TY - JOUR TI - Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp. AU - Tintillier, Florent AU - Moriou, Celine AU - Petek, Sylvain AU - Fauchon, Marilyne AU - Hellio, Claire AU - Saulnier, Denis AU - Ekins, Merrick AU - Hooper, John N. A. AU - Al-Mourabit, Ali AU - Debitus, Cecile T2 - Marine Drugs AB - Four new brominated tyrosine metabolites, aplyzanzines C-F (1-4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time. DA - 2020/05// PY - 2020 DO - 10.3390/md18050272 DP - Web of Science VL - 18 IS - 5 SP - 272 J2 - Mar. Drugs LA - English UR - https://www.mdpi.com/1660-3397/18/5/272 AN - https://archimer.ifremer.fr/doc/00630/74200/ DB - fdi:010079097 KW - Pseudoceratina KW - ACL KW - IRD KW - Pseudoceratina KW - UBO KW - Verongiida KW - alkaloids KW - analogs KW - antifouling KW - aplysina KW - aplyzanzine KW - bromotyrosine KW - chemical ecology KW - chemistry KW - derivatives KW - gene-expression KW - marine sponges KW - panorama KW - quorum sensing inhibitory activity KW - sponge KW - system ER -