TY - JOUR TI - Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific oyster mortality syndrome AU - de Lorgeril, Julien AU - Petton, Bruno AU - Lucasson, Aude AU - Perez, Valerie AU - Stenger, Pierre-Louis AU - Degremont, Lionel AU - Montagnani, Caroline AU - Escoubas, Jean-Michel AU - Haffner, Philippe AU - Allienne, Jean-Francois AU - Leroy, Marc AU - Lagarde, Franck AU - Vidal-Dupiol, Jeremie AU - Gueguen, Yannick AU - Mitta, Guillaume T2 - Bmc Genomics AB - Background As a major threat to the oyster industry, Pacific Oyster Mortality Syndrome (POMS) is a polymicrobial disease affecting the main oyster species farmed across the world. POMS affects oyster juveniles and became panzootic this last decade, but POMS resistance in some oyster genotypes has emerged. While we know some genetic loci associated with resistance, the underlying mechanisms remained uncharacterized. So, we developed a comparative transcriptomic approach using basal gene expression profiles between different oyster biparental families with contrasted phenotypes when confronted to POMS (resistant or susceptible). Results We showed that POMS resistant oysters show differential expression of genes involved in stress responses, protein modifications, maintenance of DNA integrity and repair, and immune and antiviral pathways. We found similarities and clear differences among different molecular pathways in the different resistant families. These results suggest that the resistance process is polygenic and partially varies according to the oyster genotype. Conclusions We found differences in basal expression levels of genes related to TLR-NF kappa B, JAK-STAT and STING-RLR pathways. These differences could explain the best antiviral response, as well as the robustness of resistant oysters when confronted to POMS. As some of these genes represent valuable candidates for selective breeding, we propose future studies should further examine their function. DA - 2020/01/20/ PY - 2020 DO - 10.1186/s12864-020-6471-x DP - Web of Science VL - 21 IS - 1 SP - 63 J2 - BMC Genomics LA - English SN - 1471-2164 KW - ACL KW - Antiviral molecular pathways KW - Ifremer KW - Invertebrate immunity KW - OsHV-1 KW - Oyster disease KW - Pacific oyster KW - Resistance KW - infection KW - oshv-1 resistance KW - ostreid herpesvirus KW - panorama KW - responses KW - selection KW - summer mortality KW - survival KW - virus ER -