Studying how aquatic organisms will respond to future climate change has become one of the most active areas of research, as the answer to such a critical question will provide essential knowledge to mitigate the effects of global warming on biodiversity and thus on fisheries and aquaculture. The objective of CLIMCLAM is to address the fundamental and timely issue of the Manila clam's response to climate change. We propose here, through the international research project CLIMCLAM, to design and implement a unique, multi-level and transdisciplinary experimental research plan. The expected results will be pioneering in terms of science, conservation planning and food security management, completed by training of future generations to climate change biology, as well as in the evolution of hybrid human-clam collectives. Indeed, the outcome of our work will benefit from increased attention given the unprecedented and irreversible ecological transformation of all ecosystems due to climate change and multifactorial anthropogenic changes.