Sylvain PETEK
Chemistry of marine natural products, database, scientific diver
Research scientist
IRD Ouest
Copyright : Laboratoire LEMAR- 2018
Assignment
LEMAR Lab
Panorama
Contact
+33 (0)2 98 49 86 51
Links
Marine natural products :Generally speaking, I am interested in marine natural substances and the organisms from which they originate for a better understanding of living things, but also with the aim of valorising them whether in human health, aquaculture or other sectors, in response to local problems and/or those of the countries of the South, and also to contribute to the emergence of new fields of economic development.
The various research projects that I undertake within my team are part of a global project that I have been working on for several years with my colleague Cécile Debitus, on the theme of “Biodiversity and marine substances in the South Pacific”. On the one hand, the aim is to improve our knowledge of the fauna and flora of the coral reefs of the South Pacific, and on the other hand, to search for new natural active ingredients against different pathologies (human or aquaculture), or to develop them economically.
Cantharella: a tool dedicated to the study of natural products: With Adrien Cheype (engineer from the scientific computing pole, IRD Noumea), we have developed the Cantharella information system (IS). This collaborative work tool, accessible via the Internet in a secure manner, is dedicated to work on natural products whatever their origin. It allows us to capitalize, perpetuate and share data in a controlled manner between project collaborators, but also to make a restitution of scientific informations to the territories and countries from which the organisms studied within the framework of the ABS (Access and Benefit Sharing) approach originate. The software is distributed free of charge under a free license (HAL-01887126).
Survey sites :
Articles published in peer-reviewed journals:
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El-Demerdash A., Moriou C., Martin M.-T., Rodrigues-Stien, A., Petek S., Demoy-Schneider M., Hall K., Hooper J., Debitus C., Al-Mourabit A. (2016). Cytotoxic Guanidine Alkaloids from the French Polynesian Sponge Monanchora n. sp., J. Nat. Prod., 79, 1929-1937.
Sinane, M., Grunberger, C., Gentile, L., Moriou, C., Chaker, V., Coutrot, P., Guenneguez, A., Poullaouec, M.-A., Connan, S., Stiger-Pouvreau, V., Zubia, M., Fleury, Y., Cerantola, S., Kervarec, N., Al-Mourabit, A., Petek, S., & Voisset, C. (2024). Potential of Marine Sponge Metabolites against Prions: Bromotyrosine Derivatives, a Family of Interest. MARINE DRUGS, 22(10), 456. https://doi.org/10.3390/md22100456 Cite
Caudal, F., Roullier, C., Rodrigues, S., Dufour, A., Artigaud, S., Le Blay, G., Bazire, A., & Petek, S. (2024). Anti-Biofilm Extracts and Molecules from the Marine Environment. MARINE DRUGS, 22(7), 313. https://doi.org/10.3390/md22070313 Cite
Galitz, A., Ekins, M., Reddy, M. M., Folcher, E., Dumas, M., Butscher, J., Thomas, O. P., Voigt, O., Woerheide, G., Petek, S., & Erpenbeck, D. (2024). Molecular genetic biodiversity assessment of the Wallis Island sponge fauna in the Tropical Pacific. JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM, 104, e56. https://doi.org/10.1017/S0025315424000432 Cite
Jourdain de Muizon, C., Moriou, C., Levasseur, M., Touboul, D., Iorga, B. I., Nedev, H., Van Elslande, E., Retailleau, P., Petek, S., Folcher, E., Bianchi, A., Thomas, M., Viallon, S., Peyroche, S., Nahle, S., Rousseau, M., & Al-Mourabit, A. (2024). Chemical Investigation of the Calcareous Marine Sponge Pericharax heteroraphis, Clathridine-A Related Derivatives Isolation, Synthesis and Osteogenic Activity. MARINE DRUGS, 22(5), 196. https://doi.org/10.3390/md22050196 Cite
Paulino, S., Petek, S., Le Strat, Y., Bourgougnon, N., & Le Blay, G. (2024). Cultivable epiphytic bacteria of the Chlorophyta Ulva sp.: diversity, antibacterial, and biofilm-modulating activities. JOURNAL OF APPLIED MICROBIOLOGY, 135(5), lxae099. https://doi.org/10.1093/jambio/lxae099 Cite
Garcia-Corona, J. L., Fabioux, C., Vanmaldergem, J., Petek, S., Derrien, A., Terre-Terrillon, A., Bressolier, L., Breton, F., & Hegaret, H. (2024). The amnesic shellfish poisoning toxin, domoic acid: The tattoo of the king scallop Pecten maximus. HARMFUL ALGAE, 133, 102607. https://doi.org/10.1016/j.hal.2024.102607 Cite
Gager, L., Connan, S., Cerantola, S., Petek, S., Couteau, C., Coiffard, L., & Stiger-Pouvreau, V. (2024). An Eco-Friendly Extraction and Purification Approach for Obtaining Active Ingredients for Cosmetics from Two Marine Brown Seaweeds. MARINE DRUGS, 22(3), 112. https://doi.org/10.3390/md22030112 Cite
Galitz, A., Ekins, M., Folcher, E., Büttner, G., Hall, K., Hooper, J. N. A., Reddy, M. M., Schätzle, S., Thomas, O. P., Wörheide, G., Petek, S., Debitus, C., & Erpenbeck, D. (2023). Poriferans rift apart: molecular demosponge biodiversity in Central and French Polynesia and comparison with adjacent marine provinces of the Central Indo-Pacific. Biodiversity and Conservation, 32(7), 2469–2494. https://doi.org/10.1007/s10531-023-02613-y Cite
Ekins, M., Erpenbeck, D., Debitus, C., Petek, S., Mai, T., Woerheide, G., & Hooper, J. N. A. (2023). Revision of the genus Fascaplysinopsis, the type species Fascaplysinopsis reticulata (Hentschel, 1912) (Porifera, Dictyoceratida, Thorectidae) and descriptions of two new genera and seven new species. ZOOTAXA, 5346(3), 201–241. https://doi.org/10.11646/zootaxa.5346.3.1 Cite
Caudal, F., Rodrigues, S., Dufour, A., Artigaud, S., Le Blay, G., Petek, S., & Bazire, A. (2023). Extracts from Wallis Sponges Inhibit Vibrio harveyi Biofilm Formation. MICROORGANISMS, 11(7), 1762. https://doi.org/10.3390/microorganisms11071762 Cite
de Muizon, C. J., Moriou, C., Petek, S., Ekins, M., Rousseau, M., & Al Mourabit, A. (2022). Isolation, Synthesis and Absolute Configuration of the Pericharaxins A and B, Epimeric Hydroxy-Polyene Glycerol Ethers from the Calcarean Sponge Pericharax heteroraphis. Marine Drugs, 20(10), 635. https://doi.org/10.3390/md20100635 Cite
Moriou, C., Lacroix, D., Petek, S., El-Demerdash, A., Trepos, R., Leu, T. M., Florean, C., Diederich, M., Hellio, C., Debitus, C., & Al-Mourabit, A. (2021). Bioactive Bromotyrosine Derivatives from the Pacific Marine Sponge Suberea clavata (Pulitzer-Finali, 1982). Marine Drugs, 19(3), 143. https://doi.org/10.3390/md19030143 Cite
El-Demerdash, A., Petek, S., Debitus, C., & Al-Mourabit, A. (2020). Crambescidin acid from the French Polynesian Monanchora n. sp. Marine Sponge. Chemistry of Natural Compounds, 56(6), 1180–1182. https://doi.org/10.1007/s10600-020-03262-1 Cite
Zubia, M., Thomas, O. P., Soulet, S., Demoy-Schneider, M., Saulnier, D., Connan, S., Murphy, E. C., Tintillier, F., Stiger-Pouvreau, V., & Petek, S. (2020). Potential of tropical macroalgae from French Polynesia for biotechnological applications. Journal of Applied Phycology. fdi:010077106. https://doi.org/10.1007/s10811-019-01920-8 Cite
Zubia, M., Thomas, O. P., Soulet, S., Demoy-Schneider, M., Saulnier, D., Connan, S., Murphy, E. C., Tintillier, F., Stiger-Pouvreau, V., & Petek, S. (2020). Potential of tropical macroalgae from French Polynesia for biotechnological applications. Journal of Applied Phycology. https://doi.org/10.1007/s10811-019-01920-8 Cite
Tintillier, F., Moriou, C., Petek, S., Fauchon, M., Hellio, C., Saulnier, D., Ekins, M., Hooper, J. N. A., Al-Mourabit, A., & Debitus, C. (2020). Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp. Marine Drugs, 18(5), 272. fdi:010079097. https://doi.org/10.3390/md18050272 Cite
Mai, T., Toullec, J., Van Wynsberge, S., Besson, M., Soulet, S., Petek, S., Aliotti, E., Ekins, M., Hall, K., Erpenbeck, D., Lecchini, D., Beniddir, M. A., Saulnier, D., & Debitus, C. (2019). Potential of fascaplysin and palauolide from Fascaplysinopsis cf reticulata to reduce the risk of bacterial infection in fish farming. Fisheries and Aquatic Sciences, 22(1). fdi:010077691. https://doi.org/10.1186/s41240-019-0145-0 Cite
El-Demerdash, A., Moriou, C., Martin, M.-T., Petek, S., Debitus, C., & Al-Mourabit, A. (2018). Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp. Natural Product Research, 32(13), 1512–1517. fdi:010073062. https://doi.org/10.1080/14786419.2017.1385011 Cite
El-Demerdash, A., Petek, S., Debitus, C., & Al-Mourabit, A. (2018). Fatty Acids Pattern from the French Polynesian Monanchora n. sp. Marine Sponge. Chemistry of Natural Compounds, 54(6), 1143–1145. fdi:010074401. https://doi.org/10.1007/s10600-018-2575-9 Cite
Evanno, L., Lachkar, D., Lamali, A., Boufridi, A., Seon-Meniel, B., Tintillier, F., Saulnier, D., Denis, S., Genta-Jouve, G., Jullian, J.-C., Leblanc, K., Beniddir, M. A., Petek, S., Debitus, C., & Poupon, E. (2018). A Ring-Distortion Strategy from Marine Natural Product Ilimaquinone Leads to Quorum Sensing Modulators. European Journal of Organic Chemistry, 20–21, 2486–2497. fdi:010073101. https://doi.org/10.1002/ejoc.201800047 Cite
El-Demerdash, A., Moriou, C., Toullec, J., Besson, M., Soulet, S., Schmitt, N., Petek, S., Lecchini, D., Debitus, C., & Al-Mourabit, A. (2018). Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis. Marine Drugs, 16(5), 146. fdi:010072564. https://doi.org/10.3390/md16050146 Cite
Boufridi, A., Lachkar, D., Erpenbeck, D., Beniddir, M. A., Evanno, L., Petek, S., Debitus, C., & Poupon, E. (2017). Ilimaquinone and 5-epi-Ilimaquinone: Beyond a Simple Diastereomeric Ratio, Biosynthetic Considerations from NMR-Based Analysis. Australian Journal of Chemistry, 70(6), 743–750. https://doi.org/10.1071/CH16455 Cite
Bonneau, N., Chen, G., Lachkar, D., Boufridi, A., Gallard, J.-F., Retailleau, P., Petek, S., Debitus, C., Evanno, L., Beniddir, M. A., & Poupon, E. (2017). An Unprecedented Blue Chromophore Found in Nature using a “Chemistry First” and Molecular Networking Approach: Discovery of Dactylocyanines A-H. Chemistry-a European Journal, 23(58), 14454–14461. fdi:010071281. https://doi.org/10.1002/chem.201702336 Cite
Boufridi, A., Petek, S., Evanno, L., Beniddir, M. A., Debitus, C., Buisson, D., & Poupon, E. (2016). Biotransformations versus chemical modifications: new cytotoxic analogs of marine sesquiterpene ilimaquinone. Tetrahedron Letters, 57(44), 4922–4925. fdi:010068406. https://doi.org/10.1016/j.tetlet.2016.09.075 Cite
Mai T., Tintillier F., Lucasson A., Moriou C., Bonno E., Petek S., Magré K., Al-Mourabit A., Saulnier D., Debitus C. (2015). Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863, Lett. Appl. Microbiol., 61, 311-317. (Editor choice)
Laville R., Nguyen T.B., Moriou C., Petek S., Debitus C. and Al-Mourabit A. (2015). Marine natural occurring 2,5-diketopiperazines : isolation, synthesis and optical properties. Heterocycles, 90, 1351-1366.
Hall K. A., Sutcliffe P. R., Hooper J. N. A., Alencar A., Vacelet J., Pisera A., Petek S., Folcher E., Butscher J., Orempuller J., Maihota N., Debitus C. (2013). Affinities of sponges (Porifera) of the Marquesas and Society Islands, French Polynesia. Pacific Science, 67, 493-512.
Festa C., De Marino S., D’Auria M. V, Orazio Taglialatela-Scafati O., Deharo E., Petek S., Zampella A. (2013). New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands. Tetrahedron, 69, 3706-3713
Festa C., De Marino S., D’auria M. V., Deharo E., Gonzalez G., Deyssard C., Petek S., Bifulco G., Zampella A. (2012). Gracilioethers E-J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris. Tetrahedron, 68, 10157-10163.
Festa C., Lauro G., De Marino S., D’auria M. V., Monti M. C., Casapullo A., D’amore C., Renga B., Mencarelli A., Petek S., Bifulco G., Fiorucci S., Zampella A. (2012). Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ. Journal of Medicinal Chemistry, 55, 8303-8317.
De Marino S., Ummarino R., D’Auria M. V., Chini M. G., Bifulco G., D’amore C., Renga B., Mencarelli A., Petek S., Fiorucci S., Zampella A. (2012). 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity. Steroids, 77, 484-495.
Sorres J., Martin M. T., Petek S., Levaique H., Cresteil T., Ramos S., Thoison O., Debitus C., Al-Mourabit A. (2012). Pipestelides A-C: Cyclodepsipeptides from the Pacific Marine Sponge Pipestela candelabra. Journal of Natural Products, 75, 759-763.
Erpenbeck D., Hooper J., Bonnard I., Sutcliffe P., Chandra M., Perio P., Wolff C., Banaigs B., Wörheide G., Debitus C., Petek S. (2012). Evolution, radiation and chemotaxonomy of Lamellodysidea, a demosponge genus with anti-plasmodial metabolites. Marine Biology, 159, 1119-1127.
Mani L., Petek S., Valentin A., Chevalley S., Folcher E., Aalbersberg W., Debitus C. (2011). The in vivo anti-plasmodial activity of haliclonacyclamine A, an alkaloid from the marine sponge, Haliclona sp. Nat. Prod.Res., 25, 1923-1930.
Longeon A., Copp B. R., Quevrain E., Roué M., Kientz B., Cresteil T., Petek Sylvain, Debitus Cécile, Bourguet-Kondracki M. L. (2011). Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Mar. Drugs, 9, 879-888.
De Marino S., Sepe V., D’Auria M. V., Bifulco G., Renga B., Petek Sylvain, Fiorucci S., Zampella A. (2011). Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. Org. Biomol. Chem., 9, 4856-4862.
Festa, C.; De Marino, S.; D’Auria, M. V.; Bifulco, G.; Renga, B.; Fiorucci, S.; Petek, S.; Zampella, A. (2011). Solomonsterols A and B from Theonella swinhoei. The First Example of C-24 and C-23 Sulfated Sterols from a Marine Source Endowed with a PXR Agonistic Activity. J. Med. Chem., 54, 401-405.
Longeon, A., Copp, B. R., Roué, M., Dubois, J., Valentin, A., Petek, S., Debitus, C., ., Bourguet-Kondracki M. L. (2010). New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg. Med. Chem., 18, 6006-6011.
Tilvi Supriya, Moriou Celine, Martin Marie-Therese, Gallard Jean-Francois, Sorres Jonathan, Patel Kirti, Petek Sylvain, Debitus Cecile, Ermolenko Ludmila, Al-Mourabit Ali. (2010). Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha. J. Nat. Prod, 73 (4), 720-3.
De Marino S., Festa C., D’auria M. V., Bourguet-Kondracki M. L., Petek S., Debitus C., Andres R. M., Terencio M. C., Paya M., Zampella A. (2009). Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties. Tetrahedron, 65 (15), 2905-2909.
Zampella Angela, Sepe Valentina, Bellotta Filomena, Luciano Paolo, D’auria Maria Valeria, Cresteil Thierry, Debitus Cecile, Petek Sylvain, Poupat Christiane, Ahond Alain. (2009). Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp. Org. Biomol. Chem., 7 (19), 4037-44.
Appenzeller Jérôme, Mihci Ghezala, Martin Marie-Therese, Gallard Jean-François, Menou Jean-Louis, Boury-Esnault Nicole, Hooper John, Petek Sylvain, Chevalley Severine, Valentin Alexis, Zaparucha Anne, Al-Mourabit Ali, Debitus Cécile. (2008). Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana. J. Nat. Prod., 71 (8), 1451-1454.
Zampella Angela, Sepe Valentina, Luciano Paolo, Bellotta Filomena, Monti Maria Chiara, D’auria Maria Valeria, Jepsen Trine, Petek Sylvain, Adeline Marie-Therese, Laprevote Olivier, Aubertin Anne-Marie, Debitus Cécile, Poupat Christiane, Ahond Alain. (2008). Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp. J. Org. Chem., 73 (14), 5319-5327.
Grison Claude, Petek Sylvain, Coutrot Philippe. (2005). Investigation into the regioselective C-deuteriation of [alpha]-keto esters. Tetrahedron, 61 (30), 7193-7200.
Grison Claude, Petek Sylvain, Coutrot Philippe. (2005). Preparation of magnesium enolates of alpha-keto esters and synthetic applications. Synlett, (2), 331-333.
Grison Claude, Petek Sylvain, Finance Chantal, Coutrot Philippe. (2005). Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase. Carbohydrate Research, 340 (4), 529-537.
Xu Xingjue, Wang Jian, Grison Claude, Petek Sylvian, Coutrot Philippe, Birck Matthew R., Woodard Ronald W., Gatti Domenico L. (2003). Structure-based design of novel inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Drug Des Discov, 18 (2-3), 91-9.
