TY - JOUR TI - Low pH reduced survival of the oyster Crassostrea gigas exposed to the Ostreid herpesvirus 1 by altering the metabolic response of the host AU - Fuhrmann, Marine AU - Richard, Gaelle AU - Quere, Claudie AU - Petton, Bruno AU - Pernet, Fabrice T2 - Aquaculture AB - Environmental change in the marine realm has been accompanied by emerging diseases as new pathogens evolve to take advantage of hosts weakened by environmental stress. Here we investigated how an exposure to reduced seawater pH influenced the response of the oyster Crassostrea gigas to an infection by the Ostreid herpesvirus type I (OsHV-1). Oysters were acclimated at pH 8.1 or pH 7.8 and then exposed to OsHV-1. Their survival was monitored and oyster tissues were sampled for biochemical analyses. The survival of oysters exposed to OsHV-1 at pH 7.8 was lower (33.5%) than that of their counterparts at pH 8.1 (44.8%) whereas levels of OsHV-1 DNA were similar. Energetic reserves, fatty acid composition and prostaglandin levels in oyster did not vary consistently with pH, infection or their interactions. However, there was a reduction in the activities of superoxide dismutase (SOD) and nitric oxide synthase (iNOS) in oysters at low pH, which is associated with the observed difference in survival. DA - 2019/03/30/ PY - 2019 DO - 10.1016/j.aquaculture.2018.12.052 DP - Web of Science VL - 503 SP - 167 EP - 174 J2 - Aquaculture LA - English SN - 0044-8486 UR - https://archimer.ifremer.fr/doc/00472/58334/ DB - http://www.sciencedirect.com/science/article/pii/S0044848618321860 KW - ACL KW - Acidification KW - Bivalve KW - Disease KW - Environment KW - GIGASSAT_ANR-12-AGRO-0001 KW - Ifremer KW - Metabolism KW - Mortality risk KW - UBO KW - climate-change KW - immune-responses KW - impacts KW - ocean acidification KW - oxidative stress KW - pacific oyster KW - panorama KW - pathogen interactions KW - seawater acidification KW - temperature adaptation KW - vibrio-tapetis ER -