Sylvain Petek, IRD

Sylvain PETEK

Chemistry of marine natural products, database, scientific diver

Research scientist
IRD Ouest





+33 (0)2 98 49 86 51


Ma page Researchgate

N° ORCID: 0000-0001-7920-0467

Mes photos sur IRD Multimedia

Mes publications sur IRD Horizon

Marine natural products :Generally speaking, I am interested in marine natural substances and the organisms from which they originate for a better understanding of living things, but also with the aim of valorising them whether in human health, aquaculture or other sectors, in response to local problems and/or those of the countries of the South, Sponges of Polynesiaand also to contribute to the emergence of new fields of economic development.

The various research projects that I undertake within my team are part of a global project that I have been working on for several years with my colleague Cécile Debitus, on the theme of “Biodiversity and marine substances in the South Pacific”. On the one hand, the aim is to improve our knowledge of the fauna and flora of the coral reefs of the South Pacific, and on the other hand, to search for new natural active ingredients against different pathologies (human or aquaculture), or to develop them economically.

Cantharella: a tool dedicated to the study of natural products: With Adrien Cheype (engineer from the scientific computing pole, IRD Noumea), we have developed the Cantharella information system (IS). This collaborative work tool, accessible via the Internet in a secure manner, is dedicated to work on natural products whatever their origin. It allows us to capitalize, perpetuate Cantharellaand share data in a controlled manner between project collaborators, but also to make a restitution of scientific informations to the territories and countries from which the organisms  studied within the framework of the ABS (Access and Benefit Sharing) approach originate. The software is distributed free of charge under a free license (HAL-01887126).

Survey sites :

El-Demerdash A., Moriou C., Martin M.-T., Rodrigues-Stien, A., Petek S., Demoy-Schneider M.,  Hall K., Hooper  J., Debitus C., Al-Mourabit A. (2016). Cytotoxic Guanidine Alkaloids from the French Polynesian Sponge Monanchora n. sp., J. Nat. Prod., 79, 1929-1937.

Mai T., Tintillier F., Lucasson A., Moriou C., Bonno E., Petek S., Magré K., Al-Mourabit A., Saulnier D., Debitus C. (2015). Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863, Lett. Appl. Microbiol., 61, 311-317. (Editor choice)

Laville R., Nguyen T.B., Moriou C., Petek S.,  Debitus C. and Al-Mourabit A. (2015). Marine natural occurring 2,5-diketopiperazines : isolation, synthesis and optical properties. Heterocycles, 90, 1351-1366.

Hall K. A., Sutcliffe P. R., Hooper J. N. A., Alencar A., Vacelet J., Pisera A., Petek S., Folcher E., Butscher J., Orempuller J., Maihota N., Debitus C. (2013). Affinities of sponges (Porifera) of the Marquesas and Society Islands, French Polynesia. Pacific Science, 67, 493-512.

Festa C., De Marino S., D’Auria M. V, Orazio Taglialatela-Scafati O., Deharo E., Petek S., Zampella A. (2013). New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands. Tetrahedron, 69, 3706-3713

Festa C., De Marino S., D’auria M. V., Deharo E., Gonzalez G., Deyssard C., Petek S., Bifulco G., Zampella A. (2012). Gracilioethers E-J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris. Tetrahedron, 68, 10157-10163.

Festa C., Lauro G., De Marino S., D’auria M. V., Monti M. C., Casapullo A., D’amore C., Renga B., Mencarelli A., Petek S., Bifulco G., Fiorucci S., Zampella A. (2012). Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ. Journal of Medicinal Chemistry, 55, 8303-8317.

De Marino S., Ummarino R., D’Auria M. V., Chini M. G., Bifulco G., D’amore C., Renga B., Mencarelli A., Petek S., Fiorucci S., Zampella A. (2012). 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity. Steroids, 77, 484-495.

Sorres J., Martin M. T., Petek S., Levaique H., Cresteil T., Ramos S., Thoison O., Debitus C., Al-Mourabit A. (2012). Pipestelides A-C: Cyclodepsipeptides from the Pacific Marine Sponge Pipestela candelabra. Journal of Natural Products, 75, 759-763.

Erpenbeck D., Hooper J., Bonnard I., Sutcliffe P., Chandra M., Perio P., Wolff C., Banaigs B., Wörheide G., Debitus C., Petek S. (2012). Evolution, radiation and chemotaxonomy of Lamellodysidea, a demosponge genus with anti-plasmodial metabolites. Marine Biology, 159, 1119-1127.

Mani L., Petek S., Valentin A., Chevalley S., Folcher E., Aalbersberg W., Debitus C. (2011). The in vivo anti-plasmodial activity of haliclonacyclamine A, an alkaloid from the marine sponge, Haliclona sp. Nat. Prod.Res., 25, 1923-1930.

Longeon A., Copp B. R., Quevrain E., Roué M., Kientz B., Cresteil T., Petek Sylvain, Debitus Cécile, Bourguet-Kondracki M. L. (2011). Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Mar. Drugs, 9, 879-888.

De Marino S., Sepe V., D’Auria M. V., Bifulco G., Renga B., Petek Sylvain, Fiorucci S., Zampella A. (2011). Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. Org. Biomol. Chem., 9, 4856-4862.

Festa, C.; De Marino, S.; D’Auria, M. V.; Bifulco, G.; Renga, B.; Fiorucci, S.; Petek, S.; Zampella, A. (2011). Solomonsterols  A and B from Theonella swinhoei. The First Example of C-24 and C-23 Sulfated Sterols from a Marine Source Endowed with a PXR Agonistic Activity. J.  Med. Chem., 54, 401-405.

Longeon, A., Copp, B. R., Roué, M., Dubois, J., Valentin, A., Petek, S., Debitus, C., ., Bourguet-Kondracki M. L. (2010). New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg. Med. Chem., 18, 6006-6011.

Tilvi Supriya, Moriou Celine, Martin Marie-Therese, Gallard Jean-Francois, Sorres Jonathan, Patel Kirti, Petek Sylvain, Debitus Cecile, Ermolenko Ludmila, Al-Mourabit Ali. (2010). Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha. J. Nat. Prod, 73 (4), 720-3.

De Marino S., Festa C., D’auria M. V., Bourguet-Kondracki M. L., Petek S., Debitus C., Andres R. M., Terencio M. C., Paya M., Zampella A. (2009). Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties. Tetrahedron, 65 (15), 2905-2909.

Zampella Angela, Sepe Valentina, Bellotta Filomena, Luciano Paolo, D’auria Maria Valeria, Cresteil Thierry, Debitus Cecile, Petek Sylvain, Poupat Christiane, Ahond Alain. (2009). Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp. Org. Biomol. Chem., 7 (19), 4037-44.

Appenzeller Jérôme, Mihci Ghezala, Martin Marie-Therese, Gallard Jean-François, Menou Jean-Louis, Boury-Esnault Nicole, Hooper John, Petek Sylvain, Chevalley Severine, Valentin Alexis, Zaparucha Anne, Al-Mourabit Ali, Debitus Cécile. (2008). Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana. J. Nat. Prod., 71 (8), 1451-1454.

Zampella Angela, Sepe Valentina, Luciano Paolo, Bellotta Filomena, Monti Maria Chiara, D’auria Maria Valeria, Jepsen Trine, Petek Sylvain, Adeline Marie-Therese, Laprevote Olivier, Aubertin Anne-Marie, Debitus Cécile, Poupat Christiane, Ahond Alain. (2008). Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp. J. Org. Chem., 73 (14), 5319-5327.

Grison Claude, Petek Sylvain, Coutrot Philippe. (2005). Investigation into the regioselective C-deuteriation of [alpha]-keto esters. Tetrahedron, 61 (30), 7193-7200.

Grison Claude, Petek Sylvain, Coutrot Philippe. (2005). Preparation of magnesium enolates of alpha-keto esters and synthetic applications. Synlett, (2), 331-333.

Grison Claude, Petek Sylvain, Finance Chantal, Coutrot Philippe. (2005). Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase. Carbohydrate Research, 340 (4), 529-537.

Xu Xingjue, Wang Jian, Grison Claude, Petek Sylvian, Coutrot Philippe, Birck Matthew R., Woodard Ronald W., Gatti Domenico L. (2003). Structure-based design of novel inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Drug Des Discov, 18 (2-3), 91-9.