Seon-Meniel, B., Tintillier, F., Saulnier, D., Denis, S., Genta-Jouve, G., Jullian, J.-C., Leblanc, K., Beniddir, M. A., Petek, S., Debitus, C., & Poupon, E. (2018). A Ring-Distortion Strategy from Marine Natural Product Ilimaquinone Leads to Quorum Sensing Modulators. European Journal of Organic Chemistry, 20–21, 2486–2497. fdi:010073101. https://doi.org/10.1002/ejoc.201800047 Cite

El-Demerdash, A., Moriou, C., Martin, M.-T., Petek, S., Debitus, C., & Al-Mourabit, A. (2018). Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp. Natural Product Research, 32(13), 1512–1517. fdi:010073062. https://doi.org/10.1080/14786419.2017.1385011 Cite

El-Demerdash, A., Petek, S., Debitus, C., & Al-Mourabit, A. (2018). Fatty Acids Pattern from the French Polynesian Monanchora n. sp. Marine Sponge. Chemistry of Natural Compounds, 54(6), 1143–1145. fdi:010074401. https://doi.org/10.1007/s10600-018-2575-9 Cite

Bonneau, N., Chen, G., Lachkar, D., Boufridi, A., Gallard, J.-F., Retailleau, P., Petek, S., Debitus, C., Evanno, L., Beniddir, M. A., & Poupon, E. (2017). An Unprecedented Blue Chromophore Found in Nature using a “Chemistry First” and Molecular Networking Approach: Discovery of Dactylocyanines A-H. Chemistry-a European Journal, 23(58), 14454–14461. fdi:010071281. https://doi.org/10.1002/chem.201702336 Cite

Boufridi, A., Petek, S., Evanno, L., Beniddir, M. A., Debitus, C., Buisson, D., & Poupon, E. (2016). Biotransformations versus chemical modifications: new cytotoxic analogs of marine sesquiterpene ilimaquinone. Tetrahedron Letters, 57(44), 4922–4925. fdi:010068406. https://doi.org/10.1016/j.tetlet.2016.09.075 Cite

El-Demerdash A., Moriou C., Martin M.-T., Rodrigues-Stien, A., Petek S., Demoy-Schneider M., Hall K., Hooper J., Debitus C., Al-Mourabit A. (2016). Cytotoxic Guanidine Alkaloids from the French Polynesian Sponge Monanchora n. sp., J. Nat. Prod., 79, 1929-1937.

Mai T., Tintillier F., Lucasson A., Moriou C., Bonno E., Petek S., Magré K., Al-Mourabit A., Saulnier D., Debitus C. (2015). Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863, Lett. Appl. Microbiol., 61, 311-317. (Editor choice)

Laville R., Nguyen T.B., Moriou C., Petek S., Debitus C. and Al-Mourabit A. (2015). Marine natural occurring 2,5-diketopiperazines : isolation, synthesis and optical properties. Heterocycles, 90, 1351-1366.

Hall K. A., Sutcliffe P. R., Hooper J. N. A., Alencar A., Vacelet J., Pisera A., Petek S., Folcher E., Butscher J., Orempuller J., Maihota N., Debitus C. (2013). Affinities of sponges (Porifera) of the Marquesas and Society Islands, French Polynesia. Pacific Science, 67, 493-512.

Festa C., De Marino S., D’Auria M. V, Orazio Taglialatela-Scafati O., Deharo E., Petek S., Zampella A. (2013). New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands. Tetrahedron, 69, 3706-3713

Festa C., De Marino S., D’auria M. V., Deharo E., Gonzalez G., Deyssard C., Petek S., Bifulco G., Zampella A. (2012). Gracilioethers E-J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris. Tetrahedron, 68, 10157-10163.

Festa C., Lauro G., De Marino S., D’auria M. V., Monti M. C., Casapullo A., D’amore C., Renga B., Mencarelli A., Petek S., Bifulco G., Fiorucci S., Zampella A. (2012). Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ. Journal of Medicinal Chemistry, 55, 8303-8317.

De Marino S., Ummarino R., D’Auria M. V., Chini M. G., Bifulco G., D’amore C., Renga B., Mencarelli A., Petek S., Fiorucci S., Zampella A. (2012). 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity. Steroids, 77, 484-495.

Sorres J., Martin M. T., Petek S., Levaique H., Cresteil T., Ramos S., Thoison O., Debitus C., Al-Mourabit A. (2012). Pipestelides A-C: Cyclodepsipeptides from the Pacific Marine Sponge Pipestela candelabra. Journal of Natural Products, 75, 759-763.

Erpenbeck D., Hooper J., Bonnard I., Sutcliffe P., Chandra M., Perio P., Wolff C., Banaigs B., Wörheide G., Debitus C., Petek S. (2012). Evolution, radiation and chemotaxonomy of Lamellodysidea, a demosponge genus with anti-plasmodial metabolites. Marine Biology, 159, 1119-1127.

Mani L., Petek S., Valentin A., Chevalley S., Folcher E., Aalbersberg W., Debitus C. (2011). The in vivo anti-plasmodial activity of haliclonacyclamine A, an alkaloid from the marine sponge, Haliclona sp. Nat. Prod.Res., 25, 1923-1930.

Longeon A., Copp B. R., Quevrain E., Roué M., Kientz B., Cresteil T., Petek Sylvain, Debitus Cécile, Bourguet-Kondracki M. L. (2011). Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Mar. Drugs, 9, 879-888.

De Marino S., Sepe V., D’Auria M. V., Bifulco G., Renga B., Petek Sylvain, Fiorucci S., Zampella A. (2011). Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. Org. Biomol. Chem., 9, 4856-4862.

Festa, C.; De Marino, S.; D’Auria, M. V.; Bifulco, G.; Renga, B.; Fiorucci, S.; Petek, S.; Zampella, A. (2011). Solomonsterols A and B from Theonella swinhoei. The First Example of C-24 and C-23 Sulfated Sterols from a Marine Source Endowed with a PXR Agonistic Activity. J. Med. Chem., 54, 401-405.

Longeon, A., Copp, B. R., Roué, M., Dubois, J., Valentin, A., Petek, S., Debitus, C., ., Bourguet-Kondracki M. L. (2010). New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg. Med. Chem., 18, 6006-6011.

Tilvi Supriya, Moriou Celine, Martin Marie-Therese, Gallard Jean-Francois, Sorres Jonathan, Patel Kirti, Petek Sylvain, Debitus Cecile, Ermolenko Ludmila, Al-Mourabit Ali. (2010). Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha. J. Nat. Prod., 73 (4), 720-3.

De Marino S., Festa C., D’auria M. V., Bourguet-Kondracki M. L., Petek S., Debitus C., Andres R. M., Terencio M. C., Paya M., Zampella A. (2009). Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties. Tetrahedron, 65 (15), 2905-2909.

Zampella Angela, Sepe Valentina, Bellotta Filomena, Luciano Paolo, D’auria Maria Valeria, Cresteil Thierry, Debitus Cecile, Petek Sylvain, Poupat Christiane, Ahond Alain. (2009). Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp. Org. Biomol. Chem., 7 (19), 4037-44.

Appenzeller Jérôme, Mihci Ghezala, Martin Marie-Therese, Gallard Jean-François, Menou Jean-Louis, Boury-Esnault Nicole, Hooper John, Petek Sylvain, Chevalley Severine, Valentin Alexis, Zaparucha Anne, Al-Mourabit Ali, Debitus Cécile. (2008). Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana. J. Nat. Prod., 71 (8), 1451-1454.

Zampella Angela, Sepe Valentina, Luciano Paolo, Bellotta Filomena, Monti Maria Chiara, D’auria Maria Valeria, Jepsen Trine, Petek Sylvain, Adeline Marie-Therese, Laprevote Olivier, Aubertin Anne-Marie, Debitus Cécile, Poupat Christiane, Ahond Alain. (2008). Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp. J. Org. Chem., 73 (14), 5319-5327.

Grison Claude, Petek Sylvain, Coutrot Philippe. (2005). Investigation into the regioselective C-deuteriation of [alpha]-keto esters. Tetrahedron, 61 (30), 7193-7200.

Grison Claude, Petek Sylvain, Coutrot Philippe. (2005). Preparation of magnesium enolates of alpha-keto esters and synthetic applications. Synlett, (2), 331-333.

Grison Claude, Petek Sylvain, Finance Chantal, Coutrot Philippe. (2005). Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase. Carbohydrate Research, 340 (4), 529-537.

Xu Xingjue, Wang Jian, Grison Claude, Petek Sylvian, Coutrot Philippe, Birck Matthew R., Woodard Ronald W., Gatti Domenico L. (2003). Structure-based design of novel inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Drug Des Discov, 18 (2-3), 91-9.